Risk of tuberculosis among people with diabetes mellitus: an Australian nationwide cohort study

Dobler, Claudia C.; Flack, J.; Marks, Guy B.

doi:10.1136/bmjopen-2011-000666

Cited by 82 publications

(97 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diabetes has also been associated with tuberculosis in several studies (5)(6)(7)(8) and has been shown to be a risk factor for severe gram-positive infections (9,10), hospital-acquired postoperative infections (11,12), and urinary tract infections (3).…”

mentioning

confidence: 99%

Excess Risk of Dying From Infectious Causes in Those With Type 1 and Type 2 Diabetes

et al. 2015

View full text Add to dashboard Cite

OBJECTIVETo investigate infection-related mortality in individuals with type 1 and type 2 diabetes. RESEARCH DESIGN AND METHODSA total of 1,108,982 individuals with diabetes who were registered with the Australian Diabetes register between 2000 and 2010 were linked to the National Death Index. Mortality outcomes were defined as infection-related A-B death (ICD codes A99-B99), pneumonia (J12-J189), septicemia (A40 and A41), and osteomyelitis (M86). RESULTSDuring a median follow-up of 6.7 years, there were 2,891, 2,158, 1,248, and 147 deaths from infection-related A-B causes, pneumonia, septicemia, or osteomyelitis, respectively. Crude mortality rates from infections A-B were 0.147 and 0.431 per 1,000 person-years in type 1 and type 2 diabetes, respectively. Standardized mortality ratios (SMRs) were higher in type 1 and type 2 diabetes for all outcomes after adjustment for age and sex. For infection-related A-B mortality, SMRs were 4.42 (95% CI 3.68-5.34) and 1.47 (1.42-1.53) for type 1 and type 2 diabetes (P < 0.001), respectively. For pneumonia in type 1 diabetes, SMRs were approximately 5 and 6 in males and females, respectively, while the excess risk was ∼20% for type 2 (both sexes). For septicemia, SMRs were approximately 10 and 2 for type 1 and type 2 diabetes, respectively, and similar by sex. For osteomyelitis in type 1 diabetes, SMRs were 16 and 58 in males and females, respectively, and ∼3 for type 2 diabetes (both sexes). CONCLUSIONSAlthough death owing to infection is rare, we confirm that patients with diabetes have an increased mortality from a range of infections, compared with the general population, and that the increased risk appears to be greater for type 1 than type 2 diabetes.Individuals with type 1 and type 2 diabetes are widely considered to be more prone to infections than those without diabetes (1). Evidence to support this hypothesis can be traced back as far as 1915 when Lichty noted a range of acute infections in patients with diabetes who subsequently died (2). Several decades later, two wellcited studies showed that bacteremia and bacteriuria are more common in adult women with diabetes versus those without (1,3). The factors thought to explain the excess risk of infections in these women were microvascular complications such as

show abstract

mentioning

confidence: 99%

Excess Risk of Dying From Infectious Causes in Those With Type 1 and Type 2 Diabetes

et al. 2015

View full text Add to dashboard Cite

show abstract

“…U populacijama sa češćom pojavom tuberkuloze rizik za tuberkulozu je veći kod bolesnika sa dijabetesom koji su na insulinskoj terapiji naročito kod onih koji su na visokim dozama insulina. Za razliku od prethodnog, u populacijama sa niskom incidencom za tuberkulozu kao što je Australija, rizik za pojavu tuberkuloze kod bolesnika sa dijabetesom nije povećan [8]. Studije koje su se bavile učestalošću tuberkuloze u odnosu na pol, dale su oprečne rezultate [9], a u našoj studiji, iako je postojala razlika u odnosu muš-karaca i žena u dvije ispitivane grupe, ona nije bila statistički značajna.…”

Section: Diskusijaunclassified

Poređenje karakteristika plućne tuberkuloze kod bolesnika sa i bez dijabetesa

Petrović¹,

Stojanović²,

Mavija

et al. 2017

Biomedicinska istraž.

