Risk of metabolic syndrome in patients with lichen planus: A systematic review and meta-analysis

Abstract

Background Studies have investigated whether patients with lichen planus are at a high risk of metabolic syndrome; however, currently, no conclusive data are available in this regard. Objective This meta-analysis was performed to analyze the published literature investigating the association between metabolic syndrome and lichen planus. Method Two reviewers independently searched 4 databases (PubMed, Embase, the Cochrane Library and Web of Science) for observational studies assessing the prevalence of metabolic syndrome in patients with lichen planus. Review Manager 5.3 software was used to statistically analyze the data. Results 200 relevant articles were searched. After a further reading, 12 studies with 1422 participants (715 with LP and 707 controls) fulfilled the eligibility criteria. Overall, the pooled odds ratio based on random effects analysis was 2.81 (95% confidence interval: 1.79-4.41, P<0.00001). This meta-analysis shows that compared with the general population, patients with lichen planus are more likely to develop metabolic syndrome. Subgroup analysis of prevalence of metabolic syndrome showed higher odds ratio in studies using International Diabetes Federation diagnostic criteria (odds ratio 4.65) and the Harmonized criteria (odds ratio 26.62) than studies using National Cholesterol Education Program Adult Treatment Panel III criteria (odds ratio 1.75), and thus might be more appropriate for diagnosing metabolic syndrome.

Difficulties in the Treatment of Oral Lichen Planus in a Systemically Compromised Patient: Case Report and Review of the Literature

“…El caso reportado presenta características clínicas e histológicas coincidentes con la literatura, con la diferencia que se trata de un hombre y el LPO se ha reportado con predominio en mujeres (3). Así mismo, se trata de un paciente diabético e hipertenso con niveles elevados de LDL, lo que resulta importante, ya que los pacientes con LP tienen más probabilidades de desarrollar síndrome metabólico (12).…”

“…Estos síntomas clínicos pueden hacer que los pacientes sean propensos al desarrollo de estrés, ansiedad y depresión, lo que empeora el cuadro (11). Además, el LP se ha relacionado con numerosas connotaciones sistémicas como diabetes mellitus (DM), hipertensión, síndrome metabólico, enfermedades de la tiroides, dolencias psicosomáticas, enfermedad hepática crónica, enfermedades gastrointestinales y susceptibilidad genética al cáncer (4,12,13).…”

Early identification of metabolic syndrome risk: A review of reviews and proposal for defining pre-metabolic syndrome status

“…Li et al (2020) observed that is not associated with CVD [49]; however, Cheng et al (2020) found that rosacea is associated with hypertension and high levels of LDL and low HDL [50]. Furthermore, people presenting lichen planus (LP), which is an idiopathic inflammatory dermatosis, are more likely to be affected by MetSyn [51].…”

Circulating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus—Preliminary Data

“…One of other types is eruptive LP, which presents with numerous papules spread on the large body surface. Nowadays, LP is suspected to be associated with MS, similar to psoriasis [ 19 ].…”

“…Their pathogenesis is not fully understood, but autoimmune factors are suspected as one of the possible paths, along with drugs, infections, and stress that can trigger the lesions’ occurrence [ 12 , 15 ]. Moreover, both PSO and LP have been related to components of MS [ 6 , 19 ].…”