Risk Stratification of Patients Candidate to Radical Prostatectomy Based on Clinical and Multiparametric Magnetic Resonance Imaging Parameters: Development and External Validation of Novel Risk Groups

Mazzone, Elio; Gandaglia, Giorgio; Ploussard, Guillame; Marra, Giancarlo; Valério, Massimo; Campi, Riccardo; Mari, Andrea; Serni, Sergio; Moschini, Marco; Marquis, Alessandro; Beauval, Jean Baptiste; Bergh, Roderick van den; Rahota, Razvan-George; Soeterik, Timo; Roumiguié, M.; Afferi, Luca; Zhuang, Junlong; H, Guo; Mattei, Agostino; Gontero, Paolo; Cucchiara, Vito; Stabile, Armando; Fossati, Nicola; Montorsi, Francesco; Briganti, Alberto

doi:10.1016/j.eururo.2021.07.027

Cited by 39 publications

(36 citation statements)

References 32 publications

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“…Tools to estimate post-operative disease recurrence are limited in their accuracy [ 2 ]. Incorporation of novel imaging is a natural progression to improve predictive tools.…”

Section: Discussionmentioning

confidence: 99%

“…Incorporation of novel imaging is a natural progression to improve predictive tools. Mazzone and colleagues showed mpMRI features in combination with biopsy GS, and PSA improved predictive accuracy compared to other classification methods [ 2 ]. Molecular tests, such as the Decipher® genomic classifier, are independently prognostic for oncological outcomes [ 1 ]; however, these tests are not commonly available outside the USA.…”

Section: Discussionmentioning

confidence: 99%

“…These variables include serum prostate-specific antigen (PSA), clinical stage and histological characteristics including Gleason score (GS), the proportion of positive biopsy cores, radical prostatectomy (RP) pathological stage, and surgical margin status[ 1 ]. The incorporation of modern imaging techniques, such as multiparametric MRI (mpMRI), has improved predictive accuracy for recurrent disease, but only to approximately 70% [ 2 ] so further improvements are needed.…”

Section: Introductionmentioning

confidence: 99%

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Primary tumour PSMA intensity is an independent prognostic biomarker for biochemical recurrence-free survival following radical prostatectomy

Roberts

Morton

Papa

et al. 2022

Eur J Nucl Med Mol Imaging

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Purpose The prognostic value of PSMA intensity on PSMA PET/CT due to underlying biology and subsequent clinical implications is an emerging topic of interest. We sought to investigate whether primary tumour PSMA PET intensity contributes to pre- and post-operative prediction of oncological outcomes following radical prostatectomy. Methods We performed a retrospective cohort study of 848 men who underwent all of multiparametric MRI (mpMRI), transperineal prostate biopsy, and 68 Ga-PSMA PET/CT prior to radical prostatectomy. PSMA intensity, quantified as maximum standard uptake value (SUVmax), and other clinical variables were considered relative to post-operative biochemical recurrence-free survival (BRFS) using Cox regression and Kaplan–Meier analysis. Results After a median follow-up of 41 months, 219 events occurred; the estimated 3-year BRFS was 79% and the 5-year BRFS was 70%. Increasing PSMA intensity was associated with less favourable BRFS overall (Log rank p < 0.001), and within subgroups of Gleason score category (Log rank p < 0.03). PSMA intensity was significantly associated with shorter time to biochemical recurrence, after adjusting for pre-operative (HR per 5-unit SUVmax increase = 1.15) and post-operative (HR per 5-unit SUVmax increase = 1.10) parameters. Conclusion These results in a large series of patients confirm PSMA intensity to be a novel, independent prognostic factor for BRFS.

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“…Tools to estimate post-operative disease recurrence are limited in their accuracy [ 2 ]. Incorporation of novel imaging is a natural progression to improve predictive tools.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary tumour PSMA intensity is an independent prognostic biomarker for biochemical recurrence-free survival following radical prostatectomy

Roberts

Morton

Papa

et al. 2022

Eur J Nucl Med Mol Imaging

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“…In addition, there is a clear need to improve our ability to enhance PCa patients at high risk of metastasis and recurrence after radical prostatectomy for PCa. The challenge of accurately predicting PCa metastasis and recurrence may be partially attributed to the complex pathways that promote disease development ( 19 ). CDCA8 plays a vital role in various tumor-related processes.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of CDCA8 Predicts Poor Prognosis and Promotes Tumor Cell Growth in Prostate Cancer

Wan

Zhang

et al. 2022

Front. Oncol.

