Risk of optic neuritis in type 2 diabetes mellitus: A nationwide cohort study

Lee, Ga-In; Han, Kyungdo; Park, Kyung-Ah; Oh, Sei Yeul

doi:10.1016/j.jns.2023.120673

Cited by 1 publication

(1 citation statement)

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“…This finding is consistent with prior research. A cohort study found optic neuritis intensifies with the duration of diabetes and increasing glucose levels (28). This finding aligns with our research.…”

Section: Disorders Of Optic Nerve and Visual Pathwayssupporting

confidence: 93%

Dissecting causal associations of type 2 diabetes with 111 types of ocular conditions: a Mendelian randomization study

Chen,

Xu,

Ding

et al. 2023

Front. Endocrinol.

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BackgroundDespite the well-established findings of a higher incidence of retina-related eye diseases in patients with diabetes, there is less investigation into the causal relationship between diabetes and non-retinal eye conditions, such as age-related cataracts and glaucoma.MethodsWe performed Mendelian randomization (MR) analysis to examine the causal relationship between type 2 diabetes mellitus (T2DM) and 111 ocular diseases. We employed a set of 184 single nucleotide polymorphisms (SNPs) that reached genome-wide significance as instrumental variables (IVs). The primary analysis utilized the inverse variance-weighted (IVW) method, with MR-Egger and weighted median (WM) methods serving as supplementary analyses.ResultsThe results revealed suggestive positive causal relationships between T2DM and various ocular conditions, including “Senile cataract” (OR= 1.07; 95% CI: 1.03, 1.11; P=7.77×10-4), “Glaucoma” (OR= 1.08; 95% CI: 1.02, 1.13; P=4.81×10-3), and “Disorders of optic nerve and visual pathways” (OR= 1.10; 95% CI: 0.99, 1.23; P=7.01×10-2).ConclusionOur evidence supports a causal relationship between T2DM and specific ocular disorders. This provides a basis for further research on the importance of T2DM management and prevention strategies in maintaining ocular health.

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Section: Disorders Of Optic Nerve and Visual Pathwayssupporting

confidence: 93%