RNA viruses in trypanosomatid parasites: a historical overview

Grybchuk, Danyil; Kostygov, Alexei Y.; Macedo, Diego H.; d’Avila-Levy, Claudia M.; Yurchenko, Vyacheslav

doi:10.1590/0074-02760170487

Cited by 27 publications

(21 citation statements)

References 85 publications

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“…It was estimated that viruses lyse about 20% of oceanic protists daily and, thus, play a major role in regulating the Earth's biogeochemical cycle [ 427 ]. Euglenozoa are no exception to this rule, although viral diversity was thoroughly investigated only in kinetoplastids [ 428 ]. The reason for such discrepancy is obvious—this is by far the best-studied group, which includes several parasites of medical or economic importance [ 10 ].…”

Section: Viruses In Euglenozoamentioning

confidence: 99%

Euglenozoa: taxonomy, diversity and ecology, symbioses and viruses

et al. 2021

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Euglenozoa is a species-rich group of protists, which have extremely diverse lifestyles and a range of features that distinguish them from other eukaryotes. They are composed of free-living and parasitic kinetoplastids, mostly free-living diplonemids, heterotrophic and photosynthetic euglenids, as well as deep-sea symbiontids. Although they form a well-supported monophyletic group, these morphologically rather distinct groups are almost never treated together in a comparative manner, as attempted here. We present an updated taxonomy, complemented by photos of representative species, with notes on diversity, distribution and biology of euglenozoans. For kinetoplastids, we propose a significantly modified taxonomy that reflects the latest findings. Finally, we summarize what is known about viruses infecting euglenozoans, as well as their relationships with ecto- and endosymbiotic bacteria.

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Section: Viruses In Euglenozoamentioning

confidence: 99%

Euglenozoa: taxonomy, diversity and ecology, symbioses and viruses

et al. 2021

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“…Different viruses can also infect trypanosomatids and play an important role in their biology (Ives et al , 2011; Grybchuk et al , 2018 a ). We refer readers to several recent reviews discussing this topic (Lukeš et al , 2018; Grybchuk et al , 2018 b ).…”

Section: Endosymbionts Of Trypanosomatidsmentioning

confidence: 99%

Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution

et al. 2018

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Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number of diseases in humans, domestic animals and plants. Their monoxenous relatives are restricted to insects. Because of the high biological diversity, adaptability to dramatically different environmental conditions, and omnipresence, these protists have major impact on all biotic communities that still needs to be fully elucidated. In addition, as these organisms represent a highly divergent evolutionary lineage, they are strikingly different from the common 'model system' eukaryotes, such as some mammals, plants or fungi. A number of excellent reviews, published over the past decade, were dedicated to specialized topics from the areas of trypanosomatid molecular and cell biology, biochemistry, host-parasite relationships or other aspects of these fascinating organisms. However, there is a need for a more comprehensive review that summarizing recent advances in the studies of trypanosomatids in the last 30 years, a task, which we tried to accomplish with the current paper.

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“…This, in turn, facilitates the parasites’ dissemination to the secondary site (nasal mucosa), manifesting itself as a muco-cutaneous leishmaniasis (MCL) [15,16]. These crucial findings spurred the research on prevalence and diversity of Leishmania viruses [17], as well as viruses infecting other trypanosomatids [18,19]. The primary focus of this research was LRV1 in Leishmania ( Viannia ) spp.…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterization of Leishmania RNA virus 2 in Leishmania major from Uzbekistan

Kleschenko

Grybchuk

Matveeva

et al. 2019

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Here we report sequence and phylogenetic analysis of two new isolates of Leishmania RNA virus 2 (LRV2) found in Leishmania major isolated from human patients with cutaneous leishmaniasis in south Uzbekistan. These new virus-infected flagellates were isolated in the same region of Uzbekistan and the viral sequences differed by only nineteen SNPs, all except one being silent mutations. Therefore, we concluded that they belong to a single LRV2 species. New viruses are closely related to the LRV2-Lmj-ASKH documented in Turkmenistan in 1995, which is congruent with their shared host (L. major) and common geographical origin.

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RNA viruses in trypanosomatid parasites: a historical overview

Cited by 27 publications

References 85 publications

Euglenozoa: taxonomy, diversity and ecology, symbioses and viruses

Euglenozoa: taxonomy, diversity and ecology, symbioses and viruses

Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution

Molecular Characterization of Leishmania RNA virus 2 in Leishmania major from Uzbekistan

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