RNA-binding proteins: Underestimated contributors in tumorigenesis

Zhao, Yuchong; Mir, Cristina; García-Mayea, Yoelsis; Paciucci, Rosanna; Kondoh, Eiji; Lleonart, Matilde E.

doi:10.1016/j.semcancer.2022.01.010

Cited by 15 publications

(16 citation statements)

References 146 publications

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“…RBPs are involved in alternative RNA splicing, polyadenylation, RNA transport, RNA stability, the rate of translation, and finally the levels of protein produced. In addition, RNAs are bound by a variety of RBPs, which coordinate with each other to post-transcriptionally control the processes of RNA ( Figure 2 ) [ 26 , 27 ].…”

Section: Post-transcriptional Control Of Adipogenesismentioning

confidence: 99%

RNA-Binding Proteins in the Regulation of Adipogenesis and Adipose Function

Zhang

et al. 2022

Cells

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The obesity epidemic represents a critical public health issue worldwide, as it is a vital risk factor for many diseases, including type 2 diabetes (T2D) and cardiovascular disease. Obesity is a complex disease involving excessive fat accumulation. Proper adipose tissue accumulation and function are highly transcriptional and regulated by many genes. Recent studies have discovered that post-transcriptional regulation, mainly mediated by RNA-binding proteins (RBPs), also plays a crucial role. In the lifetime of RNA, it is bound by various RBPs that determine every step of RNA metabolism, from RNA processing to alternative splicing, nucleus export, rate of translation, and finally decay. In humans, it is predicted that RBPs account for more than 10% of proteins based on the presence of RNA-binding domains. However, only very few RBPs have been studied in adipose tissue. The primary aim of this paper is to provide an overview of RBPs in adipogenesis and adipose function. Specifically, the following best-characterized RBPs will be discussed, including HuR, PSPC1, Sam68, RBM4, Ybx1, Ybx2, IGF2BP2, and KSRP. Characterization of these proteins will increase our understanding of the regulatory mechanisms of RBPs in adipogenesis and provide clues for the etiology and pathology of adipose-tissue-related diseases.

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Section: Post-transcriptional Control Of Adipogenesismentioning

confidence: 99%

RNA-Binding Proteins in the Regulation of Adipogenesis and Adipose Function

Zhang

et al. 2022

Cells

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“…Each transcript of mature mRNA contains a polyadenylate tail that determines its stability. RBPs involved in polyadenylation include U1 small nuclear ribonucleic protein (U1 snRNP), cleavage and polyadenylation-specific factor 1 (CPSF1), embryonic lethal abnormal vision (ELAV) L1/human antigen R (HuR), and poly(A) RNA-binding protein (examples include the cytoplasmic polyadenylate element-binding protein family, CPEB1–4), and the ZFP36 ring finger protein (ZFP36/TTP) [ 35 ]. CPEB family proteins recruit the translational inhibitory factors or cytoplasmic polyadenylation factors and regulate the length of the poly(A) tail.…”

Section: Regulations Of Rna Metabolism By Rbpsmentioning

confidence: 99%

Pathogenic Roles of RNA-Binding Proteins in Sarcomas

Kawachi

et al. 2022

Cancers

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RNA-binding proteins (RBPs) are proteins that physically and functionally bind to RNA to regulate the RNA metabolism such as alternative splicing, polyadenylation, transport, maintenance of stability, localization, and translation. There is accumulating evidence that dysregulated RBPs play an essential role in the pathogenesis of malignant tumors including a variety of types of sarcomas. On the other hand, prognosis of patients with sarcoma, especially with sarcoma in advanced stages, is very poor, and almost no effective standard treatment has been established for most of types of sarcomas so far, highlighting the urgent need for identifying novel therapeutic targets based on the deep understanding of pathogenesis. Therefore, defining the network of interactions between RBPs and disease-related RNA targets will contribute to a better understanding of sarcomagenesis and identification of a novel therapeutic target for sarcomas.

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“…The dynamic interaction between RBPs and their RNA targets is mediated with RNA‐binding domains (RBDs) residing exclusively in RBPs 13,17,18 . RBDs are deeply conserved across various divergent species and implicated in binding targets and preferences of RBPs 11 . Consequently, the diversity of RBDs complicates the identification and classification of RBPs.…”

Section: Introductionmentioning

confidence: 99%

Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis

Li,

Gao

et al. 2023

Orthopaedic Surgery

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The etiology of intervertebral disc degeneration (IDD) and osteoarthritis (OA) is complex and multifactorial. Both predisposing genes and environmental factors are involved in the pathogenesis of IDD and OA. Moreover, epigenetic modifications affect the development of IDD and OA. Dysregulated phenotypes of nucleus pulposus (NP) cells and OA chondrocytes, including apoptosis, extracellular matrix disruption, inflammation, and angiogenesis, are involved at all developmental stages of IDD and OA. RNA binding proteins (RBPs) have recently been recognized as essential post‐transcriptional regulators of gene expression. RBPs are implicated in many cellular processes, such as proliferation, differentiation, and apoptosis. Recently, several RBPs have been reported to be associated with the pathogenesis of IDD and OA. This review briefly summarizes the current knowledge on the RNA‐regulatory networks controlled by RBPs and their potential roles in the pathogenesis of IDD and OA. These initial findings support the idea that specific modulation of RBPs represents a promising approach for managing IDD and OA.

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RNA-binding proteins: Underestimated contributors in tumorigenesis

Cited by 15 publications

References 146 publications

RNA-Binding Proteins in the Regulation of Adipogenesis and Adipose Function

RNA-Binding Proteins in the Regulation of Adipogenesis and Adipose Function

Pathogenic Roles of RNA-Binding Proteins in Sarcomas

Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis

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