Cabergoline for preventing ovarian hyperstimulation syndrome

Calcium Dobesilate versus Cabergoline for Prevention of Ovarian Hyper Stimulation Syndrome

“…hydroxyethyl starch, prednisolone or ' coasting' (withholding anymore ovarian stimulation for a few days). However, coasting had a lower pregnancy rate than cabergoline [32].…”

“…Tang et al [28] in their Cochrane Review of 230 women in 2 RCTs found cabergoline to be effective in significantly reducing the incidence of moderate OHSS (OR 0.38; 95% CI 0.19-0.78) with no significant effect on clinical pregnancy rate and miscarriage rates. A recent systemic review by Leitao et al [29] on the issue, which considered 7 RCTs, has further established its efficacy in preventing the occurrence of moderate and severe OHSS (RR 0.38; 95% CI 0.29-0.51) as well as without a negative impact on clinical pregnancy or oocytes retrieved.…”

Aromatase Inhibitor for Prevention of Ovarian Hyperstimulation Syndrome(OHSS)

“…The best strategy to prevent OHSS is to identify the patients at risk [17,18], such as women with polycystic ovaries, low body mass index, high serum LH levels, high follicular recruitment and high level of serum E2. Several strategies to reduce the risk of severe OHSS have been described [19][20][21][22][23][24][25][26][27]. The appropriate stimulation protocol and gonadotropin dose need to be selected.…”

“…The appropriate stimulation protocol and gonadotropin dose need to be selected. Even then when patient found hyperstimulated, gonadotropin dose reduction, coasting (withholding gonadotropin), use of cabergoline, cycle cancellation, reduction of hCG dose, deferment of ET and administration of intravenous albumin during or immediately after ovum pick up has been shown to prevent or to reduce the severity of OHSS [6,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. Omission of hCG as a result cancellation of cycle is the simplest and safest method of prevention [37].…”

Pre-hCG variables associated with occurrence of ascites in IVF/ICSI patients at moderate risk of developing OHSS: A pilot investigation

“…Assessment of variables that can identify these patients before triggering of final follicular maturation may therefore help clinicians to undertake secondary preventive methods including coasting, reduction of the hCG dose or use of GnRH agonist for triggering of final follicular maturation, use of dopamine agonist, freezing of all embryos, or withholding of hCG and cycle cancellation [8,9,[26][27][28][29].…”