Androgen receptor modulation and bladder cancer prevention – a short review

Wieczorek, Edyta; Farooqı, Ammad Ahmad; Reszka, Edyta

doi:10.13075/mp.5893.01229

Cited by 2 publications

(2 citation statements)

References 90 publications

(124 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bladder cancer incidence is increasing nowadays due to occupational and environmental exposure. Exposure to heavy metal is reported to play contributory roles with increasing risk of BC [ 21 ]. Our study was conducted on 49 BC patient varying in their grades and stage in Urology and Nephrology Center, Mansoura University.…”

Section: Discussionmentioning

confidence: 99%

Does the Presence of Heavy Metals Influence the Gene Expression and Oxidative Stress in Bladder Cancer?

El-Agrody,

Abol-Enein,

Mortada

et al. 2023

Biol Trace Elem Res

View full text Add to dashboard Cite

Heavy metal toxicity is associated with cancer progression. Studies have reported the relation between some metal ions and bladder cancer (BC). Direct influence of such agents in bladder carcinogenesis is still needed. Total 49 BC patients were included in the study. Level of Pb, Cr, Hg and Cd, oxidative stress markers, and gene expression of Bcl-2, Bax, IL-6, AKT, and P38 genes were detected in cancer and non-cancerous tissues obtained from bladder cancer patients. Concentrations of Pb, Cr, and Cd were significantly elevated in cancer tissues than normal, while Hg level was significantly increased in normal tissue than cancer. MDA level was significantly higher and SOD activity was lower in the cancer tissues compared to non-cancerous. The expressions of Bcl-2, IL-6, AKT, and P38 were significantly increased in the cancer tissues than in normal tissues while Bax level was significantly increased in non-cancerous tissue than in cancer tissue. In cancer tissue, there were significant correlations between Cr level with expression of Bax, AKT, and P38 while Cd level was significantly correlate with Bax, IL-6, AKT, and P38expression. The correlation between Cr and Cd with the expression of Bax, IL-6, AKT, and P38 may indicate a carcinogenic role of these metals on progression of bladder cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Does the Presence of Heavy Metals Influence the Gene Expression and Oxidative Stress in Bladder Cancer?

El-Agrody,

Abol-Enein,

Mortada

et al. 2023

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…The initiation and progression of bladder cancer (BCa) may be tightly related to the androgen receptor (AR). 111 After analyzing BCa survival based on TCGA database, it was found that PD-L1 expression negatively correlated to survival in male BCa patients but not in female patients. Thus, AR has been speculated to regulate PD-L1 expression.…”

Section: Hsa_circ_0046523mentioning

confidence: 99%

Synergistic Immunoregulation: harnessing CircRNAs and PiRNAs to Amplify PD-1/PD-L1 Inhibition Therapy

Han,

Rao,

Zhou

et al. 2024

IJN

View full text Add to dashboard Cite

The utilization of PD-1/PD-L1 inhibitors marks a significant advancement in cancer therapy. However, the efficacy of monotherapy is still disappointing in a substantial subset of patients, necessitating the exploration of combinational strategies. Emerging from the promising results of the KEYNOTE-942 trial, RNA-based therapies, particularly circRNAs and piRNAs, have distinguished themselves as innovative sensitizers to immune checkpoint inhibitors (ICIs). These non-coding RNAs, notable for their stability and specificity, were once underrecognized but are now known for their crucial roles in regulating PD-L1 expression and bolstering anti-cancer immunity. Our manuscript offers a comprehensive analysis of selected circRNAs and piRNAs, elucidating their immunomodulatory effects and mechanisms, thus underscoring their potential as ICIs enhancers. In conjunction with the recent Nobel Prize-awarded advancements in mRNA vaccine technology, our review highlights the transformative implications of these findings for cancer treatment. We also discuss the prospects of circRNAs and piRNAs in future therapeutic applications and research. This study pioneers the synergistic application of circRNAs and piRNAs as novel sensitizers to augment PD-1/PD-L1 inhibition therapy, demonstrating their unique roles in regulating PD-L1 expression and modulating immune responses. Our findings offer a groundbreaking approach for enhancing the efficacy of cancer immunotherapy, opening new avenues for treatment strategies. This abstract aims to encapsulate the essence of our research and the burgeoning role of these non-coding RNAs in enhancing PD-1/ PD-L1 inhibition therapy, encouraging further investigation into this promising field.

show abstract

Androgen receptor modulation and bladder cancer prevention – a short review

Cited by 2 publications

References 90 publications

Does the Presence of Heavy Metals Influence the Gene Expression and Oxidative Stress in Bladder Cancer?

Does the Presence of Heavy Metals Influence the Gene Expression and Oxidative Stress in Bladder Cancer?

Synergistic Immunoregulation: harnessing CircRNAs and PiRNAs to Amplify PD-1/PD-L1 Inhibition Therapy

Contact Info

Product

Resources

About