View full text Add to dashboard Cite

Kratak sadržajUvod. U svijetu se bilježi globalni porast oboljelih od tuberkuloze i dijabetesa. Bolesnici sa dijabetesom imaju dvostruko veći rizik oboljevanja od aktivne tuberkuloze, četiri puta veći rizik od recidiva tuberkuloze i dva puta veći rizik od smrti tokom liječenja tuberkuloze. Cilj rada je utvrditi učestalost atipične radiološke lokalizacije tuberkuloze i učestalost komorbiditeta, kao i potrebu za promjenom liječenja dijabetesa kod bolesnika sa tuberkulozom i dijabetesom u odnosu na bolesnike bez dijabetesa.Metode. Ispitivane su dvije grupe bolesnika: grupu 1 činilo je trideset bolesnika sa tuberkulozom i dijabetesom, a grupu 2 trideset bolesnika sa tuberkulozom bez dijabetesa. Retrospektivnom analizom medicinske dokumentacije bolesnika utvrđena je radiografska lokalizacija promjena na plućima, terapija dijabetesa, komorbiditeti i ishod liječenja.Rezultati. U grupi 1 na radiografiji pluća tipičnu rediografsku sliku i lokaliza ciju plućne tuberkuloze je imalo 30%, a atipičnu lokalizaciju 70% bolesnika, dok je u grupi 2 tipična lokalizacija utvrđena kod 33,3%, a atipična kod 66,7% bolesnika (p = 0,781). Prije prijema u bolnicu 60% bolesnika grupe 1 je liječeno oralnim antidijabeticima, 13,3% insulinom, a 26,7% dijetom. Poslije otpusta, oralnim antidijabeticima je liječeno 53,3% bolesnika, 36,7% insulinom, 10% dijetom. Najčešći komorbiditeti u grupi 1 bile su kardiovaskularne bolesti (56,6%) i hronična opstruktivna bolest pluća (30,0%), a u grupi 2 kardiovaskularne bolesti (33,3%), dok su hronična opstruktivna bolest pluća i anemija bile zastupljene u istom procentu od 16,6%. Ishod liječenja bolesnika dvije ispitivane grupe značajno se razlikovao. U grupi 1 izliječena su 24 bolesnika, a 6 bolesnika je umrlo, dok je u grupi 2 izliječeno 29, a umro 1 bolesnik (p = 0,044).Zaključak. Nije utvrđena značajna razlika u učestalosti atipične radiološke lokalizacije tuberkuloze ni u učestalosti komorbiditeta kod bolesnika sa dijabetesom i onih bez dijabetesa. Bolesnici sa dijabetesom zahtijevali su tokom liječenja tuberkuloze korekciju liječenja dijabetesa. Utvrđen je statistički značajno veći broj umrlih bolesnika u grupi sa tuberkulozom i dijabetesom u odnosu na onu bez dijabetesa.

show abstract

“…In Zambia, another country with a very high TB burden (462/100,000 population), it was found that TB comorbidity was significantly associated with DM (OR = 6.5, 95% CI 1.7-25.3) 13,14 . Conversingly, in countries with a low TB burden such as Australia (5.8/100,000), TB risk in diabetic patients was increased only moderately (adjusted relative risk RR = 1.48, 95% CI 1.04-2.10) 15 . In a cohort study from Hong Kong, patients with well-controlled DM had lower risk for TB 16 .…”

Section: Epidemiologymentioning

confidence: 99%

‘Diabetes and Tuberculosis’ – A Co-Epidemic of Public Health Importance in the Developing World

Kumpatla¹,

Viswanathan²

2017

Current Science

View full text Add to dashboard Cite

With the rising epidemic of diabetes mellitus (DM) and tuberculosis (TB) already being a major infectious disease of the world, when put together, this coepidemic constitutes a threat to global public health. The situation is critical in countries like India which are facing the dual burden of non-communicable diseases and communicable diseases. This not only affects the national productivity, but also the national exchequer. Henceforth, a crucial health strategy is required to control this co-epidemic. This article reviews the epidemiology of DM and TB, TB and its characteristics, the effect of DM on TB treatment outcomes, screening methods and diagnosis, economic impact on the health sector and guidelines which could prevent this burden.

show abstract

Risk of tuberculosis among people with diabetes mellitus: an Australian nationwide cohort study

Cited by 82 publications

References 18 publications

Excess Risk of Dying From Infectious Causes in Those With Type 1 and Type 2 Diabetes

Excess Risk of Dying From Infectious Causes in Those With Type 1 and Type 2 Diabetes

Poređenje karakteristika plućne tuberkuloze kod bolesnika sa i bez dijabetesa

‘Diabetes and Tuberculosis’ – A Co-Epidemic of Public Health Importance in the Developing World

Contact Info

Product

Resources

About