Epidemiological and biological associations between cardiovascular disease and kidney stone formation: A systematic review and meta-analysis

Muschialli, Luke; Mannath, Ankith; Moochhala, Shabbir H.; Shroff, Rukshana; Ferraro, Pietro Manuel

doi:10.1016/j.numecd.2023.09.011

Cited by 2 publications

(6 citation statements)

References 32 publications

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“…In this study, it has been shown how females show a higher risk of CHD. This feature has already been described by other metanalyses in which it has been showed that the association between urolithiasis and coronary artery disease was higher in women (pooled HR = 1.43) compared to men (pooled HR = 1.19) [4], as well as a higher risk of suffering MI (RR = 1.37) [2]. Conversely, the differences between sexes were not significant when considering cerebrovascular disease, contrasting with a previous analysis that reported a slightly higher prevalence of stroke in women (RR = 1.12) [2] (HR = 1.2) [4].…”

Section: Discussionsupporting

confidence: 80%

“…Experimental and clinical approaches have also shown that endothelial dysfunction is persistently developed in patients with kidney stones and in various experimental models [ 11 , 21 , 23 , 24 ]. A slight relationship between the stone disease and the development of CVD and cerebrovascular disease in which hazard ratios range between 1.1 and 1.5 has also been widely shown using different epidemiological approaches [ 1 , 2 , 3 , 4 ]. However, no earlier studies have been developed based on large national registries.…”

Section: Discussionmentioning

confidence: 99%

“…Our data show a higher influence of the stone disease on the CHD development compared to the data reported so far, in which the relative risk of developing CHD is slightly higher than the general population (RR: 1.2–1.25). Four metanalyses have been reported so far [ 1 , 2 , 3 , 4 ]. The most recent one includes eight studies that report a significant relationship between kidney stones and CHD, although substantial heterogeneity was detected.…”

Section: Discussionmentioning

confidence: 99%

“…25. Similarity, stroke has also been correlated with urolithiasis, presenting relative risks ranging from 1.17 to 1.40 [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…Coronary heart disease (CHD) relative risk specifically associated with kidney stones has been established to be between 1.20 and 1.25. Similarity, stroke has also been correlated with urolithiasis, presenting relative risks ranging from 1.17 to 1.40 [ 1 , 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Cardiovascular and Cerebrovascular Morbidity in Patients with Urolithiasis: An Epidemiological Approach Based on Hospitalization Burden Data from 1997 to 2021

Sáenz-Medina,

Gómez Dos Santos,

Rodríguez-Monsalve

et al. 2024

JCM

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Background: Patients with kidney stones (KSFs) are known to have a heightened risk of coronary heart disease (CHD) or stroke. The objective of the present study was to describe the natural history of these complications through the longitudinal analysis of the hospitalizations due to kidney stones in Spain from 1997 to 2021. Methods: A retrospective longitudinal observational study was developed based on nationwide hospitalization data (minimum basic data base). Three different analyses were carried out. In the first step, the prevalence of coronary or cerebrovascular events in kidney stone hospitalizations was compared with the hospitalization burden of CHD or strokes related to the general population. In the second step, a survival analysis of the kidney stones–hospitalized patients using the Kaplan–Meier method was conducted. In the third step, a Cox regression was used to assess the influence of the classical comorbidities in the development of the lithiasic patients–cardiovascular disease. Results: Kidney stone-hospitalized patients exhibit a significantly higher risk of CHD (OR = 14.8 CI95%: 14.7–14.9) and stroke (OR = 6.7 CI95%: 6.6–6.8) compared to the general population across in all age groups, although they had less cardiovascular risk factors. A total of 9352 KSFs (1.5%) developed a coronary event within an average time of 78.8 months. A total of 2120 KSFs (0.33%) suffered a stroke in an average time of 71.1 months. Diabetes, hypertension, hyperlipidemia, and being overweight were identified as risk factors for developing CHD and stroke using a univariate and multivariate analysis. Conclusions: Our study confirms previous studies in which kidney stones must be considered as a risk factor for developing CHD or cerebrovascular disease. Preventive strategies should target patients with kidney stones and classical risk cardiovascular factors to mitigate modifiable conditions associated with cardiovascular diseases.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…25. Similarity, stroke has also been correlated with urolithiasis, presenting relative risks ranging from 1.17 to 1.40 [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cardiovascular and Cerebrovascular Morbidity in Patients with Urolithiasis: An Epidemiological Approach Based on Hospitalization Burden Data from 1997 to 2021

Sáenz-Medina,

Gómez Dos Santos,

Rodríguez-Monsalve

et al. 2024

JCM

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Sleep and circadian rhythm disturbance in kidney stone disease: a narrative review

He,

Wang,

et al. 2023

Front. Endocrinol.

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The circadian rhythm generated by circadian clock genes functions as an internal timing system. Since the circadian rhythm controls abundant physiological processes, the circadian rhythm evolved in organisms is salient for adaptation to environmental change. A disturbed circadian rhythm is a trigger for numerous pathological events. Recently, accumulated data have indicated that kidney stone disease (KSD) is related to circadian rhythm disturbance. However, the mechanism between them has not been fully elucidated. In this narrative review, we summarized existing evidence to illustrate the possible association between circadian rhythm disturbance and KSD based on the epidemiological studies and risk factors that are linked to circadian rhythm disturbance and discuss some chronotherapies for KSD. In summary, KSD is associated with systemic disorders. Metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis are the major risk factors supported by sufficient data to cause KSD in patients with circadian rhythm disturbance, while others including hypertension, vitamin D deficiency, parathyroid gland dysfunction, and renal tubular damage/dysfunction need further investigation. Then, some chronotherapies for KSD were confirmed to be effective, but the molecular mechanism is still unclear.

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Epidemiological and biological associations between cardiovascular disease and kidney stone formation: A systematic review and meta-analysis

Cited by 2 publications

References 32 publications

Cardiovascular and Cerebrovascular Morbidity in Patients with Urolithiasis: An Epidemiological Approach Based on Hospitalization Burden Data from 1997 to 2021

Cardiovascular and Cerebrovascular Morbidity in Patients with Urolithiasis: An Epidemiological Approach Based on Hospitalization Burden Data from 1997 to 2021

Sleep and circadian rhythm disturbance in kidney stone disease: a narrative review

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