Risk of clinically relevant hyperglycemia with metoprolol compared to carvedilol in older adults with heart failure and diabetes

Strom, Brian L.; Kobylarz, Fred; Horton, Daniel B.; Gerhard, Tobias; Tseng, Chin‐Lin; Dejanovic, Ilja; Nyandege, Abner; Setoguchi, Soko

doi:10.1002/pds.5303

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…This approach provides a simple, yet effective, strategy to deliver CAR for the management of symptomatic chronic heart failure. It has been reported that CAR is frequently prescribed to multimorbid individuals with heart failure and these patients are most prevalent within the geriatric patient group (7,8). Since approximately 15-20% of geriatric patients typically suffer dysphagia, the use of MAPs to deliver CAR transdermally is a great advantage, circumventing the need for an oral-based delivery system and the drawbacks that accompany it (9).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Permeation Studies on Carvedilol Containing Dissolving Microarray Patches Quantified Using a Rapid and Simple HPLC-UV Analytical Method

et al. 2022

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Analytical method validation is a vital element of drug formulation and delivery studies. Here, high-performance liquid chromatography in conjunction with UV detection (HPLC-UV) has been used to produce a straightforward, quick, yet sensitive analytical approach to quantify carvedilol (CAR). A C18 column was used to isolate the analyte from the mixture by isocratic elution with a mobile phase comprising a mixture of 0.1% v/v trifluoroacetic acid in water and acetonitrile in a ratio of 65:35 v/v at a flow rate of 0.6 mL min−1. Linearity was observed for CAR concentrations within the range of 1.5–50 μg mL−1 (R2 = 0.999) in phosphate buffer saline and within the range of 0.2–6.2 μg mL−1 (R2 = 0.9999) in methanol. The International Council on Harmonization (ICH) requirements were followed throughout the validation of the isocratic approach, rendering it specific, accurate, and precise. Moreover, robustness tests indicated that the method remained selective and specific despite small deliberate changes to environmental and operational factors. An efficient extraction procedure was also developed to extract and quantify CAR from excised neonatal porcine skin, resulting in recovery rates ranging from 95 to 97%. The methods reported here have been successfully utilised to evaluate CAR permeation, both transdermally and intradermally following application of a dissolving microarray patch (MAP) to excised neonatal porcine skin. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

In Vitro Permeation Studies on Carvedilol Containing Dissolving Microarray Patches Quantified Using a Rapid and Simple HPLC-UV Analytical Method

et al. 2022

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Side effects of beta adrenergic antagonists and antianginal drugs

Stever

Ali

Chambers

et al. 2022

Side Effects of Drugs Annual

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Air Pollution and Cardiovascular and Thromboembolic Events in Older Adults With High-Risk Conditions

Nethery¹,

Josey²,

Gandhi³

et al. 2023

American Journal of Epidemiology

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Little epidemiologic research has focused on pollution-related risks in medically vulnerable or marginalized groups. Using a nationwide 50% random sample of 2008-2016 Medicare Part D-eligible Fee-for-Service participants in the US, we identified a cohort with high-risk conditions for cardiovascular and thromboembolic events (CTE) and linked individuals with seasonal average zip code level concentrations of fine particulate matter (PM2.5). We assessed the relationship between seasonal PM2.5 exposure and hospitalization for each of seven CTE-related causes using history-adjusted marginal structural models adjusted for individual demographic and neighborhood socio-economic variables as well as baseline comorbidities, health behaviors, and health service measures. We examined effect modification across geographically- and demographically-defined subgroups. The cohort included 1,934,453 individuals with high-risk conditions (mean age 77, 60% female, 87% white). A 1 μg/m3 increase in PM2.5 exposure was significantly associated with increased risk of six out of seven CTE hospitalization types. Strong increases were observed for transient ischemic attack (HR: 1.039 (1.034,1.044)), venous thromboembolism (HR: 1.031 (1.027,1.035)), and heart failure (HR: 1.019 (1.017,1.020)). Asian Americans were found to be particularly susceptible to thromboembolic effects of PM2.5 (venous thromboembolism HR: 1.063 (1.021,1.106)), while Native Americans were most vulnerable to cerebrovascular effects (transient ischemic attack HR: 1.093 (1.030,1.161)).

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Risk of clinically relevant hyperglycemia with metoprolol compared to carvedilol in older adults with heart failure and diabetes

Cited by 3 publications

References 34 publications

In Vitro Permeation Studies on Carvedilol Containing Dissolving Microarray Patches Quantified Using a Rapid and Simple HPLC-UV Analytical Method

In Vitro Permeation Studies on Carvedilol Containing Dissolving Microarray Patches Quantified Using a Rapid and Simple HPLC-UV Analytical Method

Side effects of beta adrenergic antagonists and antianginal drugs

Air Pollution and Cardiovascular and Thromboembolic Events in Older Adults With High-Risk Conditions

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