Risques de la stimulation ovarienne et du prélèvement ovocytaire

Merviel, Philippe; Cabry, Rosalie; Boulard, V.; Lourdel, E.; Oliéric, M.-F.; Claeys, Coraline; Demailly, P.; Devaux, A.; Copin, Henri

doi:10.1016/j.gyobfe.2009.06.007

Cited by 7 publications

(1 citation statement)

References 61 publications

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“…Thus, IVF, which involves use of gonadotrophins, can increase the number of ovulations approximately six to nine times that of untreated women (33), as compared to only a doubling for clomiphene (34;35). In addition, IVF often involves repeated ovarian punctures and resultant trauma to the ovarian surface epithelial cells (33;36). …”

Section: Discussionmentioning

confidence: 99%

In vitro fertilization and risk of breast and gynecologic cancers: a retrospective cohort study within the Israeli Maccabi Healthcare Services

Brinton

Trabert

Shalev

et al. 2013

Fertility and Sterility

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Objective To assess long-term cancer risks associated with in vitro fertilization (IVF). Design Record-linkage study Setting Health maintenance organization in Israel Patients 87,403 women evaluated and/or treated for infertility on or after September 25, 1994 who were followed for cancer development through June 22, 2011: 522 breast, 41 endometrial, 45 ovarian, 311 in situ cervical and 32 invasive cervical cancers were identified. Intervention(s) None Main Outcome Measures Hazard ratios (HRs) for specific cancers Results We found no significant relationships of IVF exposures to the risks of breast, endometrial or ovarian cancers. Compared to women with no fertility treatment, the HR for ovarian cancer associated with IVF was 1.58 (95% CI 0.75–3.29), with higher risk among those receiving 4+ cycles (1.78, 95% CI 0.76–4.13). There was also a non-significantly elevated risk for endometrial cancer among women who received 1–3 IVF cycles (1.94, 0.73–5.12), but additional cycles were associated with lesser risk. In contrast, the risk of in situ cervical cancer was significantly reduced and invasive cervical cancer non-significantly reduced among women receiving IVF as well as other fertility treatments. Conclusions Our results regarding long-term effects were largely reassuring, but women receiving IVF should continue to be monitored given that the procedures involves potent ovulation stimulators and repeated ovarian punctures.

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