RNA G-quadruplex regulates microRNA-26a biogenesis and function

Li, Geng; Du, Wenya; Xu, Haixia; Sun, Qiu; Tang, Dongmei; Zou, Sailan; Zhang, Yu; Ma, Ming; Zhang, Guixiang; Du, Xiao; Ju, Shenggen; Cheng, Wei; Tian, Yan; Fu, Xianghui

doi:10.1016/j.jhep.2020.02.032

Cited by 42 publications

(47 citation statements)

References 57 publications

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“…Among the cellular processes hijacked by altered RG4 regulation, there are proliferation and survival, cell cycle, apoptosis, differentiation, invasion and migration, antigen presentation, and immunoglobulin class switch recombination (Figure 1). In addition to cancer, microbial pathogenesis, and neurodegeneration, recent studies point to a possible implication of RG4 dysregulation in congenital heart disease [83] and obesity [84].…”

Section: Rg4 Misregulation In Disease: Focus On Immune Evasionmentioning

confidence: 99%

G-Quadruplexes in RNA Biology: Recent Advances and Future Directions

Dumas

Herviou

Dassi

et al. 2021

Trends in Biochemical Sciences

121

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Section: Rg4 Misregulation In Disease: Focus On Immune Evasionmentioning

confidence: 99%

G-Quadruplexes in RNA Biology: Recent Advances and Future Directions

Dumas

Herviou

Dassi

et al. 2021

Trends in Biochemical Sciences

121

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“…In the case of pre-miR-26a-1, G4 unwinding achieved by the RNA helicase DHX36 favors the physiological accumulation of mature miR-26a, and impairing DHX36 activity leads to low miR-26a abundance and obesity [220]. It has also been reported that G4 structures are retained in a number of biologically relevant human microRNAs in their mature form, suggesting that G4 formation could impact microRNA-directed post-transcriptional regulation of gene expression by affecting microRNA-target mRNA interactions [221].…”

Section: Epigenetic Roles Of G4 Structures Formed In Coding and Noncoding Rna Transcriptsmentioning

confidence: 99%

Epigenetic Modulation of Chromatin States and Gene Expression by G-Quadruplex Structures

Reina

Cavalieri

2020

IJMS

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G-quadruplexes are four-stranded helical nucleic acid structures formed by guanine-rich sequences. A considerable number of studies have revealed that these noncanonical structural motifs are widespread throughout the genome and transcriptome of numerous organisms, including humans. In particular, G-quadruplexes occupy strategic locations in genomic DNA and both coding and noncoding RNA molecules, being involved in many essential cellular and organismal functions. In this review, we first outline the fundamental structural features of G-quadruplexes and then focus on the concept that these DNA and RNA structures convey a distinctive layer of epigenetic information that is critical for the complex regulation, either positive or negative, of biological activities in different contexts. In this framework, we summarize and discuss the proposed mechanisms underlying the functions of G-quadruplexes and their interacting factors. Furthermore, we give special emphasis to the interplay between G-quadruplex formation/disruption and other epigenetic marks, including biochemical modifications of DNA bases and histones, nucleosome positioning, and three-dimensional organization of chromatin. Finally, epigenetic roles of RNA G-quadruplexes in post-transcriptional regulation of gene expression are also discussed. Undoubtedly, the issues addressed in this review take on particular importance in the field of comparative epigenetics, as well as in translational research.

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“…This G4 impairs the pre-miRNA-26a maturation and decreases its expression. The structure is formed by four G-stretches, two guanines in the first three G-tracts and three guanines in the last G-tract, in line with a non-canonical G4 with two G-tetrads [ 83 ]. An onco-suppressive role was also attributed to miRNA-149 controlling cell migration and apoptosis with a low expression in cancer cells [ 153 , 154 ].…”

Section: Relevant Quadruplex Structures Involved In Cancermentioning

confidence: 99%

An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer

Sánchez-Martín

López-Pujante

Soriano

et al. 2020

IJMS

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Non-canonical, four-stranded nucleic acids secondary structures are present within regulatory regions in the human genome and transcriptome. To date, these quadruplex structures include both DNA and RNA G-quadruplexes, formed in guanine-rich sequences, and i-Motifs, found in cytosine-rich sequences, as their counterparts. Quadruplexes have been extensively associated with cancer, playing an important role in telomere maintenance and control of genetic expression of several oncogenes and tumor suppressors. Therefore, quadruplex structures are considered attractive molecular targets for cancer therapeutics with novel mechanisms of action. In this review, we provide a general overview about recent research on the implications of quadruplex structures in cancer, firstly gathering together DNA G-quadruplexes, RNA G-quadruplexes as well as DNA i-Motifs.

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RNA G-quadruplex regulates microRNA-26a biogenesis and function

Cited by 42 publications

References 57 publications

G-Quadruplexes in RNA Biology: Recent Advances and Future Directions

G-Quadruplexes in RNA Biology: Recent Advances and Future Directions

Epigenetic Modulation of Chromatin States and Gene Expression by G-Quadruplex Structures

An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer

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