In this work, a systematic analysis of the transmission line models used for high-frequency global interconnection lines is presented. As part of this analysis, two model implementations are carried out using: i) the technology parameters provided by the manufacturer, and ii) the scattering (S ij ) parameters associated with a transmission line. In order to serve as test vehicles, a chain of inverters and several ring oscillators with lines of width w i =2 µm and length l i =1.0 to 3.0 mm were implemented using an Austriamiscrosystems 0.35 µm process technology and a power supply of 3.3 V. The simulation results using the equivalent model obtained from S-parameters show the lowest average error when they are compared with post layout simulations. In addition, the obtained results show that the total delay in a chain on three inverters is increased up to 120% and the operation frequency of ring oscillator is reduced up to 58.8% when long interconnections (l i =3 mm) are used.