Risk of Obstructive Sleep Apnea and Echocardiographic Parameters

Abstract

Background: Obstructive sleep apnea (OSA) is a chronic progressive disorder with high mortality and morbidity rate, associated with cardiovascular diseases (CVD), especially heart failure (HF). The pathophysiological changes related to OSA can directly affect the diastolic function of the left ventricle. Objectives: To assess the association of the risk of OSA, evaluated by the Berlin Questionnaire (BQ), and echocardiographic (ECHO) parameters related to diastolic dysfunction in individuals without HF assisted in primary care. Methods: A cross-sectional study that included 354 individuals (51% women) aged 45 years or older. All individuals selected were submitted to an evaluation that included the following procedures: consultation, filling out the BQ, clinical examination, laboratory examination and transthoracic Doppler echocardiography (TDE). Continuous data are presented as medians and interquartile intervals, and categoric variables in absolute and relative frequencies. The variables associated with risk of OSA and at the 0.05 level integrated the gamma regression models with a log link function. A value of p < 0.05 was considered an indicator of statistical significance. Exclusion criteria were presence of HF, to fill out the BQ and patients with hypertension and obesity not classified as high risk for OSA by other criteria. All individuals were evaluated on a single day with the following procedures: medical appointment, BQ, laboratory tests and ECHO. Results: Of the 354 individuals assessed, 63% were classified as having high risk for OSA. The patients with high risk for OSA present significantly abnormal diastolic function parameters. High risk for OSA confirmed positive and statistically significant association, after adjustments, with indicators of diastolic function, such as indexed left atrium volume LAV-i (p = 0.02); E'/A' (p < 0.01), A (p = 0.02), E/A (p < 0.01). Conclusion: Our data show that patients at high risk for OSA present worsened diastolic function parameters measured by TDE.

Relação da apneia obstrutiva do sono com consumo de oxigênio, atividade fí­sica e alimentação

“…The low PAL observed in groups with OSA is mainly due to obesity and the low quality of sleep that causes daytime sleepiness [1,15]. It has also been described, in the literature, that individuals with reduced VO 2max tend to have less physical and functional capacity [1,3,17]. This will directly impact the ADLs of these individuals, as VO 2max is an indicator of cardiorespiratory resistance capacity and an important predictive parameter of morbidities associated with OSA, such as heart failure, stroke, among others that have been reported in similar studies [18].…”

“…Obstructive sleep apnea (OSA) is characterized by repeated upper airway obstructions [1,2]. This disorder is highly prevalent and has a considerable influence on the morbidity and mortality of the Brazilian population [2,3]. OSA may be associated with the development of type II diabetes mellitus [2].…”

“…OSA may be associated with the development of type II diabetes mellitus [2]. It is also a risk factor for systemic arterial hypertension, stroke, depression, insomnia, anxiety, and cardiovascular diseases [1,3]. Besides, it is known that the drowsiness characteristic of this disorder is the cause of many traffic and work accidents [1].…”

Obstructive Sleep Apnea and Cardiovascular Morbidities: A Review Article

“…A marker for diastolic dysfunction indexed left atrial volume (LAV-i) was significantly altered in OSA patients; these patients were asymptomatic without any symptoms or signs of heart failure (HF). Other changes included the E'/A' ratio (early diastolic mitral flow velocity), E', and A wave (A: atrial contraction) [ 25 ]. Patients with nocturnal oxygen saturation level (Spo 2 ) <92 independently correlated to E/A ratio, and they had an increased risk of experiencing left ventricular (LV) diastolic dysfunction by almost 2.76-fold.…”

Síndrome Da Abstinência Neonatal E Suas Consequencias Ao Recém-Nascido

“…Assim como na ocorrência diastólica(ZHAO et al, 2019). Em um estudo sobre a função diastólica em pacientes que não apresentavam insuficiência cardíaca, foi demonstrado que 63% dos pacientes possuíam alto risco para AOS e que estes apresentavam função diastólica significativamente anormal, explicitando que a AOS pode causar disfunções cardiovasculares pontuais e em diferentes graus(LEITE et al, 2019).• Aterosclerose e Doença arterial coronariana (DAC)A IH consiste na hipoxemia seguida por reoxigenação, situação que promove o desenvolvimento da lesão isquemia-reperfusão. Isso ocorre devido à produção exacerbada de espécies reativas de oxigênio (ERO's).…”