RNA methylation in mammalian development and cancer

Song, Peizhe; Tayier, Subiding; Cai, Zhihe; Jia, Guifang

doi:10.1007/s10565-021-09627-8

Cited by 77 publications

(69 citation statements)

References 166 publications

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“…Outside of hematopoiesis, m 6 A has been found to be a critical regulator in stem cell fate, neuronal development, and skin development. The role of m 6 A in development and stem cell biology is reviewed extensively elsewhere ( Frye et al, 2018 ; Malla et al, 2019 ; Rosselló-Tortella et al, 2020 ; Vasic et al, 2020 ; Song et al, 2021 ). Here we will summarize the role of m 6 A in differentiation in several contexts.…”

Section: The Role Of M 6 a In Diverse Cellular Fun...mentioning

confidence: 99%

Roles of RNA Modifications in Diverse Cellular Functions

Wilkinson

Cui

2022

Front. Cell Dev. Biol.

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Chemical modifications of RNA molecules regulate both RNA metabolism and fate. The deposition and function of these modifications are mediated by the actions of writer, reader, and eraser proteins. At the cellular level, RNA modifications regulate several cellular processes including cell death, proliferation, senescence, differentiation, migration, metabolism, autophagy, the DNA damage response, and liquid-liquid phase separation. Emerging evidence demonstrates that RNA modifications play active roles in the physiology and etiology of multiple diseases due to their pervasive roles in cellular functions. Here, we will summarize recent advances in the regulatory and functional role of RNA modifications in these cellular functions, emphasizing the context-specific roles of RNA modifications in mammalian systems. As m6A is the best studied RNA modification in biological processes, this review will summarize the emerging advances on the diverse roles of m6A in cellular functions. In addition, we will also provide an overview for the cellular functions of other RNA modifications, including m5C and m1A. Furthermore, we will also discuss the roles of RNA modifications within the context of disease etiologies and highlight recent advances in the development of therapeutics that target RNA modifications. Elucidating these context-specific functions will increase our understanding of how these modifications become dysregulated during disease pathogenesis and may provide new opportunities for improving disease prevention and therapy by targeting these pathways.

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Section: The Role Of M 6 a In Diverse Cellular Fun...mentioning

confidence: 99%

Roles of RNA Modifications in Diverse Cellular Functions

Wilkinson

Cui

2022

Front. Cell Dev. Biol.

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“…Many studies have shown that the high expression of almost all m5C regulators is significantly related to the shorter overall survival period of HCC patients except for NSUN7, suggesting that the dysfunction of m5C regulators has a strong impact on HCC progression (He et al, 2021). Since then, a study used clinical information from the TCGA database to assess m5C regulator alterations and the survival rate in patients and found that the p-value of the NSUN5 and ALYREF genes in HCC is less than 0.05, as well as the significant difference in the NSUN6 gene, which provides an important basis for exploring m5C regulators as potential therapeutic targets for HCC (Song et al, 2021). Moreover, gene set enrichment analysis (GSEA) showed that the high expression of NSUN4 and ALYREF mainly affects the m5C methylation/demethylation process, cell cycle regulation and mitosis, respectively, which is closely related to the prognosis of HCC (He et al, 2020a).…”

Section: Rna 5-methylcytosine Epigenetic Modification In Hepatocellular Carcinomamentioning

confidence: 99%

Advances in RNA Epigenetic Modifications in Hepatocellular Carcinoma and Potential Targeted Intervention Strategies

Zhu

Cai

et al. 2021

Front. Cell Dev. Biol.

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The current interventions for hepatocellular carcinoma (HCC) are not satisfactory, and more precise targets and promising strategies need to be explored. Recent research has demonstrated the non-negligible roles of RNA epigenetic modifications such as N6-methyladenosine (m6A) and 5-methylcytosine (m5C) in various cancers, including HCC. However, the specific targeting mechanisms are not well elucidated. In this review, we focus on the occurrence and detailed physiopathological roles of multiple RNA modifications on diverse RNAs closely related to the HCC process. In particular, we highlight fresh insights into the impact mechanisms of these posttranscriptional modifications on the whole progression of HCC. Furthermore, we analyzed the possibilities and significance of these modifications and regulators as potential therapeutic targets in HCC treatment, which provides the foundation for exploring targeted intervention strategies. This review will propel the identification of promising therapeutic targets and novel strategies that can be translated into clinical applications for HCC treatment.

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“… 2 , 3 RNA methylation is one of the predominant forms of epigenetic modification, accounting for >60% of RNA modifications. 4 The common sites of RNA methylation mainly include N 6 -methyladenosine (m 6 A), 5-methylcytosine (m 5 C), N 1 -methyladenosine (m 1 A) and 7-methylguanosine (m 7 G). As the most prevalent type among these methylations, m 6 A, which describes a methylation at the N 6 position of adenosine and enriched in the consensus sequence RRACH (R: A or G; A: m 6 A; and H: A, C, or U), has become a hotspot in the research community.…”

Section: Introductionmentioning

confidence: 99%