Risk of Childhood Cancer by Maternal Birthplace

Heck, Julia E.; Park, Andrew S.; Contreras, Zuelma A; Davidson, Tom B.; Hoggatt, Katherine J.; Cockburn, Myles; Ritz, Beate

doi:10.1001/jamapediatrics.2016.0097

Cited by 22 publications

(15 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The distribution of cases by sex in this age group is similar to what is reported nationally [28]. Both teratomas and yolk sac tumors were more common among children of Asian/Pacific Islander descent, and yolk sac tumors were also seen more often among the children of foreign-born Hispanic mothers, as previously reported [29]. As a consequence, they were associated with risk factors more common in these demographic groups in California, including greater parity and less than 8 years of formal education, characteristics more common among foreign-born Hispanic parents, as well as fetopelvic disproportion, more commonly found in Asian mothers in California.…”

Section: Discussionsupporting

confidence: 86%

Risk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics

Hall

Ritz

Cockburn

et al. 2017

Cancer Epidemiology

Self Cite

View full text Add to dashboard Cite

Background Childhood germ cell tumors (GCTs) are a rare assortment of neoplasms, with mostly unknown etiology, that are believed to originate very early in life. Few studies have examined risk factors by histologic subtype, despite evidence of different risk profiles. Materials and Methods In this population-based case-control study, 451 childhood malignant GCT cases ages 0–5 years were identified from the California Cancer Registry. Differentiating between common histologic subtypes, we identified 181 yolk sac tumors, 216 teratomas, and 54 rarer subtypes. Cases were linked to their birth certificates and 271,381 controls, frequency matched by birth year, were randomly selected from California birthrolls to investigate the contributions of demographic, gestational, and pregnancy factors using unconditional logistic regression analysis. Results Compared to non-Hispanic whites, Asian/Pacific Islander children were at an increased risk for developing GCTs (odds ratio [OR]=1.94; 95% confidence interval [CI]=1.47, 2.56). Among pregnancy complications and procedures, yolk sac tumors were positively associated with the presence of fetopelvic disproportion (OR=2.97; 95% CI=1.55, 5.68), while teratomas were strongly associated with polyhydramnios or oligohydramnios (OR=14.76; 95% CI=7.21, 30.19) and the presence of an ear, face, or neck anomaly at birth (OR=93.70; 95% CI=42.14, 208.82). Conclusions Malignant yolk sac tumors and malignant teratomas exhibited distinct demographic and gestational characteristics; additionally, complications in pregnancy and labor may be brought on by specific histologic subtypes.

show abstract

Section: Discussionsupporting

confidence: 86%

Risk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics

Hall

Ritz

Cockburn

et al. 2017

Cancer Epidemiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…These disparities may be indicative of unique underlying gene‐environment interactions. For example, in a population‐based cohort in California, Heck et al 25 …”

Section: Discussionmentioning

confidence: 99%

Race, ethnicity, and socioeconomic differences in incidence of pediatric embryonal tumors in the United States

Geris

Spector

2020

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Background The etiology of childhood cancers and its social patterning remains largely unknown. Accounting for socioeconomic status (SES) when exploring the association between race/ethnicity and cancer incidence is necessary to better understand such etiology. We aimed to investigate differences in the incidence of embryonal tumors (ETs) by SES and race/ethnicity in the United States using population‐based registries of the Surveillance, Epidemiology, and End Results (SEER) Program. Procedure Children with ETs aged 0‐19 years diagnosed between 2000 and 2015 were ascertained from the census tract‐level SEER database. SES was measured using a tract‐level composite index. Incidence rate ratios (IRRs) with 95% confidence intervals (CIs) by SES quintile and race/ethnicity were estimated using multivariable Poisson regression models. Results The majority of tumors had lower incidence among nonwhite children compared with non‐Hispanic (NH) white children, after controlling for SES. NH blacks had a higher incidence of Wilms tumor than NH whites (IRR: 1.26; 95% CI, 1.13‐1.39). There was an increasing linear trend (P = 0.0001) across increasing SES quintile for embryonal rhabdomyosarcoma after controlling for race/ethnicity. Effect modification by race/ethnicity of the relationship between SES and tumor incidence was observed for several groups. Hispanics had a significant, linear trend (P = 0.0005) in the incidence of Wilms tumor, while Asian/Pacific Islanders experienced a significant inverse trend (P = 0.0002). Conclusions Results from this study suggest differences in the incidence of several ETs by race/ethnicity and that these differences may be modified by SES. Investigation of potential risk factors that are socially patterned is warranted.

show abstract

“…This was previously observed in a study from the United States and was explained by genetic susceptibility, lower prevalences of smoking and obesity among immigrant mothers, different rates of exposure to infections in early life, and migration selectivity (mothers who migrate are healthier than those who remain behind, and parents whose children are diagnosed with cancer are unlikely to migrate from their country). 41,42 This study provides important and unique data on the relationship between parental education and cancer mortality in children, adolescents, and young adults in Italy. The large number of events collected during the follow-up permitted a precise quantification of risks as well as a description of risk functions by age and parental education.…”

Section: Discussionmentioning

confidence: 99%

Parental education and cancer mortality in children, adolescents, and young adults: A case‐cohort study within the 2011 Italian census cohort

Alicandro

Bertuccio

Sebastiani

et al. 2020

Cancer

View full text Add to dashboard Cite

BACKGROUND: Progress in the treatment of juvenile cancers has led to remarkable improvements in survival. However, not all families have the resources to cope with the burden that such diseases require. This study was aimed at evaluating the association between parental education and cancer mortality in children, adolescents, and young adults. METHODS: This was a case-cohort study based on 1889 cancer cases and 108,387 noncases sampled from the 2011 Italian census cohort of 10,964,837 individuals younger than 20 years and followed for 6 years. Mortality rate ratios (MRRs) were estimated for individuals with parents with high and intermediate levels of education (International Standard Classification of Education [ISCED] levels 5-8 and 3-4, respectively) in comparison with individuals with less educated parents (ISCED levels < 3) through multiple Poisson regression models. RESULTS: Over the follow-up, 684, 858, and 347 cancer cases with parents with the lowest, intermediate, and highest levels of education, respectively, were registered. In comparison with the individuals with parents with the lowest level of education, the MRR from all neoplasms was 0.92 (95% confidence interval [CI], 0.83-1.03) for those with parents with an intermediate level of education and 0.83 (95% CI, 0.72-0.95) for those with parents with the highest level of education. The MRRs from all neoplasms for individuals with parents with the highest level of education were 0.88 (95% CI, 0.69-1.11) among children, 0.87 (95% CI, 0.70-1.06) among adolescents, and 0.64 (95% CI, 0.50-0.83) among young adults. CONCLUSIONS: Children, adolescents, and young adults with highly educated parents have reduced mortality from cancer. This calls for further efforts to optimize treatment for children of less educated parents. Cancer 2020;126:4753-4760.

show abstract

Risk of Childhood Cancer by Maternal Birthplace

Cited by 22 publications

References 34 publications

Risk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics

Risk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics

Race, ethnicity, and socioeconomic differences in incidence of pediatric embryonal tumors in the United States

Parental education and cancer mortality in children, adolescents, and young adults: A case‐cohort study within the 2011 Italian census cohort

Contact Info

Product

Resources

About