Risk of retinopathy of prematurity in small for gestational age premature infants

Kavurt, Sumru; Özcan, Beyza; Aydemir, Özge; Baş, Ahmet Yağmur; Demirel, Nihal

doi:10.1007/s13312-014-0506-9

Cited by 24 publications

(27 citation statements)

References 16 publications

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“…12 Our findings were in agreement with the studies of Mehmet et al 13 Maternal diabetes and ROP was also not significantly linked in this study. This is in agreement with the studies of Kavurt et al 14 Our study also did not find any link between ROP and maternal infertility treatment. This was in contrast with the study by Paul-Chan RV et al, 15 which linked assisted reproduction to retinopathy of prematurity.…”

Section: Risk Factorssupporting

confidence: 94%

Retinopathy of Prematurity- A Clinical Study

Padmavathi¹,

Vaikkakara²,

Mohammed³

2017

jebmh

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BACKGROUND The aim of the study is to detect the incidence of retinopathy of prematurity among low birth weight and preterm infants and identification of potential risk factors for retinopathy of prematurity. MATERIALS AND METHODS It was a prospective cohort study enrolling all neonates who presented for retinopathy of prematurity screening with birth weight ≤1750 g and/or neonates born at less than 34 weeks gestational age and neonates with gestational age between 34 to 37 weeks gestational age or a birth weight between 1750 and 2000 g, if high-risk factors like history of prolonged oxygen therapy, mechanical ventilation and haemodynamic instability is present. A total of 100 infants had retinal evaluation by indirect ophthalmoscopy and were followed up periodically. Prenatal and postnatal risk factors for ROP were assessed. RESULTS Out of the 100 infants screened, 37 had ROP. Of the 74 eyes screened, stage 1 was seen in 41 eyes, stage 2 in 19 eyes and stage 3 in 14 eyes. Zone 1 disease was seen in 10 eyes, zone 2 in 24 eyes and zone 3 in 40 eyes plus disease was seen in 10 infants. Lower birth weight (P<0.001), lower gestational age (P<0.001), oxygen therapy, (P=0.001), respiratory distress syndrome (P<0.001), multiple gestation (P<0.001) long length of ICU stay (P<0.001) were significant risk factors in this study. No significant association was detected between maternal age, diabetes, hypertension, treatment for infertility, mode of delivery, sex of infant, mechanical ventilation, 1 minute Apgar score, phototherapy, sepsis and PDA. CONCLUSION The incidence of ROP is 37%. Lower birth weight, prematurity, compromised pulmonary function, multiple gestation, long length of ICU stay were significant risk factors in this study.

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Section: Risk Factorssupporting

confidence: 94%

Retinopathy of Prematurity- A Clinical Study

Padmavathi¹,

Vaikkakara²,

Mohammed³

2017

jebmh

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“…The role of SGA in the development of ROP is controversial. Studies have shown that SGA infants are at increased risk of ROP, and presence of SGA is an independent predictor for ROP 5–7. Contrarily, studies have also demonstrated that SGA is not a significant risk factor for ROP 8–10.…”

Section: Introductionmentioning

confidence: 99%

Association of small for gestational age with retinopathy of prematurity: a systematic review and meta-analysis

Razak

Faden

2019

Arch Dis Child Fetal Neonatal Ed

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ContextThe association between small for gestational age (SGA) and retinopathy of prematurity (ROP) is unclear.ObjectiveA systematic review and meta-analysis was conducted to evaluate the association between ROP and SGA in preterm infants <37 weeks’ gestational age (GA) admitted to neonatal intensive care unit.MethodsMedline, PubMed, Web of Science and Cochrane Central databases were searched from inception through 15 January 2019. Studies reporting outcomes based on SGA as the primary exposure variable were included. Data were extracted independently by two coauthors. Modified Newcastle-Ottawa scale was used for risk of bias assessment.ResultsDatabase search yielded 536 records (Medline=152, PubMed=171, Web of Science=144 and Cochrane Central=69). Twenty-one studies evaluating 190 946 infants were included. SGA was associated with significantly higher odds of any stage of ROP on unadjusted analysis (unadjusted OR (uOR) 1.55; 95% CI 1.22 to 1.98; 10 studies) but not on adjusted analysis (adjusted OR (aOR) 2.16; 95% CI 0.66 to 7.11; 3 studies). SGA was associated with significantly higher odds of severe ROP (aOR 1.92; 95% CI 1.57 to 2.34; nine studies). SGA was also significantly associated with higher odds of treated ROP (aOR 1.39; 95% CI 1.18 to 1.65; three studies). In subgroup analysis of infants <29 weeks’ GA, SGA was significantly associated with increased odds of ROP (uOR 1.64; 95% CI 1.19 to 2.26; two studies), severe ROP (aOR 1.61; 95% CI 1.23 to 2.10; four studies) and treated ROP (aOR 1.37; 95% CI 1.16 to 1.62; two studies).ConclusionSGA was associated with increased odds of any stage of ROP, severe ROP and treated ROP in preterm infants. Neonatologists should incorporate SGA into the risk assessment during ROP evaluation and while providing counselling to the families of preterm SGA infants. ROP screening guidelines should look into the frequency of follow-up examination in SGA infants in aim to offer early detection and treatment.

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“…Holmstrom G et al found in their study by multiple regression analysis, apart from gestational age and birth weight, only essential hypertension prior to pregnancy was a predicting risk factor. 10,13,37 Sood V et al, found PIH to be a significant risk factor (p=0.006) for development of ROP. 12 However, in this study 8 out of 41 babies (19.59%) with maternal history of PIH developed ROP.…”

Section: Discussionmentioning

confidence: 99%

A clinical study on retinopathy of prematurity in a tertiary care centre

Dalai¹,

Das²,

Nayak³

et al. 2019

Int J Res Med Sci

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Background: Retinopathy of prematurity (ROP) is a multifactorial vasoproliferative retinal disorder that increases in incidence with decreasing gestational age. India shares 20% of the world childhood blindness. Besides congenital cataract, congenital glaucoma and ocular injuries, ROP is emerging as one of the important causes of childhood blindness in India.Methods: This hospital based prospective study was undertaken during October 2016 to September 2018 in the Department of Ophthalmology, SCB Medical College. Authors included (a) all preterm infants weighing less than 1750gm or gestational age less than 34 weeks at birth, (b) infants with birth weight between 1750gm to 2000gm and gestational age more than 34 weeks (late preterm and term infants) those were considered as high risk.Results: Among the 328 babies included in our study, the incidence of ROP was 29.57%. Bilateral ROP was found in 76.29% with nearly equal stages in both eyes and only 23 neonates showed unilateral involvement.Conclusions: Low birth weight, lower gestational age, blood transfusion, Respiratory Distress Syndrome (RDS), apnoea, supplemental oxygen therapy, maternal anaemia and gestational diabetes mellitus (GDM) were strongly associated with development of ROP.

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Risk of retinopathy of prematurity in small for gestational age premature infants

Abstract: Clinicians should be aware of the presence of presence of retinopathy of prematurity when caring for protein small for gestational age infants.

Cited by 24 publications

References 16 publications

Retinopathy of Prematurity- A Clinical Study

Retinopathy of Prematurity- A Clinical Study

Association of small for gestational age with retinopathy of prematurity: a systematic review and meta-analysis

A clinical study on retinopathy of prematurity in a tertiary care centre

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