Risk Reduction of Breast Cancer by Childbirth,
Breastfeeding, and Their Interaction in Korean Women: Heterogeneous Effects Across Menopausal Status, Hormone Receptor Status, and Pathological Subtypes

Jeong, Seok Hun; An, Yoonsuk; Choi, Ji Yeob; Park, Boyoung; Kang, Daehee; Lee, Min Hyuk; Han, Wonshik; Noh, Dong Young; Yoo, Keun Young; Park, Sung Sup

doi:10.3961/jpmph.17.152

Cited by 18 publications

(9 citation statements)

References 36 publications

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“…We found its significantly increased concentration in the plasma of BC patients with high Ki-67, which is consistent with the data that miR-21 promotes BC proliferation ( Qiu et al, 2018 ; Wang et al, 2019 ). Early menarche and reduced breastfeeding are considered as risk factors for BC ( Jeong et al, 2017 ; Khalis et al, 2018 ). We found associations of both factors with elevation of miR-21-5p in plasma of Kazakh women.…”

Section: Discussionmentioning

confidence: 99%

Combination of circulating miR-145-5p/miR-191-5p as biomarker for breast cancer detection

Ashirbekov

Abaildayev

Omarbayeva

et al. 2020

PeerJ

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Background Breast cancer (BC) is the most common cancer among women worldwide. At present, there is a need to search for new, accurate, reliable, minimally invasive and cheap biomarkers in addition to existing methods for the diagnosis and prognosis of BC. The main goal of this study was to test the diagnostic value of six circulating miRNAs in Kazakh women. Materials and methods TaqMan-based miRNA profiling was conducted using plasma specimens from 35 BC women patients and 33 healthy women samples (control group). Results The level of all seven miRNAs (including endogenous control) normalized by synthetic cel-miR-39 were significantly elevated in the group of BC patients. Normalization using miR-222-3p as endogenous control reduced differences in level of miRNAs between groups; as a result, only three miRNAs were significantly upregulated in the group of BC patients—miR-145-5p (P = 6.5e−12), miR-191-5p (P = 3.7e−10) and miR-21-5p (P = 0.0034). Moreover, ROC analysis showed that the use of miR-145-5p and miR-191-5p, both individually (AUC = 0.931 and 0.904, respectively) or in combination (AUC = 0.984), allows to accurately differentiate BC patients from healthy individuals. Conclusions Two plasma miRNAs—miR-145-5p and miR-191-5p—are potential biomarkers for diagnosis of BC in the Kazakh population. The findings need to be further substantiated using a more representative sample.

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Section: Discussionmentioning

confidence: 99%

Combination of circulating miR-145-5p/miR-191-5p as biomarker for breast cancer detection

Ashirbekov

Abaildayev

Omarbayeva

et al. 2020

PeerJ

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“…The protective effect of lactation increases with increasing duration of lactation 44. The result of a case– control study showed that the combination of two protective factors (two or more childbirth and lactation for more than 13 months) could reduce the risk of developing breast cancer by up to 50% 88. Furthermore, breastfeeding may be associated with improvements in prognosis and a decreased rate of recurrence (HR, 0.70; 95% CI, 0.53–0.93) and an increased rate of survival among breast cancer patients, although this effect is different in different ER states 89.…”

Section: Risk Factorsmentioning

confidence: 99%

<p>Epidemiological characteristics of and risk factors for breast cancer in the world</p>

Momenimovahed¹,

Salehiniya²

2019

BCTT

657

471

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Aim Breast cancer is the most common cancer among women and one of the most important causes of death among them. This review aimed to investigate the incidence and mortality rates of breast cancer and to identify the risk factors for breast cancer in the world. Materials and methods A search was performed in PubMed, Web of Science, and Scopus databases without any time restrictions. The search keywords included the following terms: breast cancer, risk factors, incidence, and mortality and a combination of these terms. Studies published in English that referred to various aspects of breast cancer including epidemiology and risk factors were included in the study. Overall, 142 articles published in English were included in the study. Results Based on the published studies, the incidence rate of breast cancer varies greatly with race and ethnicity and is higher in developed countries. Results of this study show that mortality rate of breast cancer is higher in less developed regions. The findings of this study demonstrated that various risk factors including demographic, reproductive, hormonal, hereditary, breast related, and lifestyle contribute to the incidence of breast cancer. Conclusion The results of this study indicated that incidence and mortality rates of breast cancer is rising, so design and implementation of screening programs and the control of risk factors seem essential.

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“…Breastfeeding is a protective factor against breast cancer, the longer the breastfeeding, the greater the protective effect [ 27 , 28 ]. At the same time, the association of two protective factors (two or more childbirths and lactation for more than 13 months) could reduce the risk of developing breast cancer by up to 60% [ 29 , 30 ].…”

Section: Breast Cancer–incidence and Risk Factorsmentioning

confidence: 99%

PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects

Miricescu

Totan

Stănescu-Spînu

et al. 2020

IJMS

418

263

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Breast cancer is a serious health problem worldwide, representing the second cause of death through malignancies among women in developed countries. Population, endogenous and exogenous hormones, and physiological, genetic and breast-related factors are involved in breast cancer pathogenesis. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) is a signaling pathway involved in cell proliferation, survival, invasion, migration, apoptosis, glucose metabolism and DNA repair. In breast tumors, PIK3CA somatic mutations have been reported, located in exon 9 and exon 20. Up to 40% of PIK3CA mutations are estrogen receptor (ER) positive and human epidermal growth factor receptor 2 (HER2) -negative in primary and metastatic breast cancer. HER2 is overexpressed in 20–30% of breast cancers. HER1, HER2, HER3 and HER4 are membrane receptor tyrosine kinases involved in HER signaling to which various ligands can be attached, leading to PI3K/AKT activation. Currently, clinical studies evaluate inhibitors of the PI3K/AKT/mTOR axis. The main purpose of this review is to present general aspects of breast cancer, the components of the AKT signaling pathway, the factors that activate this protein kinase B, PI3K/AKT-breast cancer mutations, PI3K/AKT/mTOR-inhibitors, and the relationship between everolimus, temsirolimus and endocrine therapy.

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Risk Reduction of Breast Cancer by Childbirth, Breastfeeding, and Their Interaction in Korean Women: Heterogeneous Effects Across Menopausal Status, Hormone Receptor Status, and Pathological Subtypes

Cited by 18 publications

References 36 publications

Combination of circulating miR-145-5p/miR-191-5p as biomarker for breast cancer detection

Combination of circulating miR-145-5p/miR-191-5p as biomarker for breast cancer detection

<p>Epidemiological characteristics of and risk factors for breast cancer in the world</p>

PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects

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