Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas

Niclot, Sidonie; Pruvot, Quentin; Besson, Caroline; Savoy, D; Macintyre, Elisabeth; Salles, Gilles; Brousse, Nicole; Varet, Bruno; Landais, Paul; Taupin, Pierre; Junien, Claudine; Bluteau, Dominique

doi:10.1182/blood-2005-04-1567

Cited by 55 publications

(40 citation statements)

References 43 publications

(72 reference statements)

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“…MTHFR catalyzes irreversible reduction of 5,10-methylentetrahydrofolate to 5-methyltetrahydrofolate. The most significant polymorphic variants of the MTHFR gene are, probably, C677T and A1298C, which are suggested to modulate the risk to develop different multifactorial diseases including some cancers [14,15,34,35]. The MTRR enzyme participates in transferring of methyl group from 5-tetrahydrophosphate to homocysteine.…”

Section: Discussionmentioning

confidence: 99%

“…The MTRR enzyme participates in transferring of methyl group from 5-tetrahydrophosphate to homocysteine. The most significant and well-studied polymorphic variant of the MTRR gene is A66G, the change of A to G leads to decrease of catalytic activity of the enzyme, that in turn hampers homocysteine re-methylation and may cause different genetic defects [34,35].…”

Section: Discussionmentioning

confidence: 99%

“…Among potential biomarkers increasing NHL risk two susceptibility alleles in TNF and IL10 have been identified [13]. Several B-CLL and NHL studies have examined polymorphisms involved in folate metabolism; although, results have been inconsistent [14][15][16][17]. Among low-penetrance candidate genes, those involved in xenobiotic metabolism draw a special attention, because they may provide clues to identify potential lymphomagens and to estimate carcinogen effects of environmental pollution.…”

Section: Introductionmentioning

confidence: 99%

“…In this study the polymorphic alleles of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTRR) genes, involved in folate metabolism were added. Folate participates in DNA methylation and nucleotide synthesis, thus metabolic imbalance of this compound may have an impact to carcinogenesis [34,35].…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms in xenobiotic‐metabolizing genes and the risk of chronic lymphocytic leukemia and non‐Hodgkin's lymphoma in adult Russian patients

et al. 2007

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Polymorphisms in genes coding xenobiotic-metabolizing enzymes are considered as risk factors modifying susceptibility to cancer. We developed a biochip for the analysis of 18 mutations in 10 genes of metabolizing system: CYP1A1, CYP2D6, GSTT1, GSTM1, MTHFR, MTRR, NQO1, CYP2C9, CYP2C19, and NAT2. Using allele-specific hybridization on the biochip 76 T-cell non-Hodgkin's lymphoma (NHL) patients, 83 B-cell chronic lymphocytic leukemia (B-CLL) patients, and 177 healthy donors were tested. Polymorphic CYP1A1 alleles were more frequent in B-CLL patients relative to normal controls, for example, a combination of polymorphic variants 4887C > A, 4889A > G, and 6235T > C (OR 5 1.76, 95% CI 5 1.0-3.1). The GSTM1 null genotype was more frequent in NHL patients relative to controls (OR 5 1.82, 95% CI 5 1.1-3.1). The combination of unfavorable polymorphic CYP1A1 variants and GSTM1 null genotype was found more frequently in B-CLL patients relative to controls (OR 5 2.52, 95% CI 5 1.3-4.9). In addition, male B-CLL patients demonstrated a significantly increased occurrence of heterozygous and homozygous allele *2 of CYP2C9 gene (OR 5 2.38, 95% CI 5 1.1-5.2) as well as a combination of alleles *2 and *3 of the gene (OR 5 2.09, 95% CI 5 1.1-3.9). Thus, our findings show the association between polymorphic alleles of CYP1A1, GSTM1, and CYP2C9 genes and the risk to develop NHL or B-CLL. The developed biochip can be considered as a convenient analytical tool for research studies and predictive analysis in oncohematology. Am. J. Hematol. 83:279-287, 2008. V

