Circulating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus—Preliminary Data

Abstract

Plaque psoriasis (PSO) and lichen planus (LP) are skin diseases with some similarities in pathogenesis, comorbidities, and clinical presentation. Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and its ligand, α4β7 integrin, are involved in inflammatory bowel diseases and liver dysfunctions, which occur more frequently in PSO and LP. Serum MAdCAM-1 and ITGB7 levels in patients with plaque PSO and eruptive LP have never been studied before. The study included 42 patients with PSO, 13 with LP, and 23 controls. Serum molecules levels were evaluated using the immune–enzymatic method. ITGB7 concentration was not statistically different, both in patients with PSO and LP, compared to controls (both p > 0.05). MAdCAM-1 level was significantly lower in PSO subjects than in controls (p = 0.041), whereas in the LP group, a downward trend was observed (p = 0.088) with p = 0.0455 in ANOVA. Multiple linear regression revealed independent associations between ITGB7 and HDL and BMI and RBC in the LP group. In psoriatic patients with elevated CRP, there was an upward trend for MAdCAM-1, and also a positive correlation between MAdCAM-1 and WBC. ITGB7 and MAdCAM-1 cannot serve as markers of disease activity or liver pathology neither in patients with PSO nor LP. MAdCAM-1 might play a role as an inflammation indicator in PSO and a beneficial influence on the lipid profile in LP.

Potential Predictive Value of Serum Pentraxin 3 and Paraoxonase 1 for Cardiometabolic Disorders Development in Patients with Psoriasis—Preliminary Data

“…Psoriasis may be associated with comorbidities, such as arthritis [ 1 , 2 ]. Even though psoriasis is considered to be a common disease, affecting 2–3% of the general population, its pathogenesis is not comprehended, but environmental, genetic, autoimmune and auto-inflammatory factors are considered to be potential causes [ 3 , 4 ]. It is believed that inflammatory cytokines, interleukin-1 and oxidative stress contribute to the development of the disease [ 5 ].…”

Psoriasis and neurodegenerative diseases—a review

“…Genetic factors have been taken into consideration in the pathogenesis of psoriasis and some of the NDs for a long time. Indeed, genetic predisposition has been proved for psoriasis and AD, PD, and ALS (Brown et al, 2005 ; Hulisz, 2018 ; Baran et al, 2021 ). Besides the original studies on genetic issues in psoriasis described above, we have also found some evidence considering the common genetic backgrounds for psoriasis and NDs.…”

“…Inflammation has an undeniable role in the pathogenesis of psoriasis, which is currently perceived not only as a skin disease but even as a chronic, general, inflammatory condition (Schultze and SYSCID consortium, 2018 ; Baran et al, 2021 ). Considering the tight association between psoriasis and metabolic syndrome (MS), there has been a term called “metaflammation” proposed, which indicates metabolically induced inflammation in psoriatic patients (Nowowiejska et al, 2020 ).…”

“…The pathogenesis of psoriasis is multifactorial. Genetic, as well as immunological and environmental factors are considered (Baran et al, 2021 ). There are many chromosomal loci identified, which provide susceptibility for psoriasis development (Rendon and Schäkel, 2019 ).…”

“…The immune pathways in psoriasis involve antimicrobial peptides (AMPs), dendritic cells (DCs), Th17 lymphocytes, tumor necrosis factor (TNF) α, interleukins (IL) 17, 22, 23, and signal transducer and activator of transcription (STAT) 3 (Tokuyama and Mabuchi, 2020 ). Flares of psoriasis may be triggered by several environmental stimuli, such as stress, infection, alcohol consumption, or particular medicine intake (Baran et al, 2021 ). As for the treatment, there are numerous methods, including topical as well as systemic options (Nowowiejska et al, 2020 ).…”