Risk of hospitalization among survivors of childhood and adolescent acute lymphoblastic leukemia compared to siblings and a general population sample

Ou, Judy Y.; Smits-Seemann, Rochelle R.; Kaul, Sanjana; Fluchel, Mark; Sweeney, Carol; Kirchhoff, Anne C.

doi:10.1016/j.canep.2017.06.005

Cited by 12 publications

(16 citation statements)

References 30 publications

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“…Motor impairment can lead to decreased physical activity, obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease . A recent study by Ou et al . found that pediatric survivors 5–10 years post‐ALL diagnosis and only receiving chemotherapy had significantly more hospitalizations after completion of ALL treatment than that of the general population, thus suggesting the presence of late‐effect health burdens in cancer survivors.…”

mentioning

confidence: 99%

Genetic Variants Associated With Vincristine‐Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia

Sajdyk

Smith

et al. 2019

Clin Pharma and Therapeutics

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Vincristine is one of the core chemotherapy agents used in the treatment of pediatric acute lymphoblastic leukemia (ALL). However, one of the major toxicities resulting from vincristine exposure is vincristine‐induced peripheral neuropathy (VIPN). When VIPN results in significant morbidity, the vincristine dose may need to be reduced, thus potentially decreasing the effectiveness of treatment. To date, there are no robust biomarkers used clinically to determine which patients will be at risk for worse neuropathy. The current study included genomewide association study (GWAS) in two independent cohorts: Pediatric Oncology Group (POG) ALL trials and a multicenter study based at Indiana University in children with ALL. A meta‐analysis of the cohorts identified two single‐nucleotide polymorphisms (SNPs), rs1045644 and rs7963521, as being significantly (P value threshold 0.05/4749 = 1.05E‐05) associated with neuropathy. Subsequently these SNPs may be effective biomarkers of VIPN in children with ALL.

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mentioning

confidence: 99%

Genetic Variants Associated With Vincristine‐Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia

Sajdyk

Smith

et al. 2019

Clin Pharma and Therapeutics

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“…Emergency departments are available to the public and as a consequence, ED admission does not always equate to urgent needs or severe disease [59,60]. In contrast, hospitalizations require a clinician or ED referral and may indicate more severe disease or conditions [32,60].…”

Section: Discussionmentioning

confidence: 99%

“…This case-crossover study was nested in a cohort used in previous studies of Utah childhood cancer survivors [10,31,32]. From this cohort we identified 3819 survivors who were diagnosed with a childhood cancer at age ≤25 years from 1 January 1986 and 31 December 2012, diagnosed or treated at Primary Children’s Hospital (PCH) in Salt Lake City, Utah, and alive ≥5 years from diagnosis.…”

Section: Methodsmentioning

confidence: 99%

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Fine Particulate Matter and Respiratory Healthcare Encounters among Survivors of Childhood Cancers

Hanson

Ramsay

et al. 2019

IJERPH

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Some chemotherapies that treat childhood cancers have pulmonary-toxic properties that increase risk for adverse respiratory-health outcomes. PM2.5 causes similar outcomes but its effect among pulmonary compromised cancer survivors is unknown. This case-crossover study identified the PM2.5-associated odds for primary-respiratory hospitalizations and emergency department visits among childhood cancer survivors in Utah. We compared risk among chemotherapy-treated survivors to a cancer-free sample. We calculated 3-day-average PM2.5 by ZIP code and county for event and control days. Conditional logistic regression estimated odds ratios. Models were stratified by cause of admission (infection, respiratory disease, asthma), previous chemotherapy, National Ambient Air Quality Standard (NAAQS), and other variables. Results are presented per 10 µg/m3 of PM2.5. 90% of events occurred at 3-day PM2.5 averages <35.4 µg/m3, the NAAQS 24-h standard. For survivors, PM2.5 was associated with respiratory hospitalizations (OR = 1.84, 95% CI = 1.13–3.00) and hospitalizations from respiratory infection (OR = 2.09, 95% CI = 1.06–4.14). Among chemotherapy-treated survivors, the PM2.5-associated odds of respiratory hospitalization (OR = 2.03, 95% CI = 1.14–3.61) were significantly higher than the cancer-free sample (OR = 0.84, 95% CI = 0.57–1.25). This is the first study to report significant associations between PM2.5 and respiratory healthcare encounters in childhood cancer survivors. Chemotherapy-treated survivors displayed the highest odds of hospitalization due to PM2.5 exposure and their risk is significantly higher than a cancer-free sample.