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Human cell division cycle-related protein 8 (CDCA8) is an essential component of the vertebrate chromosomal passenger complex (CPC). CDCA8 was confirmed to play a role in promoting malignant tumor progression. However, the exact function of CDCA8 in the development and progression of prostate cancer (PCa) remains unclear. In this study, the database GSE69223 was downloaded by the gene expression omnibus (GEO) database, as well as CDCA8 expression differences in multiple tumor tissues and normal tissues were detected by The Cancer Genome Atlas (TCGA), TIMER, Oncomine, and Ualcan databases. Kaplan-Meier and Cox regression methods were used to analyze the correlation between CDCA8 expression and prognosis in PCa. We confirmed the expression of CDCA8 in PCa tissues by HPA. We also analyzed the association of CDCA8 expression with PCa clinical characteristics in the TCGA database. To further understand the role of CDCA8 in PCa, we assessed the effects of CDCA8 on PCa cell growth, proliferation, and migration in vitro studies. As a result, CDCA8 was significantly overexpressed in PCa cells compared with normal prostate cells. High CDCA8 expression predicts poor prognosis in PCa patients, and CDCA8 expression was higher in high-grade PCa. In addition, silencing of CDCA8 significantly inhibited PCa cell proliferation and migration. In summary, CDCA8 promoted the proliferation and migration of PCa cells.

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“…However, the majority of these studies focus on weak surrogates of cancer-specific survival (CSS) (e.g., BCR which is an early and easily measured endpoint) [ 11 ] and a recent meta-analysis validated the MFS as a more meaningful clinical endpoint and the only identified surrogate endpoint for overall survival (OS) in localized PC [ 12 ]. New predictive biomarkers are then needed to complement available clinical, histological, and radiological data (i.e., magnetic resonance imaging) [ 13 ] and to accurately predict MFS and CSS.…”

Section: Introductionmentioning

confidence: 99%

High Keratin-7 Expression in Benign Peri-Tumoral Prostatic Glands Is Predictive of Bone Metastasis Onset and Prostate Cancer-Specific Mortality

Dariane

Clairefond

Péant

et al. 2022

Cancers

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Background: New predictive biomarkers are needed to accurately predict metastasis-free survival (MFS) and cancer-specific survival (CSS) in localized prostate cancer (PC). Keratin-7 (KRT7) overexpression has been associated with poor prognosis in several cancers and is described as a novel prostate progenitor marker in the mouse prostate. Methods: KRT7 expression was evaluated in prostatic cell lines and in human tissue by immunohistochemistry (IHC, on advanced PC, n = 91) and immunofluorescence (IF, on localized PC, n = 285). The KRT7 mean fluorescence intensity (MFI) was quantified in different compartments by digital analysis and correlated to clinical endpoints in the localized PC cohort. Results: KRT7 is expressed in prostatic cell lines and found in the basal and supra-basal compartment from healthy prostatic glands and benign peri-tumoral glands from localized PC. The KRT7 staining is lost in luminal cells from localized tumors and found as an aberrant sporadic staining (2.2%) in advanced PC. In the localized PC cohort, high KRT7 MFI above the 80th percentile in the basal compartment was significantly and independently correlated with MFS and CSS, and with hypertrophic basal cell phenotype. Conclusion: High KRT7 expression in benign glands is an independent biomarker of MFS and CSS, and its expression is lost in tumoral cells. These results require further validation on larger cohorts.

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Risk Stratification of Patients Candidate to Radical Prostatectomy Based on Clinical and Multiparametric Magnetic Resonance Imaging Parameters: Development and External Validation of Novel Risk Groups

Cited by 39 publications

References 32 publications

Primary tumour PSMA intensity is an independent prognostic biomarker for biochemical recurrence-free survival following radical prostatectomy

Primary tumour PSMA intensity is an independent prognostic biomarker for biochemical recurrence-free survival following radical prostatectomy

Overexpression of CDCA8 Predicts Poor Prognosis and Promotes Tumor Cell Growth in Prostate Cancer

High Keratin-7 Expression in Benign Peri-Tumoral Prostatic Glands Is Predictive of Bone Metastasis Onset and Prostate Cancer-Specific Mortality

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