Simultaneous occurrence of follicular and papillary thyroid carcinomas in same thyroid lobe: A case series of six patients from Qatar

Abdelaal, Abdelrahman; Ansari, Walid El; Abusabeib, Abdelrahman; Farghaly, Hanan; Tabeb, Abdelhakem

doi:10.1016/j.ijscr.2020.06.070

Cited by 12 publications

(20 citation statements)

References 26 publications

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“…A series composed of six cases of follicular and papillary collision tumors was reported in 2020 and this was the first series of these rare collision tumors [15].…”

Section: Discussionmentioning

confidence: 99%

Collision tumor of the thyroid gland: Follicular carcinoma and papillary microcarcinoma

et al. 2022

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Collision tumor represents the proximal coexistence of two histologically distinct tumors. The combination of two different types of tumors in a single thyroid gland is extremely unusual. We reported a case of follicular carcinoma and papillary microcarcinoma occur independently as a primary tumor separated by a normal tissue in a 59-yearold Saudi female, presented at the clinic with goiter for two months duration without symptoms of thyroid hormonal disorders. This case is one of few cases to be reported as a combined follicular thyroid carcinoma and papillary thyroid carcinoma in English literature.

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“…A series composed of six cases of follicular and papillary collision tumors was reported in 2020 and this was the first series of these rare collision tumors [15].…”

Section: Discussionmentioning

confidence: 99%

Collision tumor of the thyroid gland: Follicular carcinoma and papillary microcarcinoma

et al. 2022

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“…Despite the rst reporting of a collision tumour of PTC and FTC almost a decade ago by Plauche et.al, data on this phenomenon is still lacking. [4,5,7].…”

Section: Discussionmentioning

confidence: 99%

“…A number of theories have been proposed concerning the pathogenesis of these tumours but none could completely explain this phenomenon. In their retrospective review of 53 patients, Kim et al proposed that concurrent occurrences of thyroid carcinomas could simply be coincidental but did recognize the various theories related to this event which includes -stem cell theory, collision theory, hostage theory, tumourigenic stimulus and divergent differentiation theory [7,[23][24][25][26]. Genetic mutations were detected in studies of collision tumours and several genes have been implicated, namely BRAF, RAS and RET protooncogenes [27][28][29].…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of this entity is poorly established owing to its rarity and scarcity of available literature -mainly in the form of case reports. [3][4][5][6][7][8]. Herein, we report a case of collision tumour of PTC and FTC in the same anatomical lobe and PTC in the opposite lobe in a patient with a background of Hashimoto's thyroiditis.…”

Section: Introductionmentioning

confidence: 99%

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Rare Collision Tumour of Papillary and Follicular Thyroid Carcinoma: A Case Report

Mothayapan

Ong

2022

Preprint

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BackgroundPapillary thyroid carcinomas and follicular thyroid carcinomas account for 90 - 95% of all thyroid cancers. Both have distinct features which are best evaluated histologically. The co-existence of these two cancers is extremely rare and have only been described in case reports. We report a rare case of a collision tumour of papillary and follicular thyroid carcinomas in the same anatomical thyroid gland. Case PresentationA 43-year-old woman was referred to the endocrine surgery clinic for an anterior neck mass found on routine check-up. A right thyroid nodule was clinically palpable. Thyroid function tests were normal. An ultrasound scan revealed bilateral thyroid nodules which warranted fine needle aspiration. Fine needle aspiration of the right nodule was consistent with cyst content, which was non-diagnostic while fine needle aspiration of the left nodule demonstrated atypia of undetermined significance. The patient was counselled for a left hemithyroidectomy but opted instead for removal of the enlarged right thyroid nodule. A right hemithyroidectomy was performed and histopathological examination revealed follicular carcinoma with capsular and vascular invasion as well as a nodule consisting of papillary carcinoma. These two malignant nodules were separated by a section of normal thyroid tissue hence this was termed as a “collision tumour”. A completion left hemithyroidectomy revealed papillary carcinoma in the left thyroid lobe. Post-surgery, the patient was treated with radioiodine (131I) and thyroxine suppression therapy. ConclusionCollision tumours have been described as two independent tumours with distinct morphology which occur concurrently at the same site but having a distinct border. They are extremely rare entities with only a handful of cases reported so far, thus posing a diagnostic challenge to the unwary clinician. The concept of triple assessment by clinical, radiological and cyto-histopathological correlation is fundamental in investigating thyroid nodules but may miss a collision tumour. A number of theories and genetic mutations have been implicated in this collision phenomenon, but none have been proven so far. Collision tumours are not fully understood and their unpredictable biological behaviour render management decisions on treatment difficult. An individualized patient-approach in a multidisciplinary setting should be adopted to improve patient outcomes.

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“…The incidence rate of PTC is about 0.5-10 per 100,000 populations worldwide [19]. It is well known that most PTC patients have relatively good prognosis.…”

Section: Discussionmentioning

confidence: 99%

TROP2 modulates the progression in papillary thyroid carcinoma

et al. 2021

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Background: Tumor-associated calcium signal transducer 2 (TROP2) is over expressed in various kinds of human cancers and plays important roles in the proliferation, invasion and metastasis of tumor cells. However, the expression and molecular mechanism of TROP2 in thyroid papillary carcinoma (PTC) are unclear. Methods: The expressions of TROP2 in PTC and control tissue were detected by real-time reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry. The proliferation and invasion of PTC cell lines were examined by cell cloning and transwell assays. RNA sequencing analysis and public data analysis were assessed to investigate the potential mechanisms of TROP2 in PTC. Gene correlation analysis was conducted to explore the association between TROP2 and the related gene ISG15 in patients with PTC. Results: The expression of TROP2 was significantly higher in PTC than control. The high expression of TROP2 protein was associated with lymph node metastasis, tumor size and capsular infiltration (P<0.05). SiRNA-mediated TROP2 gene expression silencing can significantly inhibit proliferation and migration of PTC cells. ISG15 decreased in TROP2 siRNA PTC cells and increased in PTC patients significantly. There was a significant correlation between the expression of TROP2 and ISG15 in PTC patients. TROP2 interacted directly with ATP6V1A, CEBPA and SOX5 and then further interacted with the immune genes. TROP2 expression and tumor-infiltrating immune cells were also correlated in thyroid cancer microenvironment. Conclusions: TROP2 promotes the development of PTC. TROP2 expression was correlated with ISG15 and tumor-infiltrating immune cells in thyroid cancer.

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Simultaneous occurrence of follicular and papillary thyroid carcinomas in same thyroid lobe: A case series of six patients from Qatar

Cited by 12 publications

References 26 publications

Collision tumor of the thyroid gland: Follicular carcinoma and papillary microcarcinoma

Collision tumor of the thyroid gland: Follicular carcinoma and papillary microcarcinoma

Rare Collision Tumour of Papillary and Follicular Thyroid Carcinoma: A Case Report

TROP2 modulates the progression in papillary thyroid carcinoma

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