High Keratin-7 Expression in Benign Peri-Tumoral Prostatic Glands Is Predictive of Bone Metastasis Onset and Prostate Cancer-Specific Mortality

Dariane, C.; Clairefond, Sylvie; Péant, Benjamin; Communal, Laudine; Thian, Zhe; Ouellet, Véronique; Trudel, Dominique; Benzerdjeb, Nazim; Azzi, Féryel; Méjean, A.; Timsit, Marc‐Olivier; Baurès, Manon; Guidotti, Jacques-Emmanuel; Goffin, Vincent; Karakiewicz, Pierre I.; Mes-Masson, Anne-Marie; Saad, Fred

doi:10.3390/cancers14071623

Cited by 6 publications

(1 citation statement)

References 58 publications

(100 reference statements)

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“…Additionally, only 10% of samples showed positive expression of Ck-7 (21,22). Interestingly, the results of the study of Dariane et al showed that Ck-7 is expressed in normal prostate tissue and benign glands around the tumor, mainly in the cells of the basal and suprabasal layers, but it is not present in the luminal cells of the tumor (23). Therefore, the expression of Ck-7 decreases during the development of PAC.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cytokeratin-7 and Cytokeratin-19 Expression Relationship with Gleason Score in Prostatic Adenocarcinoma

Soltanipur,

Jalali Nadoushan,

Yarmohammadi

2023

Iran J Pathol

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Background & Objective: Prostatic adenocarcinoma (PAC) is one of the most common tumors worldwide. Immunohistochemical expression of cytokeratins has been evaluated in the diagnosis and prognosis of tumors. The aim of the present study is the evaluation of Cytokeratin-7 (Ck-7) and Cytokeratin-19 (Ck-19) expression and its relationship with Gleason score in patients with PAC. Methods: In this cross-sectional study, 78 samples from 78 patients with PAC referred to Mostafa Khomeini Hospital were gathered. Samples were immunohistochemically stained by Ck-7 and Ck-19 markers. The percentage of each marker in tumor cells was determined, and its relationship with Gleason scores and Gleason grade groups was analysed by SPSS version 24. Results: The expression of Ck-7 and Ck-19 were seen in 37.2% and 82.1% of samples, respectively. The mean of Ck-7 expression in tumor cells was 4.98%±7.19 (ranged 0 to 26%), while the mean of Ck-19 expression was 41.02%±23.36 (ranged 0 to 78%). There was no relationship between Ck-7 expression with Gleason scores and Gleason grade groups. However, Ck-19 expression was increased in higher Gleason scores and Gleason grade groups ( P <0.001). No relationship was found between age and Ck-7 ( P =0.309) and Ck-19 ( P =0.375). Conclusion: The Ck-7 expression in PAC samples is weak and focal and had no relationship with the Gleason scores and Gleason grade groups. However, Ck-19 expression in PAC was high and was associated with tumor dedifferentiation of samples. There was no relationship between the expression of both markers with the patient's age.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Cytokeratin-7 and Cytokeratin-19 Expression Relationship with Gleason Score in Prostatic Adenocarcinoma

Soltanipur,

Jalali Nadoushan,

Yarmohammadi

2023

Iran J Pathol

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Keratin7 and Desmoplakin are involved in acute lung injury induced by sepsis through RAGE

He,

Zuo,

Song

et al. 2023

International Immunopharmacology

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Keratin 7 expression in different anatomical parts of colonic epithelium in inflammatory bowel diseases and its prognostic value: a 3-year follow-up study

Tenhami¹,

Polari²,

Kujari³

et al. 2023

Sci Rep

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The diagnosis of inflammatory bowel diseases (IBD) may be challenging and their clinical course, characterized by relapses and spontaneous or drug-induced remissions, is difficult to predict. Novel prognostic biomarkers are needed. Keratin 7 (K7) is a cytoskeletal intermediate filament protein which is not normally expressed in the colonic epithelium. It was recently shown that K7 expression in the colonic epithelium is associated with ulcerative colitis and Crohn’s disease, the two main subtypes of IBD. Here we investigated IBD associated K7 neo-expression in different regions of colon and terminal ileum. The correlation of the K7 expression with the inflammatory activity of the epithelium was analyzed in each region. The prognostic value of K7 was estimated by comparing the clinical disease activity after 3 years with the K7 expression at the time of enrollment. Our data shows that the level of K7 expression in inflamed epithelium varies depending on the anatomical region and it is the most pronounced in ascending and descending colon, but it did not predict the severity of IBD for the following 3 years. These results warrant future studies focusing on the biological role of K7 in colon and its utilization as potential IBD biomarker.

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High Keratin-7 Expression in Benign Peri-Tumoral Prostatic Glands Is Predictive of Bone Metastasis Onset and Prostate Cancer-Specific Mortality

Cited by 6 publications

References 58 publications

Evaluation of Cytokeratin-7 and Cytokeratin-19 Expression Relationship with Gleason Score in Prostatic Adenocarcinoma

Evaluation of Cytokeratin-7 and Cytokeratin-19 Expression Relationship with Gleason Score in Prostatic Adenocarcinoma

Keratin7 and Desmoplakin are involved in acute lung injury induced by sepsis through RAGE

Keratin 7 expression in different anatomical parts of colonic epithelium in inflammatory bowel diseases and its prognostic value: a 3-year follow-up study

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