Risk of febrile convulsions after MMRV vaccination in comparison to MMR or MMR+V vaccination

Safety of Measles-Containing Vaccines in 1-Year-Old Children

“…This study further confirmed (by using previously unanalyzed data) that MMRV and MMR + V are both associated with fever and seizure 7 to 10 days after vaccination, and validated our previous findings and those of others that MMRV versus MMR + V is associated with an excess risk of seizures 7 to 10 days after vaccination. 19,20,[34][35][36] This study replicated previously reported safety findings, which provides additional reassurance that assessing the 7 main outcomes with this approach was reasonable.…”

Immunogenicity and safety of a combined measles, mumps, rubella and varicella live vaccine (ProQuad®) administered concomitantly with a booster dose of a hexavalent vaccine in 12–23-month-old infants

“…the first but not the second doses of MMRV combined vaccines compared with separate MMR and varicella vaccines [24][25][26][27]. The data on a first dose of ProQuad ® observed in this study are still applicable with the hexavalent booster vaccine administered concomitantly with a second dose of ProQuad ® later in life.…”

Measles–Mumps–Rubella–Varicella Combination Vaccine (ProQuad®): A Guide to Its Use in Children in the EU

“…Although the risk of febrile seizure at specified timepoints is increased after the first dose of ProQuad Ò compared with M-M-RVAXPRO Ò plus Varivax Ò , the risk for any individual is relatively low based on a pooled analysis of safety data from five trials in children aged 12-23 months receiving one (n = 3112) or two doses (n = 2780) of ProQuad Ò [24]. Postmarketing studies confirmed the increased risk of febrile seizures (one for every 2300-2700) after the first dose of a MMRV combined vaccine and suggested that it was a class effect for MMRV vaccines [5,[25][26][27][28][29]. No increased risk was observed after the second dose.…”