Risk of skin cancer in patients with HIV: A Danish nationwide cohort study

Omland, Silje Haukali; Ahlström, Magnus Glindvad; Gerstoft, Jan; Pedersen, Gert Frølund; Mohey, Rajesh; Pedersen, Court; Kronborg, Gitte; Larsen, Carsten Schade; Kvinesdal, Birgit; Gniadecki, Robert; Obel, Niels; Omland, Lars Haukali

doi:10.1016/j.jaad.2018.03.024

Cited by 61 publications

(39 citation statements)

References 16 publications

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“…An equivalent study in Denmark revealed a five-fold increase in SCC rate and a 1.8-fold increase in BCC in HIV-positive patients [39]. Recent reports investigating the risk of CM in White HIV-positive patients in North America [40] and Denmark [39] found no difference compared with the general population. As is the case for CM in immunocompetent individuals, older age and higher sun exposure were associated with an increased risk [40].…”

Section: Risk Factors For the Development Of Skin Cancer In Southern mentioning

confidence: 97%

“…Studies in California demonstrated that there was a greater than two-fold higher incidence of SCC, but not of BCC, in White HIV-positive patients compared with White HIV-negative controls [37,38]. An equivalent study in Denmark revealed a five-fold increase in SCC rate and a 1.8-fold increase in BCC in HIV-positive patients [39]. Recent reports investigating the risk of CM in White HIV-positive patients in North America [40] and Denmark [39] found no difference compared with the general population.…”

Section: Risk Factors For the Development Of Skin Cancer In Southern mentioning

confidence: 98%

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The Epidemiology of Skin Cancer and Public Health Strategies for Its Prevention in Southern Africa

Wright

Preez

Millar

et al. 2020

IJERPH

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Skin cancer is a non-communicable disease that has been underexplored in Africa, including Southern Africa. Exposure to solar ultraviolet radiation (UVR) is an important, potentially modifiable risk factor for skin cancer. The countries which comprise Southern Africa are Botswana, Lesotho, Namibia, South Africa, and Swaziland. They differ in population size and composition and experience different levels of solar UVR. Here, the epidemiology and prevalence of skin cancer in Southern African countries are outlined. Information is provided on skin cancer prevention campaigns in these countries, and evidence sought to support recommendations for skin cancer prevention, especially for people with fair skin, or oculocutaneous albinism or HIV-AIDS who are at the greatest risk. Consideration is given to the possible impacts of climate change on skin cancer in Southern Africa and the need for adaptation and human behavioural change is emphasized.

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Section: Risk Factors For the Development Of Skin Cancer In Southern mentioning

confidence: 97%

Section: Risk Factors For the Development Of Skin Cancer In Southern mentioning

confidence: 98%

The Epidemiology of Skin Cancer and Public Health Strategies for Its Prevention in Southern Africa

Wright

Preez

Millar

et al. 2020

IJERPH

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“…e Odds Ratio for PLHIV to develop KS in SA was reported as 134 [18]. PLHIV are also at higher risk for developing NMSC with a 5-fold increased risk of SCC [18,19]. is may also explain the lower BCC to SCC ratio as mentioned.…”

Section: Discussionmentioning

confidence: 97%

“…Despite the rollout of the antiretroviral therapy (ART) programme in South Africa in 2004 the risk of KS amongst PLHIV remains elevated even in the ART era [18]. Omland et al also observed a 2-fold increased risk of BCC and a 5-fold increased risk of SCC in PLHIV compared with the background population [19]. e increasing incidence of skin cancers places major financial strain on South Africa's already overburdened public healthcare system.…”

Section: Introductionmentioning

confidence: 99%

An Analysis of Biopsies for Suspected Skin Cancer at a Tertiary Care Dermatology Clinic in the Western Cape Province of South Africa

Wet

Steyn

Jordaan

et al. 2020

Journal of Skin Cancer

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Background. Skin cancer is a growing health concern worldwide. It is the most common malignancy in South Africa and places a large burden on the public healthcare sector. There is a paucity of published scientific data on skin cancer in South Africa. Objectives. To report the findings of biopsies performed in patients with suspected skin cancer attending the Tygerberg Academic Hospital (TAH) Dermatology outpatient department (OPD) in the Western Cape Province of South Africa. Methodology: A retrospective chart review identified all patients who underwent a biopsy for a suspected skin cancer diagnosis between September 2015 and August 2016 at the TAH dermatology OPD. Results. A total number of 696 biopsies from 390 participants were identified, of which 460 were histologically confirmed as malignant lesions. The proportion of clinically suspected skin cancers that were histologically confirmed as cancer was 68%. The most commonly occurring malignancies were basal cell carcinoma (BCC) (54.8%), squamous cell carcinoma (SCC) (18.9%), squamous cell carcinoma in-situ (SCCI) (8.0%), Kaposi’s sarcoma (KS) (6.7%), malignant melanoma (MM) (6.1%), and keratoacanthoma (KA) (4.6%). The number needed to treat (NTT) for all cancers diagnosed and for MM was 1.5 and 4 respectively. BCC (89.3%) and KS (67.7%) was the most common skin cancer in the white and black population respectively. The ratio of BCC to SCC was 2.03. Conclusion. This study provides valuable scientific data on the accuracy of skin cancer diagnosis, distribution and patient demographics in the Western Cape Province of South Africa, on which further research can be based. The study highlights the burden of skin cancer on this specific population group and calls for standardised reporting methods and increased surveillance of skin cancers.

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“…Bazı enfeksiyonların da deri kanseri açısından risk oluşturduğu bilinmektedir. HIV pozitif bireylerde BHK riski yaklaşık 2 kat, SHK riski yaklaşık 5 kat artmış olarak bulunmuştur (Omland et al, 2018). Chen ve ark.…”

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Epigenetic and Environmental Risk Factors in Skin Cancer

2020

JSTR

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Epigenetic mechanisms cause changes in gene expression and cell phenotype without DNA sequence changes. They have been reported to play role in skin cancers, and identified as DNA methylation, histone modifications and microRNAs. Skin cancer is one of the most common types of cancer in humans and squamous cell carcinoma, basal cell carcinoma, and melanoma are three main types. There are many environmental risk factors for skin cancer such as ultraviolet radiation, ionizing radiation, viruses. Chronic ultraviolet exposure is accepted as the most important one. Environmental factors including ultraviolet radiation have also been reported to cause epigenetic modifications. This review will introduce the role of epigenetic in skin cancer, environmental risk factors in skin cancer and epigenetic modifications caused by these environmental risk factors.

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Risk of skin cancer in patients with HIV: A Danish nationwide cohort study

Abstract: Patients with HIV have an increased risk of BCC and SCC. Low nadir, but not current, CD4 cell count as a marker of immunosuppression was associated with an increased risk of SCC.

Cited by 61 publications

References 16 publications

The Epidemiology of Skin Cancer and Public Health Strategies for Its Prevention in Southern Africa

The Epidemiology of Skin Cancer and Public Health Strategies for Its Prevention in Southern Africa

An Analysis of Biopsies for Suspected Skin Cancer at a Tertiary Care Dermatology Clinic in the Western Cape Province of South Africa

Epigenetic and Environmental Risk Factors in Skin Cancer

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