2017
DOI: 10.1016/j.neurobiolaging.2017.04.005
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RNA sequencing reveals pronounced changes in the noncoding transcriptome of aging synaptosomes

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Cited by 20 publications
(25 citation statements)
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“…Indeed, the synaptic transcriptome can be modulated by circadian cycles, alcohol exposure, aging and in schizophrenia. 64,[66][67][68] Interestingly, comparison of synaptoneurosomes to homogenized forebrain revealed that 70% of all synapse localized transcripts were altered at least 2-fold with daily circadian cycles. Ninety-three percent of oscillating transcripts showed this behavior only in synaptoneurosomes.…”
Section: Local Translation In Axonsmentioning
confidence: 99%
See 1 more Smart Citation
“…Indeed, the synaptic transcriptome can be modulated by circadian cycles, alcohol exposure, aging and in schizophrenia. 64,[66][67][68] Interestingly, comparison of synaptoneurosomes to homogenized forebrain revealed that 70% of all synapse localized transcripts were altered at least 2-fold with daily circadian cycles. Ninety-three percent of oscillating transcripts showed this behavior only in synaptoneurosomes.…”
Section: Local Translation In Axonsmentioning
confidence: 99%
“…However, the synaptic transcriptome is not static. Indeed, the synaptic transcriptome can be modulated by circadian cycles, alcohol exposure, aging and in schizophrenia 64,66‐68 . Interestingly, comparison of synaptoneurosomes to homogenized forebrain revealed that 70% of all synapse localized transcripts were altered at least 2‐fold with daily circadian cycles.…”
Section: Rna Localization and Local Translation In Neuronsmentioning
confidence: 99%
“…The transcriptomes of mammalian brains show widespread changes during aging [ 6 ]. In addition to changes in transcript expression and the usage of alternative isoforms and promoters of protein-coding genes [ 114 , 115 , 116 , 117 ], quantitative and qualitative changes in the non-coding transcriptome also occur with age [ 115 , 118 ]. Epigenetic alterations inherent to the aging process, such as altered patterns of histone post-translational modifications and DNA methylation, have been considered as the basis for an aged transcriptome [ 4 , 8 ].…”
Section: Lncrna-mediated Processes In the Pathogenesis Of Neurodegmentioning
confidence: 99%
“…We recently determined local transcriptome changes in synaptosome fractions from young and aging mice using RNA sequencing technique [ 3 ]. This study provides, for the first time, insights into age-related changes in gene expression profiles that encode proteins and non-coding transcripts with unprecedented resolution.…”
mentioning
confidence: 99%
“…Our comparative analysis revealed that the majority of the differentially expressed genes, involved in the aging process within the synapses, are novel and their RNA products do not have protein coding capacity. In addition, a significant proportion of these unannotated genes was identified as putative lncRNAs, an RNA species previously identified as important regulatory molecules in the maintenance of neuronal functionality [ 3 ].…”
mentioning
confidence: 99%