Nordic Cancer Registries – an overview of their procedures and data comparability

Pukkala, Eero; Engholm, Gerda; Schmidt, Lise Kristine Højsgaard; Storm, Hans; Khan, S.; Lambe, Mats; Pettersson, David; Ólafsdóttir, Elínborg J; Tryggvadóttír, Laufey; Hakanen, Tiina; Malila, Nea; Virtanen, Anni; Johannesen, Tom Børge; Larønningen, Siri; Ursin, Giske

doi:10.1080/0284186x.2017.1407039

Cited by 244 publications

(335 citation statements)

References 31 publications

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“…22 The quality of data originates in part in the civil registration system, which is based on personal identity codes and multiple population-based registries, which make record linkage possible. 22 The quality of data originates in part in the civil registration system, which is based on personal identity codes and multiple population-based registries, which make record linkage possible.…”

Section: Discussionmentioning

confidence: 99%

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Suicides and deaths linked to risky health behavior in childhood cancer patients: A Nordic population‐based register study

Korhonen

Taskinen

Rantanen

et al. 2019

Cancer

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BACKGROUND: Childhood cancer survivors have been reported to be vulnerable to psychiatric morbidities and risky health behavior. Suicides, substance abuse, accidents, and violence as causes of death can be regarded as an extreme manifestation of risky health behavior. In the current study, the authors studied the risk of suicide and other risky health behavior-related deaths among childhood cancer patients in Denmark, Finland, and Sweden. METHODS: Using linkage between national cancer, population, and cause-of-death registries, the authors investigated the causes of death in 29,285 patients diagnosed with cancer before age 20 years between 1971 and 2009 compared with a cohort of 146,282 age-matched, sex-matched, and country-matched population comparisons. Rate ratios (RRs) with 95% CIs were estimated using Poisson regression models, adjusting for demographic factors. RESULTS:The overall risk of dying of a risky health behavior was found to be increased among childhood cancer patients (RR, 1.25; 95% CI, 1.06-1.47) when compared with population comparisons. The elevated risk was statistically significant among patients with central nervous system tumors (RR, 1.49; 95% CI, 1.08-2.05) and patients diagnosed at ages 5 to 9 years and 15 to 19 years (RR, 1.50 [95% CI, 1.01-2.24] and RR, 1.31 [95% CI, 1.03-1.67], respectively). The overall risk of suicide was found to be increased (RR, 1.37; 95% CI, 1.02-1.83), and statistically significantly so when patients were diagnosed between ages 15 and 19 years (RR, 1.61; 95% CI, 1.09-2.39). CONCLUSIONS: Childhood cancer patients appear to have an increased risk of risky health behavior-related causes of death compared with the general population. The results of the current study suggest the importance of integrating psychosocial support into the follow-up care of these individuals. Cancer 2019;125:3631-3638.

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Section: Discussionmentioning

confidence: 99%

“…22 According to a recent report by the United Nations, Nordic populations have been ranked the happiest worldwide. The strengths of the current study included the 3-country population-based setting with all patients included, a cohort that therefore was free of selection or participation bias.…”

Section: Discussionmentioning

confidence: 99%

Suicides and deaths linked to risky health behavior in childhood cancer patients: A Nordic population‐based register study

Korhonen

Taskinen

Rantanen

et al. 2019

Cancer

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“…The Swedish Family‐Cancer Database includes data on the Swedish population collated in family and is linked to the Swedish Cancer Registry, which was founded in 1958 and covers the entire population with more than 2 million cancers . The registry is based on compulsory cancer notifications made by clinicians and pathologists/cytologists . Since the mid‐1980s, there are six regional registries associated with the oncological centers in each medical region of Sweden where the registration, coding and major check‐up and correction work is performed.…”

Section: Methodsmentioning

confidence: 99%

Second primary cancers in non‐Hodgkin lymphoma: Family history and survival

Chattopadhyay

Zheng

Sud

et al. 2019

Intl Journal of Cancer

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Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses and family history of cancer may be a risk factor for SPCs. Using the Swedish Family‐Cancer Database on non‐Hodgkin lymphoma (NHL), we assessed the influence of family history on risk of SPCs and of SPCs on survival. NHL patients were identified from the years 1958 to 2015 and generalized Poisson models were used to calculate relative risks (RRs) for SPCs and familial SPCs. Among 14,393 NHL patients, a total of 1,866 (13.0%) were diagnosed with SPC. Familial risk of nine particular cancers was associated with risks of these cancers as SPCs, with twofold to fivefold increase in RRs. At the end of a 25‐year follow‐up period, the survival probability for persons with SPC was only 20% of that for patients without SPC; the hazard ratio for SPC was 1.59 (95% CI: 1.46–1.72). Survival could be predicted by the prognostic groups based on first cancers and HRs increase systematically with worse prognosis yielding a trend of p = 4.6 × 10−5. SPCs had deleterious consequences for survival in NHL patients. Family history was associated with increasing numbers of SPCs. Prevention of SPCs and their early detection is an important target in the overall strategy to improve survival in NHL patients. Counseling for avoidance of risk factors and targeted screening based on family history are feasible steps in risk reduction.

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“…The Swedish Family‐Cancer Database includes the whole Swedish population organized in families and linked to the national Cancer Registry with more than 2 million cancers registered since 1958 . The registry is based on compulsory cancer notifications from clinicians and pathologists/cytologists . All registered NHL cases were histologically verified.…”

Section: Methodsmentioning

confidence: 99%

Second primary cancers in non‐Hodgkin lymphoma: Bidirectional analyses suggesting role for immune dysfunction

Chattopadhyay

Sud

Zheng

et al. 2018

Intl Journal of Cancer

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Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses. It is unlikely that prior therapy is solely responsible for SPC risk. To investigate risk of SPC after diagnosis of non‐Hodgkin lymphoma (NHL) and 10 of its subtypes we conducted a novel bidirectional analysis, SPCs after NHL and NHL as SPC. Using the Swedish Family‐Cancer Database, we identified 19,833 individuals with primary NHL diagnosed between 1993 and 2015. We calculated relative risks (RRs) of SPCs in NHL survivors and, for bi‐directional analysis, risk of NHL as SPC. The overall RRs were significantly bidirectionally increased for NHL and 7 cancers. After diagnosis of NHL risks were increased for upper aerodigestive tract (RR = 1.96), colorectal (1.35), kidney (3.10), bladder (1.54) and squamous cell skin cancer (SCC) (4.12), melanoma (1.98) and Hodgkin lymphoma (9.38). The concordance between RRs for each bidirectional association between NHL and 31 different cancers was highly significant (r = 0.86, p < 0.0001). Melanoma was bidirectionally associated with all 10 subtypes of NHL. The observed bidirectional associations between NHL and cancer suggest that therapy‐related carcinogenic mechanisms cannot solely explain the findings. Considering that skin SCC and melanoma are usually treated by surgery and that these cancers and NHL are most responsive of any cancer to immune suppression, the consistent bidirectional results provide population‐level evidence that immune suppressed state is a key underlying mechanism in the context of SPCs. Furthermore, the quantified risks for NHL subtypes have direct clinical application in the management of NHL patients.

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Nordic Cancer Registries – an overview of their procedures and data comparability

Cited by 244 publications

References 31 publications

Suicides and deaths linked to risky health behavior in childhood cancer patients: A Nordic population‐based register study

Suicides and deaths linked to risky health behavior in childhood cancer patients: A Nordic population‐based register study

Second primary cancers in non‐Hodgkin lymphoma: Family history and survival

Second primary cancers in non‐Hodgkin lymphoma: Bidirectional analyses suggesting role for immune dysfunction

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