Risks of Carotid Artery Stenosis and Atherosclerotic Cardiovascular Disease in Patients with Calcium Kidney Stone: Assessment of Systemic Inflammatory Biomarkers

Liu, Chan Jung; Jan, Hau-Chern; Huang, Huey W.

doi:10.3390/jpm12101697

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…The authors concluded that red blood cell distribution width and NLR could serve as predictors of traditional and novel markers of vascular calcification and CV disease [20]. Similarly, in a study that enrolled 74 patients, calcium kidney stones were associated with higher levels of inflammatory biomarkers, including NLR, MLR, and SIRI, compared with ageand sex-matched non-stone formers [21]. Also, in this report, after stratification by CV risk category, all inflammatory biomarkers and the severity of carotid artery stenosis were still significantly higher in calcium stone formers.…”

Section: Discussionmentioning

confidence: 97%

Relationship of Blood Inflammatory Composite Markers with Cardiovascular Risk Factors and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis

González-Sierra,

Quevedo-Rodríguez,

Romo-Cordero

et al. 2023

Life

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The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SIRI, neutrophils × monocytes/lymphocytes) have been described as potential blood-derived inflammatory biomarkers in several diseases. Rheumatoid arthritis is an inflammatory disease that has been related to an increased risk of cardiovascular (CV) disease. In the present work, we analyze how these hematological composite scores of inflammation are related to classic CV risk factors and subclinical atherosclerosis in patients with RA. In this cross-sectional study that included 430 patients with RA, the NLR, MLR, PLR, and SIRI scores were calculated. Multivariable analysis was performed to examine the relationships of these composite blood scores with subclinical carotid atherosclerosis and with traditional cardiovascular factors, producing a complete profile of lipid molecules and insulin resistance or indices of beta-cell function, and a Systematic Coronary Risk Assessment (SCORE2) calculation. C-reactive protein and disease activity were significantly and positively associated with the four blood composite scores. SCORE2 was significantly associated with higher values of SIRI, NLR, and MLR, but not PLR. These relationships were maintained when SCORE 2 was considered categorical; patients in the very high CV risk category had higher values in all hematological composite scores, except PLR. In the multivariable analysis, SIRI and NLR were independently associated with higher levels of beta cell dysfunction. In conclusion, SCORE2 and the values of the hematological composite scores were positively correlated in patients with RA. In addition, there were some relationships of these scores with traditional CV risk factors, with their association with beta cell dysfunction being the most consistent.

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Section: Discussionmentioning

confidence: 97%