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“…(4)(5)(6) With respect to the latter, however, much of the information on late effects among survivors has come either from analyses of hospitalizations or from questionnaires completed by consenting individuals. (7)(8)(9)(10)(11)(12)(13)(14)(15)(16) As is evident from the studies summarized in Table 1 (which includes those that examined all leukaemias combined and those that also included young adults), less attention has been paid to chronic conditions that do not require hospital admission, (17,18) and to morbidity patterns that change over time. (11,19) The longitudinal data examined in this report contain information on hospital outpatient attendances, as well as inpatient episodes, cancer registrations, and deaths.…”

Section: Introductionmentioning

confidence: 99%

Excess morbidity and mortality among survivors of childhood acute lymphoblastic leukaemia: 25 years of follow-up from the United Kingdom Childhood Cancer Study (UKCCS)

Kane

Kinsey

Bonaventure

et al. 2021

Preprint

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Objectives To examine morbidity and mortality in survivors of childhood acute lymphoblastic leukaemia (ALL) across their teenage and young adult (TYA) years; comparing the patterns observed with individually matched general population controls. Design Case-control study with follow-up linkage to administrative healthcare databases for up to 25 years. Setting The study population comprises all children (0-14 years) registered for primary care with the National Health Service (NHS) in England 1992-1996. Participants 1082 five-year survivors of ALL diagnosed <15 years of age, and 2018 age- and sex-matched population-based controls; followed to 15 March 2020. Main outcome measures Associations with hospital activity, cancer, and mortality were assessed using incidence rate ratios and absolute risk difference. Results Mortality 5-25 years after diagnosis was 20 times higher in cases than controls (Rate Ratio 21.3, 95% Confidence Interval 11.2-45.6), and cancer incidence 10 time higher (IRR 9.9 95% CI 4.1-29.1). Hospital activity was increased for many clinical specialties, the strongest effects being for endocrinology; outpatient IRR 36.7, 95% CI 17.3-93.4 and inpatient 19.7, 95% CI 1.9-25.5 for males, and 11.0, 95% CI 6.2-21.1 and 6.2 95% CI 3.1-13.5 respectively for females. Notable excesses were also evident for cardiology, neurology, ophthalmology, respiratory medicine and general medicine. Males were also more likely to attend gastroenterology, ENT (ear, nose and throat), urology, and dermatology; while females were more likely to be seen in plastic surgery and less likely in midwifery. Conclusions Adding to a large excess risk of death and cancer, survivors of childhood ALL experience excess outpatient and inpatient activity across their TYA years. Involving most clinical specialties, the observed effects are striking, showing no signs of diminishing over the first 25 years of follow-up. These findings underscore the need to take prior ALL drug and/or radiation treatment into account when interpreting seemingly unrelated symptoms in later life.

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Risk of hospitalization among survivors of childhood and adolescent acute lymphoblastic leukemia compared to siblings and a general population sample

Abstract: Five to ten years after diagnosis is a sensitive time period for hospitalizations in the ALL population. Survivors of childhood ALL require better long-term surveillance.

Cited by 12 publications

References 30 publications

Genetic Variants Associated With Vincristine‐Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia

Genetic Variants Associated With Vincristine‐Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia

Fine Particulate Matter and Respiratory Healthcare Encounters among Survivors of Childhood Cancers

Excess morbidity and mortality among survivors of childhood acute lymphoblastic leukaemia: 25 years of follow-up from the United Kingdom Childhood Cancer Study (UKCCS)

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