Advances in RNA Epigenetic Modifications in Hepatocellular Carcinoma and Potential Targeted Intervention Strategies

Zhu, Liran; Ni, Wei‐Jian; Cai, Ming; Dai, Wentao; Zhou, Hong

doi:10.3389/fcell.2021.777007

Cited by 9 publications

(5 citation statements)

References 130 publications

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“…The current interventions for HCC are not satisfactory, and more precise prognostic indicator and promising strategies need to be explored. Recent studies point out that RNA modifiers play vital roles in HCC cell proliferation, exacerbation, and metastasis ( Zhu et al, 2021 ). However, these studies are mainly limited to several RNA modification regulators.…”

Section: Discussionmentioning

confidence: 99%

Analysis of eight types of RNA modification regulators and their correlation with the prognosis in hepatocellular carcinoma

2023

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RNA modification plays important role in the occurrence and development of hepatocellular carcinoma. The best characterized RNA modification is m6A, while other kinds of RNA modifications have not been fully investigated in hepatocellular carcinoma (HCC). In the current study, we investigated the roles of one hundred RNA modification regulators belonging to eight different types of cancer-related RNA modifications in HCC. Expression analysis revealed that nearly 90% RNA regulators exhibited significantly higher expression in tumors than normal tissues. By consensus clustering, we identified two clusters with distinct biological characteristics, immune microenvironment, and prognostic pattern. An RNA modification score (RMScore) was constructed and stratified patients into high- and low-risk group, which showed significantly different prognosis. Moreover, a nomogram including clinicopathologic features and the RMScore could well predict the survival in HCC patients. This study indicated the important role of eight types of RNA modification in HCC and develop a RMScore, which will be a new method to forecast the prognosis of HCC patients.

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Section: Discussionmentioning

confidence: 99%

Analysis of eight types of RNA modification regulators and their correlation with the prognosis in hepatocellular carcinoma

2023

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“…It plays an important role in cancerous cells' growth and proliferation, invasion, and malignant phenotype transformation. Promisingly, METTL1 is Frontiers in Genetics frontiersin.org a biomarker for the diagnosis and prognosis of HCC (Zhu L. R. et al, 2021). Despite being one of the most indispensable m 7 G-related genes, the overall relevance of METTL1 in cancer remains mostly unclear.…”

Section: Figurementioning

confidence: 99%

The pattern of expression and prognostic value of key regulators for m7G RNA methylation in hepatocellular carcinoma

et al. 2022

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N7-methylguanosine (m7G) modification on internal RNA positions plays a vital role in several biological processes. Recent research shows m7G modification is associated with multiple cancers. However, in hepatocellular carcinoma (HCC), its implications remain to be determined. In this place, we need to interrogate the mRNA patterns for 29 key regulators of m7G RNA modification and assess their prognostic value in HCC. Initial, the details from The Cancer Genome Atlas (TCGA) database concerning transcribed gene data and clinical information of HCC patients were inspected systematically. Second, according to the mRNA profiles of 29 m7G RNA methylation regulators, two clusters (named 1 and 2, respectively) were identified by consensus clustering. Furthermore, robust risk signature for seven m7G RNA modification regulators was constructed. Last, we used the Gene Expression Omnibus (GEO) dataset to validate the prognostic associations of the seven-gene risk signature. We figured out that 24/29 key regulators of m7G RNA modification varied remarkably in their grades of expression between the HCC and the adjacent tumor control tissues. Cluster one compared with cluster two had a substandard prognosis and was also positively correlated with T classification (T), pathological stage, and vital status (fustat) significantly. Consensus clustering results suggested the expression pattern of m7G RNA modification regulators was correlated with the malignancy of HCC strongly. In addition, cluster one was extensively enriched in metabolic-related pathways. Seven optimal genes (METTL1, WDR4, NSUN2, EIF4E, EIF4E2, NCBP1, and NCBP2) were selected to establish the risk model for HCC. Indicating by further analyses and validation, the prognostic model has fine anticipating command and this probability signature might be a self supporting presage factor for HCC. Finally, a new prognostic nomogram based on age, gender, pathological stage, histological grade, and prospects were established to forecast the prognosis of HCC patients accurately. In essence, we detected association of HCC severity and expression levels of m7G RNA modification regulators, and developed a risk score model for predicting prognosis of HCC patients’ progression.

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“…Epidemiological studies have indicated that liver diseases constitute an important part of global morbidity and mortality and have become a huge economic burden and an urgent public health crisis ( 2 , 3 ). However, due to the lack of understanding of their pathogenesis, late diagnosis and rapid progression, the clinical therapeutic strategies for liver diseases are still insufficient, which directly leads to unsatisfactory treatment effects ( 4 ). Therefore, the clinical treatment and management of liver diseases remains a considerable challenge, and there is an urgent need to deeply explore the mechanism and develop promising therapeutic drugs and strategies on this basis.…”

Section: Introductionmentioning

confidence: 99%

Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy

Zhu

Zheng

et al. 2023

Front. Immunol.

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The gut microbiota not only constitutes intestinal microenvironment homeostasis and human health but also exerts indispensable roles in the occurrence and progression of multiple liver diseases, including alcohol-related liver disease, nonalcoholic fatty liver disease, autoimmune liver disease and liver cancer. Given the therapeutic status of these diseases, their prevention and early therapy are crucial, and the detailed mechanism of gut microbiota in liver disease urgently needs to be explored. Meanwhile, multiple studies have shown that various traditional Chinese medicines, such as Si Miao Formula, Jiangzhi Granules, Liushen Capsules, Chaihu-Shugan Power, Cassiae Semen and Gynostemma, as well as some natural products, including Costunolide, Coprinus comatus polysaccharide, Antarctic krill oil, Oridonin and Berberine, can repair liver injury, improve fatty liver, regulate liver immunity, and even inhibit liver cancer through multiple targets, links, and pathways. Intriguingly, the aforementioned effects demonstrated by these traditional Chinese medicines and natural products have been shown to be closely related to the gut microbiota, directly driving the strategy of traditional Chinese medicines and natural products to regulate the gut microbiota as one of the breakthroughs in the treatment of liver diseases. Based on this, this review comprehensively summarizes and discusses the characteristics, functions and potential mechanisms of these medicines targeting gut microbiota during liver disease treatment. Research on the potential effects on gut microbiota and the regulatory mechanisms of traditional Chinese medicine and natural products provides novel insights and significant references for developing liver disease treatment strategies. In parallel, such explorations will enhance the comprehension of traditional Chinese medicine and natural products modulating gut microbiota during disease treatment, thus facilitating their clinical investigation and application.

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Advances in RNA Epigenetic Modifications in Hepatocellular Carcinoma and Potential Targeted Intervention Strategies

Cited by 9 publications

References 130 publications

Analysis of eight types of RNA modification regulators and their correlation with the prognosis in hepatocellular carcinoma

Analysis of eight types of RNA modification regulators and their correlation with the prognosis in hepatocellular carcinoma

The pattern of expression and prognostic value of key regulators for m7G RNA methylation in hepatocellular carcinoma

Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy

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