Risk of gastroschisis with maternal genitourinary infections: the US National birth defects prevention study 1997–2011

Feldkamp, Marcia L.; Arnold, Kathryn E.; Krikov, Sergey; Reefhuis, Jennita; Almli, Lynn M.; Moore, Cynthia A.; Botto, Lorenzo D.

doi:10.1136/bmjopen-2018-026297

Cited by 21 publications

(37 citation statements)

References 60 publications

(72 reference statements)

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“…The prevalence of gastroschisis is higher in PUB hospitals, especially in the south. There is evidence that gastroschisis is associated with young maternal age (< 20 years) (Goldbaum et al 1990;Castilla et al 2008;Baer et al 2015) and probably with recurrent genitourinary infections in young women (Feldkamp et al 2019). In our study, maternal age under 20 was 14.5% and 17.4% in PUB-N and PUB-S hospitals, respectively, and 2.0% and 6.1% in PRI-N and PRI-S hospitals, respectively.…”

Section: Discussionmentioning

confidence: 43%

Birth prevalence of congenital anomalies in the City of Buenos Aires, Argentina, according to socioeconomic level

et al. 2020

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The goal of our study is to describe the prevalence of congenital anomalies (CA) in hospitals of the City of Buenos Aires, Argentina, according to two proxy variables of the socioeconomic level: health subsector, public (PUB) versus private/social security (PRI), and geographical location, northern (N) versus southern (S). The source of data was the National Network of Congenital Anomalies of Argentina (RENAC) (period 2010-2016). From a total of 228,208 births, 4872 newborns with CA were detected (2.14%). The prevalence in PRI-N, PUB-N, PRI-S, and PUBS hospitals were 1.59%, 1.91%, 2.20%, and 2.43%, respectively. Prevalence of neural tube defects, abdominal wall defects, and oral clefts was significantly higher in PUB than in PRI hospitals. Prevalence of critical heart defects was significantly lower in PUB-N and in PRI-S hospitals. Prevalence of anencephaly, encephalocele, hydrocephalus, microcephaly, gastroschisis, cleft lip and palate, ductus arteriosus, and bilateral renal agenesis was higher in PUB hospitals, both N and S, as well as microphthalmia/anophthalmia and ambiguous genitalia, spina bifida, anotia/microtia, postaxial polydactyly, and diaphragmatic hernia had higher prevalences in PUBS hospitals. Omphalocele was more frequent in PUB-N hospitals. Results suggest that vulnerable populations in the public and southern subsectors of the city still require a greater support to reinforce resources and strategies that lead to greater equity in access to health.

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Section: Discussionmentioning

confidence: 43%

Birth prevalence of congenital anomalies in the City of Buenos Aires, Argentina, according to socioeconomic level

et al. 2020

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“…In a Canadian cohort study involving two large databases, smoking (odds ratio (OR), 2.86; 95% CI, 2.22–3.66), a history of pregestational or gestational diabetes (OR, 2.81; 95% CI, 1.42–5.5), and use of medication to treat depression (OR, 4.4; 95% CI, 1.38–11.8) emerged as significant associations with gastroschisis pregnancies [ 20 ]. The National Birth Defects Prevention Study 1997–2011 reported genitourinary tract infections during the periconceptional period to be significantly associated with gastroschisis (OR, 1.5; 95% CI, 1.3–1.9) [ 28 ].…”

Section: Epidemiologymentioning

confidence: 99%

Gastroschisis: A State-of-the-Art Review

2020

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Gastroschisis, the most common type of abdominal wall defect, has seen a steady increase in its prevalence over the past several decades. It is identified, both prenatally and postnatally, by the location of the defect, most often to the right of a normally-inserted umbilical cord. It disproportionately affects young mothers, and appears to be associated with environmental factors. However, the contribution of genetic factors to the overall risk remains unknown. While approximately 10% of infants with gastroschisis have intestinal atresia, extraintestinal anomalies are rare. Prenatal ultrasound scans are useful for early diagnosis and identification of features that predict a high likelihood of associated bowel atresia. The timing and mode of delivery for mothers with fetuses with gastroschisis have been somewhat controversial, but there is no convincing evidence to support routine preterm delivery or elective cesarean section in the absence of obstetric indications. Postnatal surgical management is dictated by the condition of the bowel and the abdominal domain. The surgical options include either primary reduction and closure or staged reduction with placement of a silo followed by delayed closure. The overall prognosis for infants with gastroschisis, in terms of both survival as well as long-term outcomes, is excellent. However, the management and outcomes of a subset of infants with complex gastroschisis, especially those who develop short bowel syndrome (SBS), remains challenging. Future research should be directed towards identification of epidemiological factors contributing to its rising incidence, improvement in the management of SBS, and obstetric/fetal interventions to minimize intestinal damage.

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“…The finding of zero cases of GS in the HB is not too surprising since the major risk factors such as low maternal age (less than 20 years), smoking, alcohol, illicit drug use, underweight (BMI less than 18), poor nutrition, genital infections (Baer et al, 2015; Bugge et al, 2017; Feldkamp et al, 2019; Rasmussen & Frías, 2008; Skarsgard et al, 2015) and opioid exposure (Short et al, 2019) are probably low in this population due to cultural, religious, and lifestyle patterns of the HB. Marriages do not occur until adult baptism has taken place, generally between the ages of 19 and 22 (Hostetler, 1985).…”

Section: Discussionmentioning

confidence: 99%

Prevalence rates study of selected isolatednon‐Mendeliancongenital anomalies in the Hutterite population of Alberta, 1980–2016

Lowry

Bedard

Crawford

et al. 2020

American J of Med Genetics Pt A

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A study of the prevalence rates for selected isolated non-Mendelian congenital anomalies in the Hutterite Brethren of Alberta, Canada was undertaken to further examine longitudinal data in this isolated community that was last reported in 1985 (Lowry et al., 1985), although there are numerous publications on recessive disorders (Boycott et al., 2008; Triggs-Raine et al., 2016). Cases were ascertained from the Alberta Congenital Anomaly Surveillance System for the years 1997-2016. Since our initial results showed some surprising findings in the Hutterite Brethren, such as zero cases of spina bifida, cleft lip and palate, gastroschisis, and omphalocele, and a significant excess of cases with hypospadias, we extended the study to prior years (1980-1996) for selected anomalies. For the extended study period (1980-2016), there was a significant increased prevalence of hypospadias, tetralogy of Fallot and tricuspid atresia in the Hutterite population, and although not statistically significant, zero cases of cleft lip with cleft palate, gastroschisis and omphalocele were confirmed. Further research is needed to determine the precise effects of rural environmental exposures, lifestyle factors, and genetic associations for selected multifactorial congenital anomalies.

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Risk of gastroschisis with maternal genitourinary infections: the US National birth defects prevention study 1997–2011

Cited by 21 publications

References 60 publications

Birth prevalence of congenital anomalies in the City of Buenos Aires, Argentina, according to socioeconomic level

Birth prevalence of congenital anomalies in the City of Buenos Aires, Argentina, according to socioeconomic level

Gastroschisis: A State-of-the-Art Review

Prevalence rates study of selected isolatednon‐Mendeliancongenital anomalies in the Hutterite population of Alberta, 1980–2016

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