Risk of non-fatal cardiovascular diseases in early-onset versus late-onset type 2 diabetes in China: a cross-sectional study

Huo, Xiaoxu; Gao, Leili; Guo, Lixin; Xu, Wen; Wang, Wenbo; Zhi, Xiufang; Li, Ling; Ren, Yudong; Qi, Xiaojuan; Sun, Zilin; Li, Weidong; Ji, Qiuhe; Ran, Xingwu; Su, Benli; Hao, Chuan‐Ming; Lu, Juming; X, Guo; Zhuo, Hanjing; Zhang, Danyi; Pan, Changyu; Weng, Jianping; Hu, Dayi; Yang, Xilin; Ji, Linong

doi:10.1016/s2213-8587(15)00508-2

Cited by 185 publications

(167 citation statements)

References 33 publications

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“…Thirty-two (47.8%) patients had abnormal glucose metabolism in our study, and 13 of them were patients with T2DM. It was proved that GS patients were more likely to have diabetes (19.4 vs. 11.6%, p < 0.05) and even earlier onset age of DM (23.5 vs. 55 years) than general Chinese adults [29,30] , which could also be supported by reports in Taiwan [24] . It is acknowledged that chronic hypokalemia stops the closure of ATP-sensitive K + channels on pancreatic β-cells, which results in the decreased insulin secretion [24,[31][32][33][34][35][36][37] ; in addition, hypomagnesemia will reduce sensitivity of insulin to glucose with following insulin resistance [38] .…”

Section: Comorbid Diseases Of Gssupporting

confidence: 58%

Genotype/Phenotype Analysis in 67 Chinese Patients with Gitelman's Syndrome

Liu¹,

Wang²,

Lu³

et al. 2016

Am J Nephrol

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Background: Gitelman's syndrome (GS) is an autosomal recessive renal tubular disorder, which is caused by the mutations in SLC12A3. This study was designed to analyze the characteristics of the genotype and phenotype, and follow-up in the largest group of Chinese patients with GS. Methods: Sixty-seven patients with GS underwent SLCl2A3 analysis, and their clinical characteristics and biochemical findings as well as follow-up were reviewed, aiming to achieve a better description of GS. Additionally, the association of genotype and phenotype was explored. Results: Forty-one different mutations were identified within these 67 GS patients, including 11 novel mutations and 5 recurrent ones. Typical hypocalciuria and hypomagnesemia were not found in 6 (9%) and 8 (11.9%) patients, respectively. Male patients and those harboring severe mutations in both alleles had significant higher urinary fractional excretion (FE) of potassium, magnesium and chlorine. In addition, there were 2 patients who had chronic kidney disease (estimated glomerular filtration rate <60 ml/min/1.73 m²) and 32 patients with abnormal glucose metabolism. Conclusions: We identified 41 mutations related to GS, containing 11 novel variants and 5 high-frequency ones, which should facilitate earlier and more accurate diagnosis of GS. FE of electrolytes in urine may be more sensitive in the phenotype evaluation and differential diagnosis than corresponding serum electrolytes. Hypokalemia and hypomagnesemia in GS were difficult to correct; however, spironolactone might be helpful for hypokalemia to some degree. Compared with normal people, patients with GS were at higher risk of developing type 2 diabetes.

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Section: Comorbid Diseases Of Gssupporting

confidence: 58%

Genotype/Phenotype Analysis in 67 Chinese Patients with Gitelman's Syndrome

Liu¹,

Wang²,

Lu³

et al. 2016

Am J Nephrol

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“…Although type 2 diabetes is a disease related to aging, the prevalence of adult early-onset type has increased globally123. A higher proportion of early-onset diabetes was observed more frequently in Asian countries than in Western countries45.…”

mentioning

confidence: 99%

“…These patients lose up to 15 years of life expectancy, which is two-fold greater than the number of years lost by patients with late-onset diabetes9. In contrast to late-onset diabetes, early-onset diabetes is associated with a higher risk of developing cardiovascular and microvascular complications, which are largely due to prolonged disease exposure in both Westerners and Asians381011. A large number of early-onset diabetes patients receive inadequate anti-glycaemic treatment and suboptimal cardio-protective treatment, which may be partially attributed to the lack of knowledge regarding the harm of early-onset diabetes in daily clinical practice312.…”

mentioning

confidence: 99%

“…Studies in hospital settings indicate that early-onset diabetes patients have more extensive family history of diabetes, and higher body mass index (BMI), Haemoglobin A1c (HbA1c), and low-density lipoprotein cholesterol (LDL-C) level in Western countries and Asia1314, although there are disputes regarding the significance of these differences15. Large hospital based studies in China suggested early-onset diabetes participants had lower SBP, lower LDL-C, higher HbA1c and similar BMI and triglyceride levels compared with late-onset diabetes participants3. Selection bias in hospital-based studies is usually inevitable, particularly when using healthy participants who are recruited from hospitals as controls.…”

mentioning

confidence: 99%

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The characteristics of newly diagnosed adult early-onset diabetes: a population-based cross-sectional study

Zou

Zhou

et al. 2017

Sci Rep

Self Cite

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To investigate the characteristics of newly diagnosed early-onset diabetes in the Chinese population, 2801 newly diagnosed diabetes participants without known diabetes or pre-diabetes in a national cross-sectional survey were analysed. Participants were divided into quartiles (22–43, 44–52, 53–61 and >61 years) according to age of diabetes onset and the first group were defined as early-onset diabetes group. Early-onset diabetes group had lower systolic blood pressure (SBP), total cholesterol, low density lipoprotein cholesterol, 2-hour post prandial blood glucose and urine albumin creatinine ratio. There was no difference in body mass index, Homeostasis model assessment (HOMA) of beta cell function and diabetes family history between early-onset diabetes participants and any other age groups. HOMA of insulin resistance (IR) scores and disposition index 30 minutes after glucose load (DI30) were increased in early-onset diabetes participants. The beta cell function declination was more deteriorated in early-onset diabetes participants. Male gender, triglycerides, HOMA-IR and DI30 were positively associated with an earlier age at diagnosis. In conclusion, patients diagnosed with diabetes at a younger age are characterized by a similar cardiovascular risk profile with increased insulin resistance and more severe beta cell failure than patients diagnosed at a later age.

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“…На китайской популяции (n = 222,773) показан повышенный риск ССС при раннем дебюте диабета [59]. После стан-дартизации по возрасту и полу у пациентов с ранним началом СД риск нефатальных ССС был выше в сравне-нии с поздним началом диабета (11,1 vs 4,9%; p < 0,0001).…”

Section: в Digami-2 доказано что уровень гпн в остром периоде им явлunclassified

Problems of hypoglycemic therapy in diabetic patients with acute coronary syndrome

Руяткина¹,

Руяткин²,

Ovsyannikova³

2016

Med. sov.

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Risk of non-fatal cardiovascular diseases in early-onset versus late-onset type 2 diabetes in China: a cross-sectional study

Cited by 185 publications

References 33 publications

Genotype/Phenotype Analysis in 67 Chinese Patients with Gitelman's Syndrome

Genotype/Phenotype Analysis in 67 Chinese Patients with Gitelman's Syndrome

The characteristics of newly diagnosed adult early-onset diabetes: a population-based cross-sectional study

Problems of hypoglycemic therapy in diabetic patients with acute coronary syndrome

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