Risk of cancer in patients with epistaxis and haemoptysis

Ording, Anne Gulbech; Veres, Katalin; Farkas, Dóra Körmendiné; Adelborg, Kasper; Sørensen, Henrik Toft

doi:10.1038/bjc.2017.494

Cited by 5 publications

(7 citation statements)

References 27 publications

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“…Those local causes include neoplasms. In a large cohort of 9173 epistaxis reported by Ording et al [10] the standardized incidence ratio for all malignant neoplasms was 1.19. Glomangiopericytoma, the specific sinonasal tumor diagnosed in our case, is very rare and falls within the category of borderline and low-malignant-potential soft tissue tumors of the nose and paranasal sinus.…”

Section: Discussionmentioning

confidence: 88%

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Double jeopardy, glomangiopericytoma and Glanzmann thrombasthenia resulting in recurrent epistaxis: a case report

Hammami,

Fath,

Debry

et al. 2023

Blood Coagulation &Amp; Fibrinolysis

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Glanzmann thrombasthenia is a rare bleeding disorder induced by inherited defects of the platelet membrane αIIbβ3 glycoprotein. Glomangiopericytoma, on the other hand, is a very rare sinonasal tumor demonstrating a perivascular myoid phenotype. We herein report the first described case in the literature of Glanzmann thrombasthenia and glomangiopericytoma. The patient is a 40-year-old man diagnosed with type 1 Glanzmann thrombasthenia who presented with repetitive and profuse posterior epistaxis initially managed with platelet transfusions and recombinant activated factor VII (rFVIIa). Due to the unresolved epistaxis, nasal endoscopy was performed revealing a vascularized tumor. Subsequently, a sphenopalatine artery embolization followed by a surgical excision of the tumor was performed. The pathology report diagnosis of the tumor was glomangiopericytoma. This case sheds the lights on a very rare cause of epistaxis in a patient with Glanzmann thrombasthenia, with a challenging multidisciplinary management. A local cause of epistaxis should always be considered even in case of a diagnosed bleeding disorder, especially when the bleeding is recurrent.

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Section: Discussionmentioning

confidence: 88%

“…Those local causes include neoplasms. In a large cohort of 9173 epistaxis reported by Ording et al [10] the standardized incidence ratio for all malignant neoplasms was 1.19.…”

Section: Discussionmentioning

confidence: 99%

Double jeopardy, glomangiopericytoma and Glanzmann thrombasthenia resulting in recurrent epistaxis: a case report

Hammami,

Fath,

Debry

et al. 2023

Blood Coagulation &Amp; Fibrinolysis

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“…Using the DCR, we ascertained incident diagnoses of cancer. We investigated the long-term risk of any cancer; haematological, immune-related, alcohol and smoking-related, obesity-related cancers (35)(36)(37) and cancers at multiple specific sites, focusing specifically on breast, cervical, ovarian and fallopian tube, and uterine cancer (Table 1 in the electronic supplementary material).…”

Section: Cancer Outcomesmentioning

confidence: 99%

“…Using the DCR, we ascertained incident diagnoses of cancer. We investigated the long-term risk of any cancer; cancers at specific anatomic sites, focusing on breast, cervical, ovarian and fallopian tube, and uterine cancer, and cancers grouped as hormone-related, haematological, immune-related, smoking or alcohol-related, obesity-related, and cancers of neurological origin, as previously described (42)(43)(44)(Table 1 in the electronic supplementary material).…”

Section: Cancer Outcomesmentioning

confidence: 99%

Association between having a pregnancy complicated by vaginal bleeding and risk of cancer

