Risk of metachronous advanced lesions after resection of diminutive and small, non-advanced adenomas

Laish, Ido; Сергеев, И. В.; Stein, Assaf; Naftali, Timna; Konikoff, Fred M.

doi:10.1016/j.clinre.2018.03.001

Cited by 12 publications

(10 citation statements)

References 23 publications

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“…Similar to our results, Sneh Arbib et al 22 revealed that among patients with 1 to 2 polyps, those with at least 1 polyp of 6 to 9 mm in size with low-grade dysplasia presented a significantly higher risk of ACRN on follow-up when compared with patients with polyps sized 1 to 5 mm (aHR, 5.25; 95% CI, 1.82-15.09). However, contrary to our findings, Laish et al 23 showed that of patients who underwent polypectomy of up to 2 NAAs, individuals with diminutive adenomas and small adenomas had the same risk of metachronous ACRN. In the study by Laish et al, among patients presenting with diminutive adenomas (n Z 395) and small adenomas (n Z 110), ACRN was identified in 68 patients (17.2%) and 16 patients (14.5%), respectively (P Z .53), during a mean follow-up of 4.3 AE .9 years.…”

Section: Discussioncontrasting

confidence: 99%

Risk of developing metachronous advanced colorectal neoplasia after resection of low-risk diminutive versus small adenomas

Kim

Jung

Park

et al. 2020

Gastrointestinal Endoscopy

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Section: Discussioncontrasting

confidence: 99%

Risk of developing metachronous advanced colorectal neoplasia after resection of low-risk diminutive versus small adenomas

Kim

Jung

Park

et al. 2020

Gastrointestinal Endoscopy

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“…Recent studies have improved our understanding of CRC risk versus detected adenoma size and multiplicity of lesions. Diminutive polyps (< 5 mm in size) alone may present an increased risk of advanced metachronous adenomas, compared with no polyps at all [14]. A recent study found an increased risk with three or more diminutive adenomas even versus one to two larger non-advanced adenomas [15].…”

Section: Conclusion Low-volume Ner1006 Enhances High-qualitymentioning

confidence: 99%

High-quality colon cleansing and multiple neoplasia detection with 1L NER1006 versus mid-volume options: Post hoc analysis of phase 3 clinical trials

Epstein¹,

Bénamouzig

Halonen

et al. 2020

Endosc Int Open

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Background and study aims Multiple neoplasia increase the risk of colorectal cancer. High-quality cleansing may improve adenoma detection. We assessed whether a new bowel preparation can improve colon cleansing and multiple lesion detection. Patients and methods This post hoc analysis of two randomized clinical trials in Europe and the US assessed the per study and combined cleansing efficacy of overnight split dosing with (preparation + clear fluids) 1 + 1 L polyethylene glycol (PEG) NER1006 versus 2 + 1 L PEG + ascorbate (2LPEG) or 1 + 2 L oral sulfate solution (OSS) combined. Treatment-blinded central readers assessed cleansing quality using the Harefield Cleansing Scale (HCS). Patients with full segmental scoring were included. HCS segmental scores 0–4 (high-quality = HCS 3–4) were analyzed for NER1006 versus 2LPEG/OSS. Mean number of polyps or adenomas per patient (MPP/MAP) was calculated for treatments in patients with at least one polyp or adenoma. Results In 1037 patients, NER1006 attained a greater rate of HCS 3 scores (29 % vs. 20 %; P < 0.001) and HCS 4 scores (20 % vs. 17 %; P = 0.007) versus 2LPEG/OSS. More polyps (678 versus 585) and adenomas (397 versus 331) were detected with NER1006 (N = 517) versus 2LPEG/OSS (N = 520). In all neoplasia-positive patients, with increasing minimal per-patient neoplasia multiplicity from 1 to 10, NER1006 numerically improved MPP (difference ± SE: 0.48 ± 0.24 to 3.89 ± 3.37) and MAP (0.47 ± 0.26 to 7.50 ± 9.00) versus 2LPEG/OSS. Conclusions Low-volume NER1006 enhances high-quality cleansing versus medium-volume 2LPEG or OSS, individually and when combined. NER1006 may consequently facilitate the detection of multiple neoplasia in patients.

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“…Sclerotic glandular foci, which are characterized by a decreased number of Brunner’s glands with irregular structure and angulation, sparse cytoplasm, and centered nucleus, can be also seen [ 10 ]. Metachronous lesions of Brunner’s gland hamartoma have not been reported in the literature yet, but they can be observed in other gastrointestinal tract diseases, such as gastric epithelia dysplasia [ 43 ] and colorectal adenomas [ 44 ]. Immunohistochemically, Brunner’s glands always express MUC6 at different levels, and some dilated or angulated Brunner’s glands also express MUC5AC simultaneously.…”

Section: Diagnostic Approachesmentioning

confidence: 99%

Brunner’s Gland Hamartoma of the Duodenum: A Literature Review

Zhu

et al. 2021

Adv Ther

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Brunner's gland hamartoma is a benign tumor of the duodenum, but has malignant potential with a very low risk of progression into adenocarcinoma. It is uncommon with a frequency of less than 1.0% among the primary tumors of the small intestine. In addition, its clinical manifestations are nonspecific, etiology remains unclear, and treatment strategy needs to be further refined. This literature review mainly discusses the epidemiology, clinical features, possible etiology and pathogenesis, diagnostic methods, malignant potential, treatment, and prognosis of Brunner's gland hamartoma.

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Risk of metachronous advanced lesions after resection of diminutive and small, non-advanced adenomas

Cited by 12 publications

References 23 publications

Risk of developing metachronous advanced colorectal neoplasia after resection of low-risk diminutive versus small adenomas

Risk of developing metachronous advanced colorectal neoplasia after resection of low-risk diminutive versus small adenomas

High-quality colon cleansing and multiple neoplasia detection with 1L NER1006 versus mid-volume options: Post hoc analysis of phase 3 clinical trials

Brunner’s Gland Hamartoma of the Duodenum: A Literature Review

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