Risk-stratification system for pre-operative evaluation

The statistical significance may be mis-interpretated

“…In our limited knowledge, stage may be the most importantly independent prognostic factors for all solid tumors. 2–5 In fact, the authors have clearly demonstrated the strong correlation between the high NLRP12 expression and advanced stage of intracranial glioma, suggesting that the expression of NLRP12 may depend on the tumor stage or vice versa.…”

Is it possible that advanced-stage gastric cancer patients can be cured by surgery alone?

“…1 The spread of molecular pathology has paved the way for patient-tailored strategies, with the aim of improving short-and long-term outcomes. 6,7,9 Overall, we appreciate the authors' great work exploring the limitation of conventional clinicopathological parameters in the prediction of outcomes in GC patients who were treated with curative surgery. Surgery still represents the mainstay of treatment of all stages of GC, 6 similar to our experience in the management of uterine cancers.…”

“…The optimal therapeutic goal of adjuvant therapy had better include the more confidence to the curative surgery, a better chance to minimize the damage to the surrounding tissue or systemic toxicity to human bodies, and subsequently, a higher quality of life after initial curative therapy. 7,8 Despite aforementioned questions, the authors' attempt to integrate the molecular pathology into the conventional clinicopathological parameters in the prediction of GC patients is worthy of encouragement. 1 The spread of molecular pathology has paved the way for patient-tailored strategies, with the aim of improving short-and long-term outcomes.…”

“…The optimal therapeutic goal of adjuvant therapy had better include the more confidence to the curative surgery, a better chance to minimize the damage to the surrounding tissue or systemic toxicity to human bodies, and subsequently, a higher quality of life after initial curative therapy. 7,8…”

Molecular pathology-integrated clinicopathological prognostic factors

“…2 However, few patients with proposed curable diseases may recur later even though the initial primary active and curative treatment is given, and subsequently die of diseases, suggesting that an accurate and precise evaluation and appropriate and personalized therapeutic plan to those patients with supposedly curable diseases by far-advanced development of new technology or therapeutic strategy is critically important. 10,11 All efforts make the diseases with a maximal chance for curability. The article published in the January issue of the Journal of the Chinese Medical Association entitled “The clinicopathological and genetic differences among gastric cancer patients with no recurrence, early recurrence, and late recurrence after curative surgery” attempted to explore this topic, since the authors’ enrolled subjects belonged to complete resection of tumors and all of them received the curable surgery claimed by authors.…”