Risk of Bias and Brand Explain the Observed Inconsistency in Trials on Glucosamine for Symptomatic Relief of Osteoarthritis: A Meta‐Analysis of Placebo‐Controlled Trials

Eriksen, Patrick René Gerhard; Bartels, Else Marie; Altman, Roy D.; Bliddal, Henning; Juhl, Carsten Bogh; Christensen, Robin

doi:10.1002/acr.22376

Cited by 71 publications

(65 citation statements)

References 59 publications

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“…Such results, as acknowledged by the Authors, had already been demonstrated in several previous and more comprehensive meta-analyses, including a dedicated Cochrane Review2 and a recent effort by Eriksen et al 3 specifically investigating possible differences in efficacy among glucosamine products. Indeed, glucosamine exists in different forms for pharmaceutical use, as extensively reviewed by Altman 4.…”

supporting

confidence: 59%

Different glucosamine sulfate products generate different outcomes on osteoarthritis symptoms

2017

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supporting

confidence: 59%

Different glucosamine sulfate products generate different outcomes on osteoarthritis symptoms

2017

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“…In addition, we found four systematic reviews [8, 12–14]. After title and abstract review, we obtained 29 articles related to glucosamine intervention.…”

Section: Resultsmentioning

confidence: 99%

Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis

et al. 2018

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Osteoarthritis (OA) of the knee is one of the main causes of mobility decline in the elderly. Non-surgical treatments such as administration of supplements to strengthen the joint cartilage matrix have become popular not only for pain relief but also for joint preservation. Glucosamine has been used in many countries based on the increasing evidence of its effectiveness for OA. Although there are many previous studies and systematic reviews, the findings vary and different conclusions have been drawn. We aimed to review recent randomized controlled trials on glucosamine for knee OA to reveal up-to-date findings about this supplement. We also performed a meta-analysis of some of the outcomes to overcome the unsolved bias in each study. Eighteen articles written between 2003 and 2016 were analyzed. Many used visual analogue scale (VAS) pain scores and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), which were assessed in our meta-analysis. We found a marginally favorable effect of glucosamine on VAS pain scores. The effect on knee function, as measured by the WOMAC, was small and not significant. A newly established knee OA scale, the Japanese Knee Osteoarthritis Measure (JKOM), is commonly used in Japan. Although the number of subjects was small, the JKOM meta-analysis indicated that glucosamine is superior to a placebo in alleviating knee OA symptoms. Given this, we concluded that glucosamine has the potential to alleviate knee OA pain. Further studies are needed to evaluate the effect of glucosamine on knee function and joint preservation, as well as to evaluate the combined effect with other components, such as chondroitin.

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“…Противопоказаниями являются повышенная чувствитель-ность к препарату, наличие фенилкетонурии при приеме порошка внутрь, так как он содержит аспартам. Пациентам с тяжелыми нарушениями проводимости сердца, острой сердечной недостаточностью, при указании в анамнезе на эпилептиформные судороги, детям в возрасте до 12 лет, при беременности и в период лактации, а также при повышенной чувствительности к лидокаину противопо-казан раствор для внутривенного введения, так как он содержит лидокаин [11,26,29].…”

Section: рисунок 2 роль глюкозамина в синтезе гиалуроновой кислоты рunclassified

“…В доступной нам научной литературе имеются выводы о значительной эффективно-сти оригинального кристаллического ГС в препарате ДОНА, который успеш-но применяется при первичном и вторичном ОА различной локализа-ции, спондилоартрозе, достоверно уменьшая суставную боль, обладая противовоспалительным действием. Хорошая переносимость препарата позволяет рекомендовать его для использования в реальной клиниче-ской практике, для улучшения каче-ства жизни пациентов с ОА [9,11,14,15,17,19,23,28,31]. Хотелось бы сослаться на личный опыт использования ДОНА -ориги-нального кристаллического ГС, кото-рый назначался для лечения ОА больным, находившимся на стацио-нарном лечении в ревматологиче-ском отделении НУЗ «Дорожная клиническая больница на станции Воронеж-1 ОАО «РЖД».…”

Section: оценивая эффективность дона следует отметить что кгс принаunclassified

Topical Issues of Osteoarthritis Treatment in Clinical Practice

Пешехонова¹,

Peshekhonov²,

Красюков³

2017

Med. sov.

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Risk of Bias and Brand Explain the Observed Inconsistency in Trials on Glucosamine for Symptomatic Relief of Osteoarthritis: A Meta‐Analysis of Placebo‐Controlled Trials

Cited by 71 publications

References 59 publications

Different glucosamine sulfate products generate different outcomes on osteoarthritis symptoms

Different glucosamine sulfate products generate different outcomes on osteoarthritis symptoms

Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis

Topical Issues of Osteoarthritis Treatment in Clinical Practice

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