Risque résiduel de transmission du VIH et du VHB par transfusion sanguine entre 2003 et 2005 au Centre national de transfusion sanguine de Dakar (Sénégal)

Toure-Fall, A. O.; Diéye, Tandakha Ndiaye; Sall, Abibatou; Diop, M; Seck, Mame Cheikh; Diop, S.N.; Thiam, Doudou; Diakhaté, L

doi:10.1016/j.tracli.2009.09.005

Cited by 25 publications

(18 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Serological windows were obtained from literature data: 22 days for HIV, 56 days for HBV and 66 for HCV [9] [11].…”

Section: Discussionmentioning

confidence: 99%

“…This observation is the same for the rest of the country. The DRC has a national blood transfusion center in the capital, with 11 provincial centers, one in each province is still far to collect donations of blood meets the needs as is the case in other African countries Saharan [9] [17] [18]. In 2011 for a population of nearly 70 millions, 372,258 blood bags were collected.…”

Section: Discussionmentioning

confidence: 99%

“…The explanation is that in this group of the population (blood donors and men less than 30 years), certain practices such as scarification and tattooing for various reasons may be the cause of the infections [21]. The organization of awarenessraising about the modes of transmission of this virus could probably play a role in reducing the incidence rate [9]. All blood donations with a positive infectious marker were discarded.…”

Section: Discussionmentioning

confidence: 99%

“…Despite an evolution and improvement of all these measures, the residual risk is still too high. This is a risk of transmission of viruses whose markers (antibodies) are detected during the period preceding their appearance to be detected in the laboratory [9]- [12]. The strategy of the qualification and selection of blood donors has shown good results with the reduction of the residual risk of viral markers in industrialized countries [11] [13].…”

Section: Introductionmentioning

confidence: 99%

“…A direct estimation of the transfusion risk would be recipient's follow-up to study the seroconversion; and indirect estimation is proposed by Schreiber [15] method, based on the incidence of each viral infection in the population of blood donors and the duration of the window period. These residual risk assessments have shown that in industrialized countries the risk is mastered in France without genomic screening, the risk was estimated to 1/1,400,000 donations for HIV 1/1,000,000 for HCV and 1/400,000 for HBV [11] while in Africa it is high in the order of 1/5780 donations for HIV, 1/406 donations for HCV and 1/383 donations for HBV in Ivory Coast [16] and 1/28,571 donations for HIV and 1/976 donations for the HBV Senegal [9]. This study aims to determine the incidence rate of HIV, HBV and HCV and to estimate the residual risk of HIV, HBV and HCV among voluntary blood donors in Bukavu RDC.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Residual Risk of Transmission of HIV and Hepatitis B and C by Blood Transfusion in Bukavu in the Democratic Republic of Congo

Kabinda¹,

Bulabula²,

Donnen³

et al. 2014

OJEpi

View full text Add to dashboard Cite

The aim of this study was to determine the incidence rates of HIV1/2 antibodies, HBV and HCV antibodies among voluntary blood donors and to estimate the residual risk of HIV, HBV and HCV infection among blood donors in Bukavu. We conducted a follow-up cohort study of volunteer blood donors who have made at least two blood donations in Bukavu (DRC) between January 2010 and December 2012. We recorded 2986 volunteer blood donors during the study period. The residual risk of viral transmission associated with the serological window was considered as equals to the incidence rate multiplied by the duration of the serological window period divided by 365. Seroprevalence in volunteer blood donors in Bukavu was 1.1% for HIV 1/2 antibodies, 4.0% for HBs Ag and 2.1% for hepatitis C antibody. The number of conversion between two blood donations (incident cases) were observed is 8, 12 and 37 donors respectively for HIV 1/2, HCV and hepatitis B between 2010 and 2012. Incidence rates reported for 1000 person-years were 11.0 for HIV, 51.7 for HBV and 17.1 for HCV. The residual risk as estimated from the window was 0.6 per 1000 donations or 1/1.515 donations for HIV, 3.1 per 1000 donations or 1/329 for HCV and 7.9 per 1000 donations or 1/126 donations for hepatitis B. The residual risk is high. The screening tests are not * Corresponding author. J. M. Kabinda et al. 158enough to ensure safe blood. The reduction of residual risk would be achieved through the effectiveness of preventive measures taken for transfusion chain, before and after the biological qualification of blood donation.

show abstract

“…Serological windows were obtained from literature data: 22 days for HIV, 56 days for HBV and 66 for HCV [9] [11].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%