Risk of bladder cancer in male Japanese workers exposed to ortho-toluidine and other aromatic amines

Nakano, Makiko; Shinagawa, Takafumi; Eitaki, Yoko; Omae, Kazuyuki; Takeuchi, Ayano; Iwasawa, Satoko; Fukai, Kota; Yoshioka, Noriyuki; Tanaka, Shigeru; Koda, Shigeki; Sobue, Tomotaka; Takebayashi, Toru

doi:10.1007/s00420-021-01658-2

Cited by 5 publications

(6 citation statements)

References 20 publications

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“…Aromatic amines are also used in the manufacturing of products such as hair dyes, paints, fungicides, metals and plastics. In addition, these substances are present in cigarette smoke, motor vehicle exhaust or drinking water contaminants [34]. Research also confirms that exposure in the aluminum production industry causes BCa.…”

Section: Occupational Exposurementioning

confidence: 67%

“…Majority of the studies are cohort ones, but there are also case-control studies carried out all over the world. The research has focused primarily on assessing the risk of developing BCa [31][32][33][34][35][36], but also overall survival rates [37], overall incidence [38], mortality odds ratio [32,39,40] and lifetime prevalence [41,42]. Most of the studies have found an increased risk of developing BCa among exposed workers.…”

Section: Occupational Exposurementioning

confidence: 99%

“…asbestos Italy [32] Lumber, wood products, printing and allied industries, petroleum and coal products, fabricated metal products, electrical machinery, equipment and supplies, information and communication electronics diverse carcinogens Japan [36] Professional and managerial, clerical, sales and service, agriculture, forestry, and fishery, transportation (including machine operation workers), construction and mining, manufacturing, (e.g., homemakers, students, unemployed, miscellaneous) diverse carcinogens Japan [37] Factory manufacturing organic dye/pigment intermediates aromatic amines: ortho-toluidine, aniline, para-toluidine, ortho-anisidine, 2,4-xylidine, ortho-chloroaniline Japan [34] Road transportation workers, motor vehicle engine exhaust, traffic exhaust, housework detergents, cleaners, bleaches, oil fumes during frying, traffic air pollution Korea [102] Maritime workers -seafarers and fishermen diesel exhaust, asbestos, polycyclic aromatic hydrocarbons, ultraviolet radia tion Nordic countries [38] Textile industry cotton dust, caustic soda, acetic acid, hydrogen peroxide, surfactants, formaldehyde, azo dyes, phthalates, perfluorinated compounds Turkey [44] Welding, making cement lubricating/coolant oils, soldering/brazing, degreasing, fumes from quenching/forging or cooling United Kingdom [103] Firefighters polycyclic aromatic hydrocarbons, polychlorinated biphenyls, formaldehyde, benzene, 1,3-butadiene, asbestos, diesel exhaust, circadian disruption from shift work USA [39] Aluminum smelting workers airborne metal dusts, asbestos, polycyclic aromatic hydrocarbons, silica, chemical vapors USA [40] Boat builders cumulative styrene USA [104] Benzidine manufacturing plant benzidine, dichlorobenzidine USA [35] Chemical manufacturing plant aromatic amine: ortho-toluidine USA [42] Automobile manufacturing workers metalworking fluids USA [105] Heavy truck drivers, tractor-trailer drivers, bus drivers, engine mechanics, repairers, equipment operators respirable elemental carbon USA and Spain [31] exposure to carcinogenic effective azo dyes and heavy metal-containing substances [45]. It is not only work in an industry that carries the risk of cancer.…”

Section: Occupational Exposurementioning

confidence: 99%

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Androgen receptor modulation and bladder cancer prevention – a short review

Wieczorek¹,

Farooqı²,

Reszka³

2022

Med Pr

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The prevalence of bladder cancer (BCa) is 4 times higher in men as compared to women, and gender differences have been the focus of attention for few years. Androgen receptor (AR) may be a putative explanation for gender differences. It may also be related to unfavourable BCa progression and development because of the increased androgen sensitivity of urothelium to carcinogens. Moreover, cigarette smoking and occupational exposure to carcinogens have been reported to play contributory roles with the highest attributable risk of BCa. In this review, the authors attempt to summarize the seminal research works that synthesized current understanding of the central role of AR in the negative regulation of carcinogen detoxification activity in BCa. In particular, the authors discuss the regulatory effects of 3,3'-diindolylmethane on AR gene transcription through microRNA as its suggested effect on the prevention of BCa. Moreover, to show the still existing problem of occupational exposure and BCa incidence, the authors review recent studies in this area. Based on the rapidly accumulating scientific evidence, it seems pragmatic that androgen/AR-mediated interference in the detoxification mechanism may be inhibited by phytochemicals. Therefore, collectively, nutrition has a key role as gene-nutrient interactions are important contributors to BCa prevention, also through epigenetic modifications. Here, the authors have derived suggestions for future research. Med Pr. 2022;73(2)

