RNA Polymer Translocation with Single-Walled Carbon Nanotubes

Lu, Qi; Moore, Jessica M.; Huang, George T.‐J.; Mount, Andrew S.; Rao, Apparao M.; Larcom, Lyndon L.; Ke, Pu Chun

doi:10.1021/nl048326j

Cited by 298 publications

(204 citation statements)

References 22 publications

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“…Because of their unique physical and chemical properties, nano-materials have great potential use in agriculture, computer, medicine, military and many other areas. Simultaneously, it has been recognized that because of their ultrafine particle size, nano-materials can enter cells or even cross the blood-brain carrier [1][2][3] and cause harm to organisms. Much research has been done to investigate the toxicity of nano-materials on organisms [4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Aqueous stability of oxidized carbon nanotubes and the precipitation by salts

Peng

Jia

Gong

et al. 2009

Journal of Hazardous Materials

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Section: Introductionmentioning

confidence: 99%

Aqueous stability of oxidized carbon nanotubes and the precipitation by salts

Peng

Jia

Gong

et al. 2009

Journal of Hazardous Materials

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“…Pioneering in vitro studies have shown that SWNTs and SWNHs can be used to deliver therapeutic drugs and diagnostic molecules into cells (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Carbonaceous tubules absorb light in the near-infrared region, and can cause cell death by a localized photothermal or photohyperthermia (PHT) effect (14).…”

mentioning

confidence: 99%

Fabrication of ZnPc/protein nanohorns for double photodynamic and hyperthermic cancer phototherapy

Zhang

Murakami

Ajima

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

252

186

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Multifunctionalization of carbon nanotubules is easily achieved by attaching functional molecules that provide specific advantages for microscopic applications. We fabricated a double photodynamic therapy (PDT) and photohyperthermia (PHT) cancer phototherapy system that uses a single laser. Zinc phthalocyanine (ZnPc) was loaded onto single-wall carbon nanohorns with holes opened (SWNHox), and the protein bovine serum albumin (BSA) was attached to the carboxyl groups of SWNHox. In this system, ZnPc was the PDT agent, SWNHox was the PHT agent, and BSA enhanced biocompatibility. The double phototherapy effect was confirmed in vitro and in vivo. When ZnPc-SWNHox-BSA was injected into tumors that were subcutaneously transplanted into mice, the tumors almost disappeared upon 670-nm laser irradiation. In contrast, the tumors continued to grow when only ZnPc or SWNHox-BSA was injected. We conclude that carbon nanotubules may be a valuable new tool for use in cancer phototherapy.carbon nanotubules ͉ drug carrier ͉ drug delivery system ͉ nanoparticle ͉ photohyperthermia

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“…46,49,50 Among nanomaterials, CNTs are known as effective transporters of biological macromolecules and drugs to target cells and tissues. 4,6,[17][18][19][20][21][22][23][24] However, this type of medical application implies intravenous administration and translocation into to the blood circulation. Therefore, this study investigated whether MWCNTs produce cytotoxic and genotoxic effects in healthy HPBLs.…”

Section: Discussionmentioning

confidence: 99%

“…16 The CNTs could be adsorbed or conjugated with various therapeutic molecules such as peptides, proteins, DNA, RNA, and drugs. 4,6,7,[17][18][19][20][21][22][23][24] The CNT-bioactive molecule complex has been proven to be an excellent vehicle for drug delivery by penetrating into cells and keeping the drug from being metabolized during transport. [25][26][27][28] However, these medicinal findings are in an experimental stage and are still not applied to human medicine.…”

Section: Introductionmentioning

confidence: 99%

Multiwall Carbon Nanotube-Induced DNA Damage and Cytotoxicity in Male Human Peripheral Blood Lymphocytes

Kim

Song

2015

Int J Toxicol

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Carbon nanotubes (CNTs) have been introduced recently as a novel carrier system for both small and large therapeutic molecules. Biotin-functionalized single-wall CNTs have been conjugated with the anticancer agent taxoid using a cleavable linker, and multiwall carbon nanotubes (MWCNTs) conjugated with iron nanoparticles have been efficiently loaded with doxorubicin. 1,2The MWCNTs are effective transporters for biological macromolecules and drugs to target cells and tissues, thereby attracting the attention of the biomedical industry.3-7 Administrating MWCNTs for medical application invariably involves intravenous administration and ultimate contact with human peripheral blood lymphocytes (HPBLs), yet toxicological studies on the effect of MWCNTs on HPBLs are lacking. Accordingly, this study evaluated the cytotoxic and genotoxic effects of MWCNTs on healthy male HPBLs. Healthy male HPBLs were treated with MWCNTs at 3 different concentrations (12.5, 25, and 50 mg/mL) for 48 hours. Under these conditions, the MWCNTs induced significant cell growth retardation, DNA damage, and cytotoxicity. The MWCNT-treated HPBLs also exhibited an increased intracellular reactive oxygen species level during the experimental period, which leads to cell damage and death, proliferation inhibition, DNA damage, and an inflammatory response.

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RNA Polymer Translocation with Single-Walled Carbon Nanotubes

Cited by 298 publications

References 22 publications

Aqueous stability of oxidized carbon nanotubes and the precipitation by salts

Aqueous stability of oxidized carbon nanotubes and the precipitation by salts

Fabrication of ZnPc/protein nanohorns for double photodynamic and hyperthermic cancer phototherapy

Multiwall Carbon Nanotube-Induced DNA Damage and Cytotoxicity in Male Human Peripheral Blood Lymphocytes

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