Risk of Recurrence in Differentiated Thyroid Cancer: A Population-Based Comparison of the 7th and 8th Editions of the American Joint Committee on Cancer Staging Systems

Gan, Tong J.; Huang, Bin; Chen, Quan; Sinner, Heather F.; Lee, Cortney Y.; Sloan, David A.; Randle, Reese W.

doi:10.1245/s10434-019-07275-1

Cited by 20 publications

(12 citation statements)

References 26 publications

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“…to the lower stages with the change in age cutoff was expected to be small [4][5][6]. However, patients with lateral neck lymph metastasis (N1b) belong to stage IVA by the AJCC-7 classification, and it is unclear how T4 disease influenced prognosis based on AJCC-8 with the change in age cutoff.…”

Section: Discussionmentioning

confidence: 99%

Impact of gross extrathyroidal extension into major neck structures on the prognosis of papillary thyroid carcinoma according to the American Joint Committee on Cancer eighth edition

Moritani¹

2020

Endocr J

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This study investigated the impact of gross extrathyroidal extension into major neck structures on the prognosis of papillary thyroid carcinoma according to changes in the American Joint Committee on Cancer (AJCC)/Tumor-Node-Metastasis staging system. Overall, 183 patients with gross extrathyroidal extension into major neck structures were enrolled. The 10-year disease-specific survival (DSS) of patients in each stage showed appropriate correlation and stratification with the AJCC eighth edition. However, the 10-year DSS rate in stage III was better than the expected 10-year DSS rate, according to the AJCC eighth edition. Patients in stage III were subcategorized into three new groups: stage IIIA, patients with only recurrent laryngeal nerve invasion; stage IIIB, patients with superficial invasion of the aerodigestive tract; and stage IIIC, patients with intraluminal invasion of the aerodigestive tract. The prognostic differences among these three groups and stage IVA were examined. Although the DSS rate of patients in stage IIIA was excellent, that of patients with T4a disease was worse due to the progression of aerodigestive tract infiltration. Of the four groups, the time to locoregional recurrence was the shortest for patients in stage IVA. The distant recurrent-free survival for patients in stages IIIC and IVA tended to be worse than those for patients in stages IIIA and IIIB. These results indicate that the progression of aerodigestive tract infiltration has an impact on the incidence of distant recurrence, and the presence of T4b disease has an impact on the incidence of distant and locoregional recurrences.

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Section: Discussionmentioning

confidence: 99%

Impact of gross extrathyroidal extension into major neck structures on the prognosis of papillary thyroid carcinoma according to the American Joint Committee on Cancer eighth edition

Moritani¹

2020

Endocr J

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“…In our patient cohort, recurrence rates were relatively high reaching 29%, 43%, and 68% for patients initially diagnosed in Stage I, Stage II, and Stage III; respectively (Table 2 ). Gan et al [ 18 ] reported a recurrence rate of 3% among patients with differentiated thyroid cancers after a median follow-up of 27 months. A recent study found significantly different recurrence rates in patients diagnosed in early and advance stages (7.2% vs 28.2%) [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Extrathyroidal extension and cervical node infiltration are associated with recurrences and shorter recurrence-free survival in differentiated thyroid cancer: a cohort study

et al. 2022

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Background Differentiated thyroid cancer has excellent overall survival. However, around 20% of patients experience recurrent diseases after a certain time of follow-up. Therefore, identification of risk factors for recurrence is necessary to adjust treatment and surveillance planning. Methods A retrospective study was conducted of 312 patients with differentiated thyroid cancer who received surgery with and without adjuvant treatment. Clinical and pathological risk factors were analyzed for recurrences. Results After median follow-up of 57 months, 109 of 312 patients (34.9%) developed recurrences. Extrathyroidal extension and positive cervical nodes were significantly associated with recurrences (OR = 2.449, 95%CI:1.260–4.760, P = 0.008 and OR = 3.511, 95%CI:1.860–6.626, P < 0.001; respectively). Lympho-vascular invasion (LVI) and tumor multifocality were also associated with increased risk of recurrence (OR = 2.577, 95%CI:1.380–4.812, P = 0.003 and OR = 1.602, 95%CI:1.001–2.495, P = 0.050; respectively). Using multivariable regression, only older age and tumor infiltration to the lymph nodes were significantly associated with recurrences (OR = 2.227, 95%CI:1.037–4.782, P = 0.040 and OR = 2.966, 95%CI:1.470–5.986, P = 0.002; respectively). In addition, T4, cervical lymph node infiltration, older age, and LVI were associated with shorter recurrence-free survival. Conclusion Recurrence rates in our study population are relatively high. Extrathyroidal extension, positive neck lymph node, and older age were associated with recurrence risks of well differentiated thyroid cancers.

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“…As regards to staging and risk prediction, in line with others, we undertook AJCC staging system and ATA stratification prediction system as they are the best predictors of mortality and recurrence respectively [ 23 ]. We also employed the AJCC 8th edition that better differentiates differentiated thyroid carcinoma (DTC) risk recurrence for early stages of disease compared with the 7th edition [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Simultaneous occurrence of follicular and papillary thyroid carcinomas in same thyroid lobe: A case series of six patients from Qatar

Abdelaal

Ansari

Abusabeib

et al. 2020

International Journal of Surgery Case Reports

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Highlights Simultaneous occurrence of papillary and follicular thyroid carcinomas in the same lobe are very rare. First case series of simultaneous occurrence of these two types of thyroid cancer in the Middle East and North Africa Region. Endocrinologists and pathologists should be aware of and vigilant to this variety. Occurrence of both types together shifts patients from low risk to intermediate or high risk which may reflect on management.

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Risk of Recurrence in Differentiated Thyroid Cancer: A Population-Based Comparison of the 7th and 8th Editions of the American Joint Committee on Cancer Staging Systems

Cited by 20 publications

References 26 publications

Impact of gross extrathyroidal extension into major neck structures on the prognosis of papillary thyroid carcinoma according to the American Joint Committee on Cancer eighth edition

Impact of gross extrathyroidal extension into major neck structures on the prognosis of papillary thyroid carcinoma according to the American Joint Committee on Cancer eighth edition

Extrathyroidal extension and cervical node infiltration are associated with recurrences and shorter recurrence-free survival in differentiated thyroid cancer: a cohort study

Simultaneous occurrence of follicular and papillary thyroid carcinomas in same thyroid lobe: A case series of six patients from Qatar

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