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Section: Occupational Exposurementioning

confidence: 67%

Section: Occupational Exposurementioning

confidence: 99%

Section: Occupational Exposurementioning

confidence: 99%

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Androgen receptor modulation and bladder cancer prevention – a short review

Wieczorek¹,

Farooqı²,

Reszka³

2022

Med Pr

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“…The pronounced carcinogenicity of o-toluidine has been reported [10,11] Materials listing of all examined publications) by most researchers in electrochemistry and corrosion protection. This report provides first an overview on the carcinogenicity of o-toluidine and associated health risks, discusses representative electrochemical studies, and suggests possibilities to avoid this risk by e.g., using other compounds or at least m-or p-toluidine.…”

Section: Introductionmentioning

confidence: 93%

o-Toluidine in electrochemistry – an overview

Weber

Richter

Holze

2022

J Solid State Electrochem

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The substituted aromatic amine o-toluidine (2-methylaniline, 1-amino-2-methylbenzene) is frequently encountered in electrochemical research as a soluble corrosion inhibitor dissolved in aqueous media used e.g., in cooling systems, as a homomonomer for formation of intrinsically conducting poly-o-toluidine and as a comonomer in formation of respective copolymers and their composites. The obtained polymers are suggested as corrosion protection coatings, as active materials in devices for electrochemical energy storage, but more frequently, they are examined as active components in electrochemical sensors.The significant and pronounced carcinogenicity of o-toluidine has hardly been addressed; presumably, most researchers are not even aware of this property. After a brief summary of the health risks and effects, the following overview presents typical examples of said studies and applications. If possible, substitutes with lower health risks are proposed, at least further studies enabling such replacement are suggested.

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“…Several occupational cancers that have occurred in Japan over the past decade were reportedly caused by chemicals that were not regulated at the time of the outbreak. 8 9 …”

Section: Introductionmentioning

confidence: 99%

Length of employment in workplaces handling hazardous chemicals and risk of cancer among Japanese men

et al. 2023

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ObjectivesIn Japan, the risk of developing cancer among workers employed in workplaces where chemical substances are handled is unclear. This study aimed to assess the association between cancer risk and employment in workplaces handling hazardous chemicals.MethodsThe Inpatient Clinico-Occupational Survey of the Rosai Hospital Group data of 120 278 male patients with incident cancer and 217 605 hospital controls matched for 5-year age group, hospital (34 hospitals) and year of admission (2005–2019) were analysed. Cancer risk in relation to lifetime employment in workplaces using regulated chemicals was assessed while controlling for age, region and year of diagnosis, smoking, alcohol consumption and occupation. Further analysis stratified by smoking history was performed to examine interaction effects.ResultsIn the longest group of employment in tertiles, ORs were increased for all cancers (OR=1.13; 95% CI: 1.07 to 1.19) and lung (OR=1.82; 95% CI: 1.56 to 2.13), oesophageal (OR=1.73; 95% CI: 1.18 to 2.55), pancreatic (OR=2.03; 95% CI: 1.40 to 2.94) and bladder (OR=1.40; 95% CI: 1.12 to 1.74) cancers. Employment of 1+ years was associated with risk for lung cancer; 11+ years for pancreatic and bladder cancers; and 21+ years for all cancers and oesophageal cancer. These positive relationships were particularly obvious among patients with a history of smoking; however, no significant interaction between smoking and length of employment was observed.ConclusionsThere is a high risk of cancer among workers, especially smokers, employed in workplaces handling regulated chemicals in Japan. Thus, future measures for chemical management in workplaces are needed to prevent avoidable cancers.

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Risk of bladder cancer in male Japanese workers exposed to ortho-toluidine and other aromatic amines

Cited by 5 publications

References 20 publications

Androgen receptor modulation and bladder cancer prevention – a short review

Androgen receptor modulation and bladder cancer prevention – a short review

o-Toluidine in electrochemistry – an overview

Length of employment in workplaces handling hazardous chemicals and risk of cancer among Japanese men

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