Risk of non-Hodgkin's lymphoma among men occupationally exposed to organic solvents.

Olsson, Håkan; Brandt, L.

doi:10.5271/sjweh.1925

Cited by 65 publications

(29 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The risk increase ratios vary between 0.9 and 4.7 (Hardell et al, 1981;Pearce et al, 1986, Woods et al, 1987Olsson et al, 1988;Kogevinas et al, 1995;Pahwa et al, 2012). The relationship between the use of pesticides and development of NHL has also been investigated in two cohort studies, which identified a borderline increase in risk (Kogevinas et al, 1997;Bertazzi et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin Lymphoma and Pesticide Exposure in Turkey

Yıldırım¹,

Karakilinc²,

Yıldız³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: Non-Hodgkin lymphoma (NHL) is a solid tumour of lymphocytes, important elements in the immune system. According to 2006 data, in Turkey the incidence was 6.5 per 100,000 in males, and 4.4 in females. The relationship between the use of pesticides and development of NHL has been extensively investigated in many studies, and it has been demonstrated that the risk of NHL is increased by exposure to such compounds. Antalya is a region of intensive agricultural activity. In this study, the relationship between the incidence of lymphoma in Antalya and the amount of pesticides employed was investigated. Materials and Methods: The study used data from 1995 to 2010 on the patients from the databank of TR Ministry of Health, Antalya Provincial Health Directorate, Cancer Registration Center and the patients who were histopathologically diagnosed with NHL during these years. Results: The relationship between the amount of pesticide used and the incidence was studied with the Spearman correlation analysis and the p value was found as 0.05. The correlation coefficient was 0.497. An increase in the NHL incidence over the years was identified, with a 2.42-fold increment found from 1995 to 2005 and a 2.77 fold elevation from 1995 to 2010. The use of pesticides increased 1.89 fold over the same period. Conclusions: Our study investigated the relationship of the pesticides used with NHL patients diagnosed during the same year. Since the time elapsing after exposure to pesticides until the development of cancer is not clear, no comparison can be made at present. We believe that the increase in use of pesticides since 1995 may be associated with the increase in the incidence of NHLand therefore that further studies on the issue including measurements of serum pesticide levels, are required.,

show abstract

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin Lymphoma and Pesticide Exposure in Turkey

Yıldırım¹,

Karakilinc²,

Yıldız³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…In addition, case-referent studies have suggested that occupational exposure to solvents might be a risk factor for non-Hodgkin's lymphoma (25,26). Exposure to ionizing radiation, especially radium, is the only well-established occupational agent related to bone cancer (27).…”

Section: Discussionmentioning

confidence: 99%

Cancer risk among workers in biomedical research

Cordier¹,

Mousel²,

Goaster³

et al. 1995

Scand J Work Environ Health

View full text Add to dashboard Cite

Objective This epidemiologic study was undertaken after a cluster of five cases of rare forms of cancer (bone sarcoma, non-Hodgkin's lymphoma) had been observed among biomedical research workers at the Pasteur Institute in Paris to ascertain whether their disease was connected with exposure during this research. Methods A mortality study included 3765 people who worked at the Pasteur Institute between 1971 and 1986 and were followed until the end of 1987. Within this cohort a nested case-referent study included 23 cases of cancer [non-Hodgkin's lymphoma (6), multiple myeloma (I), leukemia (3), pancreatic cancer (7), bone cancer (3), brain tumor (3)], and four referents per case, matched for gender and year of birth. Results Total mortality from cancer was less than expected, the standardized mortality ratio (SMR) being 72 for the men and 82 for the women. Among the women the proportion of pancreatic cancer cases was larger than expected [SMR 490, 95% confidence interval (95%CI) 158-1144], as was the number of brain cancer cases (SMR 239, 95% CI 48-696). Among the men, mortality from bone cancer was greater than expected (SMR 553,95% CI 62-2006). In the nested case-referent study, more cases than referents had worked in the areas of molecular biology [odds ratio (OR) 7.1, 95% CI 1.5-331 and microbial genetics (OR 6.7, 95% CI 1.3-35). These cases especially included non-Hodgkin's lymphoma and bone cancer. Associated with this finding was the fact that more cases had used certain chemicals, including ethidium bromide, acrylamide, methylnitronitrosoguanidine and ethylmethanesulfonate, and radioactive compounds (essentially 32phosphorus). C O~~C~U S~O~~S As the products used are potent genotoxicants, the present findings suggest that work in biomedical research might well involve an increased risk of certain types of cancer; this conclusion should be balanced by the fact that two of the five index cases were included in the mortality study and four in the nested casereferent study.

show abstract

“…[1][2][3] Although this remains mostly unexplained, it has been suggested that greater exposure to environmental carcinogens, particularly to pesticides and solvents, may be responsible. [4][5][6][7] Moreover, susceptibility to genomic damage has also been linked to dietary folate deficiency, because this metabolic pathway is important for both nucleotide synthesis and methylation. The genes encoding folate metabolic enzymes display several single nucleotide polymorphisms (SNPs)-for example, methylenetetrahydrofolate reductase (MTHFR C677T and MTHFR A1298C), serine hydroxymethyltransferase (SHMT C1420T), and methionine synthase (MS or MTR A2756G)-and variable number tandem repeats (VNTRs) for thymidylate synthase (TS or TYMS VNTR 2R and 3R).…”

Section: Introductionmentioning

confidence: 99%