Risk of esophageal cancer following radiotherapy for Hodgkin lymphoma

Nordic Cancer Registries – an overview of their procedures and data comparability

“…Registration of subsequent primary tumors in patients with one tumor has been an important tool in numerous studies of shared risk factors of cancers (e.g., [27]) and late effects related to treatment of the first malignancy (e.g., [28]). In special instances, it would be important to assess the risk of second primary tumors in the same organ, e.g., in the study on risk of new breast cancer among women who took hormonal therapy after their first breast cancer [29].…”

Risk factors and molecular mechanisms of esophageal cancer: differences between the histologic subtype

“…Radiotherapy for thoracic diseases, such as breast cancer and Hodgkin's lymphoma, increases the risk of both ESCC and EAC. [21,22] The incidence of both ESCC and EAC increases with age. There is a strong male predominance with up to eight men/one woman for EAC and three men/one woman for ESCC.…”

Outcomes of Radiation-Associated Esophageal Squamous Cell Carcinoma: The MSKCC Experience

“…As described in the literature, ESCC-R was defined as development of esophageal squamous cell carcinoma within a field previously radiated for the treatment of breast, head and neck, lung, mediastinum, or esophagogastric disease with latency of ≥ 5 years from radiation exposure to esophageal cancer diagnosis. [7,9,11] Of 896 patients identified with esophageal squamous cell carcinoma that were eligible for inclusion, 69 patients met criteria for ESCC-R. (Figure 1) Data on previous cancer, previous radiation dose, and interval time from initiation radiation to diagnosis of esophageal cancer was abstracted from patient charts. Demographics, clinical staging and treatment selection were collected and compared between all patients with ESCC-R and ESCC.…”