Risk of Hypotony in Juvenile Idiopathic Arthritis–Associated Uveitis

Moradi, Ahmadreza; Stroh, Inna G.; Reddy, Ashvini K.; Hornbeak, Dana M.; Leung, Theresa G.; Burkholder, Bryn M.; Thorne, Jennifer E.

doi:10.1016/j.ajo.2016.06.026

Cited by 14 publications

(7 citation statements)

References 32 publications

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“… 3 , 15 , 43 In addition, patients may present with hypotony, defined as intraocular pressure (IOP) < 5 mm Hg or IOP ⩾ 5, but < 8 mm Hg, which adversely affects visual potential. 44 …”

Section: Imaging In Pediatric Uveitismentioning

confidence: 99%

Multimodal imaging in pediatric uveitis

et al. 2021

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Pediatric uveitis accounts for up to 10% of all uveitis cases, so special attention must be paid to ensure early diagnosis as well as treatment and follow-up of these young patients in order to decrease the risk of possible ocular complications and consequently vision loss. Multimodal imaging has been an effective and important adjunct in the diagnoses and management of uveitis, especially in children. Reviewed here are the currently utilized modalities, advances, as well as their applications in juvenile idiopathic arthritis–associated uveitis, pars planitis, retinal vasculitis, tubulointerstitial nephritis and uveitis syndrome, Behçet disease, Blau syndrome, and Vogt–Koyanagi–Harada syndrome.

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“… 3 , 15 , 43 In addition, patients may present with hypotony, defined as intraocular pressure (IOP) < 5 mm Hg or IOP ⩾ 5, but < 8 mm Hg, which adversely affects visual potential. 44 …”

Section: Imaging In Pediatric Uveitismentioning

confidence: 99%

Multimodal imaging in pediatric uveitis

et al. 2021

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“…If scarring occurs and the fibrin is replaced by fibroblast-containing scar tissue, the drug-based synechiolysis is usually no linger possible. Posterior synechiae are prognostically unfavourable in the case of chromic inflammation and ocular hypotension [34,38].…”

Section: Posterior Synechiamentioning

confidence: 99%

“…Additionally, the leakage of protein from retinal and uveal vessels (Tyndall in the anterior chamber) is increased. Chronic ocular hypotension increases the risk of developing phthisis bulbi and serious visual impairment/blindness [38]. System treatment with DMARDs reduces the risk of developing hypotension [38].…”

Section: Ocular Hypotensionmentioning

confidence: 99%

“…Chronic ocular hypotension increases the risk of developing phthisis bulbi and serious visual impairment/blindness [38]. System treatment with DMARDs reduces the risk of developing hypotension [38]. If a case of hypotension already exists, the administration of topical and systemic steroids, the switch to conventional or biological DMARDs and, if necessary, the intensification of a systemic DMARD only have limited effectiveness.…”

Section: Ocular Hypotensionmentioning

confidence: 99%

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Childhood Uveitis

Thurau

2020

Klin Monbl Augenheilkd

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Childhood uveitis is an ophthalmological challenge, since on the one hand it often remains asymptomatic and difficult to detect, and on the other hand it often has a chronic course and is associated with a high risk of complications threatening the vision. The most important risk factors for childhood uveitis are underlying rheumatic diseases; recommendations for ophthalmological monitoring have been developed together with paediatric rheumatologists. Intermediate and posterior uveitis are rare in children. The therapy must effectively control inflammation and at the same time cause only minimal side effects. Since steroids in particular cause side effects frequently, an immunosuppressive therapy must be initiated early in an interdisciplinary cooperation with paediatric rheumatologists and parents with the goal of minimising steroids.

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“…Different studies have pointed out that several factors are associated with poor prognosis, including young age at onset, male gender, short interval between diagnosis of arthritis and uveitis, severity of uveitis at onset and ANA positivity. [11][12][13][14] Unilateral permanent visual loss at the age of 18 was observed in 33% of the patients and bilateral visual loss occurred in 4%. 15 Although uveitis in JIA is considered a disease of childhood, the majority of the patients experience persistent ocular inflammation into adulthood.…”

Section: Sarcoidosis-associated Anterior Uveitismentioning

confidence: 99%

Challenges of Diagnosing Viral Anterior Uveitis

Groen-Hakan

Babu²,

Tuğal-Tutkun

et al. 2017

Ocular Immunology and Inflammation

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The viral causes of anterior uveitis (AU) emerged with the use of novel molecular diagnostic tests and serologic tests adapted for small volumes (Goldmann-Witmer Coefficient). The viral causes of AU may be underestimated, and some of the presumed idiopathic AU cases will probably be proven to be of viral origin in the coming years. So far, a viral origin of AU was suspected in patients who presented with unilateral hypertensive AU. It is not clear which clinical presentations should raise a suspicion of viral etiology. There is an overlap in the clinical manifestations of AU caused by viruses and other non-viral forms of AU. A viral cause of AU should be suspected in patients with unilateral AU, exhibiting small or medium sized KPs, some form of iris atrophy, high IOP and early development of a cataract and the definitive diagnosis can be proven by aqueous humor analysis.

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Risk of Hypotony in Juvenile Idiopathic Arthritis–Associated Uveitis

Cited by 14 publications

References 32 publications

Multimodal imaging in pediatric uveitis

Multimodal imaging in pediatric uveitis

Childhood Uveitis

Challenges of Diagnosing Viral Anterior Uveitis

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