Risk of neural tube defects according to maternal body mass index: a systematic review and meta-analysis

Vena, Flaminia; D’Ambrosio, Valentina; Paladini, Vanessa; Saluzzi, Enrica; Mascio, Daniele Di; Boccherini, Chiara; Spiniello, Lorenzo; Mondo, Alessandro; Pizzuti, Antonio; Giancotti, Antonella

doi:10.1080/14767058.2021.1946789

Cited by 15 publications

(4 citation statements)

References 60 publications

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“…Our findings are consistent with the findings of Watkins et al, 20 which demonstrated that spina bifida– or anencephaly-affected pregnancy had an aOR (adjusted for age, education, chronic illness, smoking, alcohol, and vitamin use) of 1.62 for maternal BMI >26 to 29 kg/m 2 and 1.92 for BMI >29 kg/m 2 . A recent meta-analysis (Vena et al 21 [2022]), also found a significant association between maternal obesity and fetal spina bifida relative to women with normal BMI (odds ratio [OR], 1.69). However, unlike the findings of our study, there was no significant association between risk of NTDs and overweight BMI relative to normal BMI.…”

Section: Commentmentioning

confidence: 99%

Contribution of obesity to racial and ethnic disparities in the risk of fetal myelomeningocele: a population-based study

Mustafa,

Burns,

Heydari

et al. 2024

AJOG Global Reports

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Section: Commentmentioning

confidence: 99%

Contribution of obesity to racial and ethnic disparities in the risk of fetal myelomeningocele: a population-based study

Mustafa,

Burns,

Heydari

et al. 2024

AJOG Global Reports

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“…A recent meta-analysis of Vena et al included ten studies published from 2000 to 2017 and noted a similarly strong association between obesity and NTDs in the fetus (OR 1.62 95% CI 1.32–1.99), but no correlation of these fetal malformations with overweight [ 76 ].…”

Section: Fetal Abnormalities In Overweight and Obese Pregnant Womenmentioning

confidence: 99%

Obesity in prenatal medicine: a game changer?

Prodan,

Schmidt,

Hoopmann

et al. 2023

Arch Gynecol Obstet

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Obesity is recognized by the World Health Organization (WHO) as a disease in its own right. Moreover, obesity is an increasingly concerning public health issue across the world and its prevalence is rising amongst women of reproductive age. The fertility of over-weight and obese women is reduced and they experience a higher rate of miscarriage. In pregnant women obesity not only increases the risk of antenatal complications, such as preeclampsia and gestational diabetes, but also fetal abnormalities, and consequently the overall feto-maternal mortality. Ultrasound is one of the most valuable methods to predict and evaluate pregnancy complications. However, in overweight and obese pregnant women, the ultrasound examination is met with several challenges, mainly due to an impaired acoustic window. Overall obesity in pregnancy poses special challenges and constraints to the antenatal care and increases the rate of pregnancy complications, as well as complications later in life for the mother and child.

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“…In a series of 14 cases of acrania published by Gorgal et al, one mother known to have epilepsy was taking anticonvulsants and another one had uncontrolled diabetes mellitus [ 5 ]. In a recent meta-analysis published by Vena et al, maternal obesity proved to be a risk factor to NTDs in general with an odds ratio (OR) of 1.62 [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Fetal acrania diagnosed at 17 weeks of gestation by 2D/3D ultrasound: a case report and literature review

Ştefănescu,

Mihalache,

Constantin

et al. 2024

Rom J Morphol Embryol

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Acrania is a fetal malformation characterized by complete or partial absence of the calvaria above the orbits and supraciliary ridge. No exact mechanism is demonstrated for this anomaly but disturbances in mesenchymal migration during the fourth week of development are the most documented. The key sonographic features of acrania are absent calvaria and dorsally bulging brain (Mickey Mouse head). Due to the normal process of ossification of cranial bones, the diagnosis can be established only after 11 weeks of gestation. Early detection is extremely important. The prognosis is extremely poor so elective termination of pregnancy is the treatment of choice. In this paper, we discuss the things we know about pathogeny and ultrasonographic features of fetal cranial malformations based on a case diagnosed late during gestation.

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Risk of neural tube defects according to maternal body mass index: a systematic review and meta-analysis

Cited by 15 publications

References 60 publications

Contribution of obesity to racial and ethnic disparities in the risk of fetal myelomeningocele: a population-based study

Contribution of obesity to racial and ethnic disparities in the risk of fetal myelomeningocele: a population-based study

Obesity in prenatal medicine: a game changer?

Fetal acrania diagnosed at 17 weeks of gestation by 2D/3D ultrasound: a case report and literature review

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