Dudukina

Horváth‐Puhó

Sørensen

et al. 2022

Preprint

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Objective: To investigate an association of vaginal bleeding-affected deliveries with the long-term risk of cancer as compared with vaginal bleeding-unaffected deliveries and pregnancies ending in a termination or miscarriage. Design: Registry-based cohort study in Denmark, 1995-2017. Setting: Danish health and administrative registries. Participants: Deliveries (N=37,085) affected by vaginal bleeding (VB) within 20 gestational weeks among 35,517 women, VB-unaffected deliveries (N=1,362,760) among 783,020 women, pregnancies ending in a termination (N=324,395) among 239,729 women or miscarriage (N=137,040) among 121,303 women. Main outcome measures: Incidence rates (IR) per 10,000 person-years and cumulative incidence of cancer at the end of up to 24 years of follow-up, hazard ratios (HR) with 95% confidence intervals (CIs) adjusted for age, calendar year, reproductive history, history of chronic conditions, medication use, and socioeconomic factors using Cox proportional hazards regression. Results: We observed 1,725 cancer events (IR=32.1, 95% CI: 30.6-33.6) following VB-affected deliveries, 52,620 events (IR=31.5, 95% CI: 31.2-31.7) following VB-unaffected deliveries, 12,925 events (IR=30.1, 95% CI: 29.6-30.6) following a termination and 6,080 events (IR=34.3, 95% CI: 33.4-35.1) following a miscarriage. We found no association between VB and any cancer in comparison with VB-unaffected deliveries (HR=0.98, 95% CI: 0.93-1.03), terminations (HR=1.00, 95% CI: 0.94-1.06) and miscarriages (HR=1.04, 95% CI: 0.94-1.14). Specifically, there was no increase in relative risk of breast (HR=0.94, 95% CI: 0.86-1.03), cervical (0.94, 0.77-1.14), ovarian and fallopian tube (1.16, 0.81-1.66), uterine cancer (0.78, 0.46-1.33) and other site-specific cancers across all comparisons and in sensitivity analyses. Conclusions: Having a VB-affected pregnancy ending in a delivery was not associated with an increased risk of cancer in women in comparison with having a VB-unaffected pregnancy ending in a delivery, termination or miscarriage.

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“…Causes of hemoptysis include malignancy, pulmonary embolism and other vascular causes, infection, trauma, inflammation, and bronchiectasis. 20 Coughing up bright red blood or blood clots (raktau mukham) can be seen in carcinoma of the lung, tuberculosis (sleshma parikshaya?) and pulmonary embolism.…”

Section: Exploration Of the Contents Of Gomaya Churneeyammentioning

confidence: 99%

Gomaya churneeyam of bhela indriya sthana - an explorative study

Mamidi¹,

Gupta²

2021

IJCAM

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End-of-life stages; 'Gomaya churneeyam' is the 9th chapter of 'Bhela indriya sthana' which consists of 21 verses. This chapter deals with some arishta lakshanas which denotes an imminent death. 3,4 Previous works conducted on 'Charaka indriya sthana' [5][6][7][8][9][10][11][12][13][14][15][16][17][18] and 'Bhela indriya sthana' 19 have established their clinical and prognostic significance. The contents of 'gomaya churneeyam' are unique and needs further in-depth exploration. The present is aimed to evaluate the contents of 'gomaya churneeyam adhyaya' in scientific terms. Studies on 'gomaya churneeyam adhyaya' of 'Bhela indriya sthana' have been lacking and the present study is planned to explore the contents of this chapter in terms of its prognostic significance. Review methodologyA literature search has been undertaken. Both 'Google' and 'Google scholar' databases have been used for search. Full text

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Risk of cancer in patients with epistaxis and haemoptysis

Abstract: This corrects the article DOI: 10.1038/bjc.2017.85.

Cited by 5 publications

References 27 publications

Double jeopardy, glomangiopericytoma and Glanzmann thrombasthenia resulting in recurrent epistaxis: a case report

Double jeopardy, glomangiopericytoma and Glanzmann thrombasthenia resulting in recurrent epistaxis: a case report

Association between having a pregnancy complicated by vaginal bleeding and risk of cancer

Gomaya churneeyam of bhela indriya sthana - an explorative study

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