Risk to all or none?

Beronius, Anna; Rudén, Christina; Håkansson, Helen; Hanberg, Annika

doi:10.1016/j.reprotox.2009.11.007

Cited by 124 publications

(44 citation statements)

References 41 publications

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“…The population may be exposed to BPA from fetal life to adulthood (Cobellis et al, 2009;Vandenberg et al, 2010;Braun and Hauser, 2011;Koch et al, 2012). Many reports claim that it belongs to the growing list of so-called endocrine-disrupting chemicals (EDC; Beronius et al, 2010;Teeguarden and Hanson-Drury, 2013). Decision of a number of regulatory agencies to ban BPA from food packaging has led to the gradual development of a number of bisphenol analogs (BPA-A) to replace BPA in several applications.…”

Section: Introductionmentioning

confidence: 99%

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

et al. 2017

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WHAT IS KNOWN ALREADY:The few epidemiologic studies performed suggest that bisphenols have potential endocrine disruptive properties, but they did not identify clear and direct patterns of endocrine disruption. STUDY DESIGN, SIZE, DURATION:Adult human testis explants in culture were exposed to BPA and the analogs bisphenol F (BPF), bisphenol S (BPS), bisphenol E (BPE), bisphenol B (BPB), and bisphenol A diglycidyl ether (BADGE) at 10 -9 to 10 -5 M for 24 h or 48h.PARTICIPANTS/MATERIALS, SETTING, METHODS: Human adult testes were obtained from prostate cancer patients who had no hormone therapy, or from multiorgan donors. After ex vivo exposure to the investigated bisphenols, the measured outcomes were related to histopathology (gross morphology and germ cell viability determined by anti-caspase 3 immunohistochemistry), and the levels of testosterone, insulin-like fator 3 and inhibin B were measured using immunoassays. The levels of mRNA encoding key enzymes of bisphenol biotransformation were investigated by quantitative PCR: UGT2B15 UDP (glucuronosyltransferase two family, polypeptide B15), GUSB (glucuronidase beta), SULT1A1 and 3 (sulfotransferase family 1 A member 1 and 3) and STS (steroid sulfatase). MAIN RESULTS AND THE ROLE OF CHANCE: A significant dose-dependent inhibition wasfound between testosterone levels measured in the culture medium and concentrations of BPA The active concentrations of BPA and BPA-A used in the study were higher than those found in human biological fluids. WIDER IMPLICATIONS OF THE FINDINGS:Under our experimental conditions, direct exposure to BPA or BPA-A can result in endocrine disturbance in the adult human testis.

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Section: Introductionmentioning

confidence: 99%

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

et al. 2017

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“…Designed to draw upon the strengths of academic and guideline-compliant studies in order to address research gaps and confirm prior findings, this and all other CLARITY-BPA studies are uniquely powerful because they incorporate research recommendations published by the WHO and others (Beronius et al, 2010; Beronius et al, 2009; Chapin et al, 2008; FAO/WHO, 2011; FDA, 2012; NTP, 2008) for enhancing robustness and reproducibility, including complete data blinding, use of only one animal per sex per litter (with the litter as the experimental unit), oral dosing, inclusion of a reference estrogen, and evaluation of multiple BPA doses, particularly levels at or below the FDA NOAEL. Additionally, as in our prior, published CLARITY-BPA studies (Arambula et al, 2016; Rebuli et al, 2015), sex was considered as a biological variable.…”

Section: Introductionmentioning

confidence: 99%

Effects of perinatal bisphenol A exposure on the volume of sexually-dimorphic nuclei of juvenile rats: A CLARITY-BPA consortium study

et al. 2017

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Bisphenol A (BPA) is a high volume endocrine disrupting chemical found in a wide variety of products including plastics and epoxy resins. Human exposure is nearly ubiquitous, and higher in children than adults. Because BPA has been reported to interfere with sex steroid hormone signaling, there is concern that developmental exposure, even at levels below the current FDA No Observed Adverse Effect Level (NOAEL) of 5 mg/kg body weight (bw)/day, can disrupt brain sexual differentiation. The current studies were conducted as part of the CLARITY-BPA (Consortium Linking Academic and Regulatory Insights on BPA Toxicity) program and tested the hypothesis that perinatal BPA exposure would induce morphological changes in hormone sensitive, sexually dimorphic brain regions. Sprague-Dawley rats were randomly assigned to 5 groups: BPA (2.5, 25, or 2500 µg/kg bw/day), a reference estrogen (0.5 µg ethinylestradiol (EE2)/kg bw/day), or vehicle. Exposure occurred by gavage to the dam from gestational day 6 until parturition, and then to the offspring from birth through weaning. Unbiased stereology was used to quantify the volume of the sexually dimorphic nucleus (SDN), the anteroventral periventricular nucleus (AVPV), the posterodorsal portion of the medial amygdala (MePD), and the locus coeruleus (LC) at postnatal day 28. No appreciable effects of BPA were observed on the volume of the SDN or LC. However, AVPV volume was enlarged in both sexes, even at levels below the FDA NOAEL. Collectively, these data suggest the developing brain is vulnerable to endocrine disruption by BPA at exposure levels below previous estimates by regulatory agencies.

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“…Bisphenol A (BPA), a monomer used in epoxy sealants and plastics, has become ubiquitous in our environment and bodies, prompting concerns about its potential health impacts especially on neural development and behavior (Beronius et al, 2010; Chapin et al, 2008; FAO/WHO, 2011; FDA, 2012). Understanding how environmental factors, including endocrine disrupting chemicals (EDCs) such as BPA, contribute to impairments in affective and reciprocal social behaviors, are of considerable interest because they are features of psychosocial disorders for which incidence is rapidly rising, including autism spectrum disorders (ASDs) (Aguiar et al, 2010; Gore et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Interaction of bisphenol A (BPA) and soy phytoestrogens on sexually dimorphic sociosexual behaviors in male and female rats

Hicks

Sullivan

Cao

et al. 2016

Hormones and Behavior

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Concerns have been raised regarding the potential for endocrine disrupting compounds (EDCs) to alter brain development and behavior. Developmental exposure to bisphenol A (BPA), a ubiquitous EDC, has been linked to altered sociosexual and mood-related behaviors in various animal models and children but effects are inconsistent across laboratories and animal models creating confusion about potential risk in humans. Exposure to endocrine active diets, such as soy, which is rich in phytoestrogens, may contribute to this variability. Here, we tested the individual and combined effects of low dose oral BPA and soy diet or the individual isoflavone genistein (GEN; administered as the aglycone genistin (GIN)) on rat sociosexual behaviors with the hypothesis that soy would obfuscate any BPA-related effects. Social and activity levels were unchanged by developmental exposure to BPA but soy diet had sex specific effects including suppressed novelty preference, and open field exploration in females. The data presented here reinforce that environmental factors, including anthropogenic chemical exposure and hormone active diets, can shape complex behaviors and even reverse expected sex differences.

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Risk to all or none?

Cited by 124 publications

References 41 publications

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

Effects of perinatal bisphenol A exposure on the volume of sexually-dimorphic nuclei of juvenile rats: A CLARITY-BPA consortium study

Interaction of bisphenol A (BPA) and soy phytoestrogens on sexually dimorphic sociosexual behaviors in male and female rats

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