Risk of hip fracture with hip or knee osteoarthritis: a systematic review

Chudyk, Anna M.; Ashe, Maureen C.; Gorman, Erin; Tunaiji, Hashel Al; Crossley, Kay M

doi:10.1007/s10067-012-1970-z

Cited by 22 publications

(16 citation statements)

References 45 publications

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“…Thus, to decrease the prevalence of hip fracture, multifaceted interventions for preventing hip fracture are urgently needed [6]–[8]. To make more effective therapeutic or lifestyle interventions, we need have a better knowledge of both the risk factors and the protective factors of hip fracture [9]–[11]. Low body mass index (BMI) is a recognized risk factor for fracture, particularly for the hip fracture [7], [12].…”

Section: Introductionmentioning

confidence: 99%

Obesity and Risk of Hip Fracture in Adults: A Meta-Analysis of Prospective Cohort Studies

et al. 2013

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BackgroundMany observational studies assessed the association between obesity and risk of hip fracture in adults, but reported controversial results. Our goal was to evaluate the association between obesity and risk of hip fracture in adults by conducting a meta-analysis of prospective cohort studies.MethodsThree databases, PubMed, Embase and Web of Science, were searched through May 2012 to identify eligible cohort studies. Either a fixed- or a random-effects model was used to calculate the pooled relative risk (RR) with its 95% confidence interval (95%CI).ResultsFifteen prospective cohort studies involving a total 3,126,313 participants were finally included into this meta-analysis. Overall, adults with obesity compared with the normal weight group had a significantly decreased risk of hip fracture (RR: 0.66, 95% CI 0.57 to 0.77, P<0.001). Meta-analyses by the adjusted status of RRs also suggested adults with obesity compared with the reference group had a significantly decreased risk of hip fracture (adjusted RR: 0.48, 95% CI 0.39 to 0.58, P<0.001; unadjusted RR: 0.66, 95% CI 0.56 to 0.78, P<0.001). Subgroup analyses by gender suggested individuals with obesity had a significantly decreased risk for developing hip fracture compared with the reference group in both men (RR 0.54, 95% CI 0.48 to 0.60, P<0.001) and women (RR 0.70, 95% CI 0.58 to 0.84, P<0.001). No evidence of publication bias was observed in this meta-analysis.ConclusionsThis meta-analysis of prospective cohort studies suggests that obesity significantly decreases the risk of hip fracture in adults, and obesity is probably a protective factor of hip fracture in adults.

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Section: Introductionmentioning

confidence: 99%

Obesity and Risk of Hip Fracture in Adults: A Meta-Analysis of Prospective Cohort Studies

et al. 2013

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“…Hip fracture, the most serious complication of osteoporosis, is a common musculoskeletal disorder [1]. It accounts for the majority of fracture related health care expenditure and mortality in men and women over the age of 50 years worldwide [2], [3].…”

Section: Introductionmentioning

confidence: 99%

Association between Estrogen Receptor α Gene (ESR1) PvuII (C/T) and XbaI (A/G) Polymorphisms and Hip Fracture Risk: Evidence from a Meta-Analysis

Guo-lin

2013

PLoS ONE

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Background and ObjectiveGenetic factors are important in the pathogenesis of fractures. Notably, estrogen receptor α (ESR1) has been suggested as a possible candidate gene for hip fractures; however, published studies of ESR1 gene polymorphisms have been hampered by small sample sizes and inconclusive or ambiguous results. The aim of this meta-analysis is to investigate the associations between two novel common ESR1 polymorphisms (intron 1 polymorphisms PvuII-rs2234693: C>T and XbaI-rs9340799: A>G) and hip fracture.MethodsCrude odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of the association.ResultsFive case-control and three cohort studies were assessed, including a total of 1,838 hip fracture cases and 14,972 healthy controls. This meta-analysis revealed that the PvuII T allele is a highly significant risk factor for hip fracture susceptibility, with an effect magnitude similar in male and pre-menopausal and post-menopausal female patients. In stratified analysis based on ethnicity, the PvuII T allele remained significantly correlated with increased risk of hip fracture in Caucasian populations; this correlation, however, was not found in Asian populations. Unlike the PvuII polymorphism, we did not find significant differences in the XbaI (A>G) polymorphism allele or genotype distributions of hip fracture patients and controls. We also found no obvious association between the XbaI polymorphism and hip fracture in any of the racial or gender subgroups.ConclusionOur findings show that the ESR1 PvuII T allele may increase the risk of hip fracture and that the XbaI polymorphism is not associated with hip fracture.

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“…This would explain the occurrence of a dislocation instead of a femoral neck fracture and, also, the occurrence of a pure dislocation, i.e., not accompanied by any fracture of the acetabulum. However, the clinical correlation between hip osteoarthritis and fracture of the proximal femur remains controversial [16][17][18][19]. Finally, some suggested that a low anteversion of the proximal femur or even a retroversion would favor a traumatic hip dislocation [3,20].…”

Section: Discussionmentioning

confidence: 99%

Are traumatic hip dislocations of the young and the elderly comparable: review of the literature from a recent case

Gerosa

Aurégan

Letellier

et al. 2015

Eur Orthop Traumatol

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Traumatic hip dislocation is a condition mostly encountered among young patients. However, clinical series reported regularly cases among elderly. From those, it seems that traumatic hip dislocation in young and elderly patients have a different profile. We present the case of a traumatic hip dislocation in a patient of 81 years secondary to a fall from his height. No fracture occurred. The dislocation was reduced by external maneuvers 3 h after the trauma. At last follow-up of 1 year, the patient developed a secondary hip osteoarthritis despite any articular incongruence. From a review of the literature, we found that epidemiology, pathophysiology, and prognosis of traumatic dislocation of the hip in the elderly may be different than those in young subjects. Hence, we suggest that the two conditions should be separated.Level of evidence: V. Expert opinion.

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Risk of hip fracture with hip or knee osteoarthritis: a systematic review

Cited by 22 publications

References 45 publications

Obesity and Risk of Hip Fracture in Adults: A Meta-Analysis of Prospective Cohort Studies

Obesity and Risk of Hip Fracture in Adults: A Meta-Analysis of Prospective Cohort Studies

Association between Estrogen Receptor α Gene (ESR1) PvuII (C/T) and XbaI (A/G) Polymorphisms and Hip Fracture Risk: Evidence from a Meta-Analysis

Are traumatic hip dislocations of the young and the elderly comparable: review of the literature from a recent case

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