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polymorphisms in xenobiotic‐metabolizing genes and the risk of chronic lymphocytic leukemia and non‐Hodgkin's lymphoma in adult Russian patients

et al. 2007

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“…We excluded 17 studies and one population of a study (five subjects were overlapped in other publications (Koushik et al, 2006;Wang et al, 2006;Vainer et al, 2010;Mohammad et al, 2011;Naushad et al, 2011a); genotype frequencies of eight studies were not provided (Lee et al, 2007;Gibson et al, 2011;Metayer et al, 2011;Naushad et al, 2011b;Piskac-Collier et al, 2011;Galbiatti et al, 2012;Lautner-Csorba et al, 2013;Swartz et al, 2013); and four studies (Wang et al, 2007b;Yu et al, 2007;Patino-Garcia et al, 2009;Curtin et al, 2011;Naushad et al, 2012) and one of populations in a study (Steck et al, 2008) did not conform to HWE). A total of 28 case-control studies with 29 populations met our inclusion criteria (Skibola et al, 2002;Hishida et al, 2003;Chen et al, 2004;Skibola et al, 2004;Lightfoot et al, 2005;Zhang et al, 2005;Niclot et al, 2006;Hazra et al, 2007;Lim et al, 2007;Lissowska et al, 2007;Moore et al, 2007;van den Donk et al, 2007;Wang et al, 2007a;Cheng et al, 2008;Guerreiro et al, 2008;Steck et al, 2008;Berglund et al, 2009;de Jonge et al, 2009;…”

Section: Methodsmentioning

confidence: 99%

C1420T Polymorphism of Cytosolic Serine Hydroxymethyltransferase and Risk of Cancer: a Meta-analysis

Zhong

Zhang²,

Hu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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A series of studies have explored the role of cytosolic serine hydroxymethyltransferase (SHMT1) C1420T polymorphism in cancer risk, but their results were conflicting rather than conclusive. To derive a more precise estimation of the association between C1420T and cancer risk, the present meta-analysis of 28 available studies with 15,121 cases and 18,023 controls was conducted. The results revealed that there was no significant association between the polymorphism and cancer risk overall. In stratified analysis by cancer type (breast cancer, gastrointestinal cancer, leukemia, lymphoma, and others), the results showed that 1420T allele was associated with decreased risk in leukemia . In summary, the findings suggest that SHMT1 C1420T polymorphism is not associated with overall cancer development, but might decrease cancer susceptibility of Asians as well as reduce leukemia risk. Large well-designed epidemiological studies will be necessary to validate the risk identified in the current meta-analysis.

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Polymorphisms involved in the folate metabolizing pathway and risk of multiple myeloma

Kim

Lee

et al. 2007

American J Hematol

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Folate and methionine metabolism plays an essential role in both DNA synthesis and methylation. Polymorphisms in the genes of the folate‐dependent enzymes have been shown to affect disease susceptibility. We conducted a Korean population‐based case‐control study to evaluate whether genetic variation in folate metabolism may have a role in the risk of multiple myeloma (MM). The study subjects were 173 patients with MM and 1,700 population‐based controls. The polymorphisms studied include methylenetetrahydrofolate reductase (MTHFR) 677 C > T and 1298 A > C, methionine synthase (MS) 2756 A > G, methionine synthase reductase (MTRR) 66A > G, thymidylate synthase (TS) 28‐bp repeat (2R→3R) and 6‐bp deletion/insertion. MS 2756 AG genotypes were associated with a 1.5‐fold lower risk of MM (OR = 0.66, 95%CI; 0.43–0.99, P = 0.047). There was no association between MTHFR C677T, A1298C, MTRR A66G, TS 2R→3R and 6‐bp deletion/insertion polymorphisms and MM. These results suggest that MTHFR C677T, A1298C, MTRR A66G, TS 2R→3R, and 6‐bp deletion/insertion do not significantly factor into the pathogenesis of MM in the Korean population, but that MS A2756G polymorphism may play an important role. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.

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Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas

Cited by 55 publications

References 43 publications

Polymorphisms in xenobiotic‐metabolizing genes and the risk of chronic lymphocytic leukemia and non‐Hodgkin's lymphoma in adult Russian patients

Polymorphisms in xenobiotic‐metabolizing genes and the risk of chronic lymphocytic leukemia and non‐Hodgkin's lymphoma in adult Russian patients

C1420T Polymorphism of Cytosolic Serine Hydroxymethyltransferase and Risk of Cancer: a Meta-analysis

Polymorphisms involved in the folate metabolizing pathway and risk of multiple myeloma

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