Risk of Anaphylaxis After Vaccination of Children and Adolescents

Bohlke, Kari; Davis, Robert L.; Marcy, S. Michael; Braun, M. Miles; DeStefano, Frank; Black, Steven; Mullooly, John P.; Thompson, Robert S.

doi:10.1542/peds.112.4.815

Cited by 298 publications

(160 citation statements)

References 16 publications

(13 reference statements)

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“…We also did not identify any case of anaphylaxis that could be attributed to Td vaccine in this study. This is consistent with a prior study in the VSD of children up to 17 years of age who were vaccinated during 1991 through 1997, which identified no cases of anaphylaxis following 152,636 Td vaccinations [19]. …”

Section: Discussionsupporting

confidence: 92%

Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study

Jackson

Belongia

et al. 2009

BMC Infect Dis

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BackgroundLocal reactions are the most commonly reported adverse events following tetanus and diphtheria toxoid (Td) vaccine and the risk of local reactions may increase with number of prior Td vaccinations.MethodsTo estimate the risk of medically attended local reactions following Td vaccination in adolescents and young adults we conducted a six-year retrospective cohort study assessing 436,828 Td vaccinations given to persons 9 through 25 years of age in the Vaccine Safety Datalink population from 1999 through 2004.ResultsOverall, the estimated risk of a medically attended local reaction was 3.6 events per 10,000 Td vaccinations. The lowest risk (2.8 events per 10,000 vaccinations) was found in the 11 to 15 year old age group. In comparison with that group, the event risks were significantly higher in both the 9 to 10 and 21 to 25 year old age groups. The risk of a local reaction was significantly higher in persons who had received another tetanus and diphtheria toxoid containing vaccine (TDCV) in the previous five years (incidence rate ratio, 2.9; 95% confidence interval, 1.2 to 7.2). Twenty-eight percent of persons with a local reaction to Td vaccine were prescribed antibiotics.ConclusionMedically attended local reactions were uncommon following Td vaccination. The risk of those reactions varied by age and by prior receipt of TDCVs. These findings provide a point of reference for future evaluations of the safety profile of newer vaccines containing tetanus or diphtheria toxoid.

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Section: Discussionsupporting

confidence: 92%

Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study

Jackson

Belongia

et al. 2009

BMC Infect Dis

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“…14 Previous studies have suggested that anaphylaxis after MMR is rare (approximated at 1.5-1.8 events per 1 million doses). [11][12][13] In our study, neither of the 2 cases identified via electronic data as having anaphylaxis after MMRV was ultimately confirmed as acute anaphylaxis according to chart review. Analyses comparing MMRV with MMR + V did not identify any statistical difference; however, given the low frequency of anaphylaxis after administration of measles-containing vaccines, continued monitoring for anaphylaxis after these vaccines is warranted.…”

Section: Discussionmentioning

confidence: 99%

“…The measles-mumps-rubella (MMR) vaccine has been associated with several safety outcomes, including febrile seizures, [1][2][3][4] fever, [5][6][7] immune thrombocytopenia purpura (ITP), [8][9][10] anaphylaxis, [11][12][13] and possibly arthritis/arthralgia. 14 After licensure of the combination measles-mumpsrubella-varicella vaccine (MMRV), the Advisory Committee on Immunization Practices recommended in 2006 that it preferred use of the MMRV over separate MMR and varicella (V) vaccines for the 2 recommended doses at 12 to 15 months and 4 to 6 years of age.…”

mentioning

confidence: 99%

Safety of Measles-Containing Vaccines in 1-Year-Old Children

et al. 2015

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BACKGROUND AND OBJECTIVES: All measles-containing vaccines are associated with several types of adverse events, including seizure, fever, and immune thrombocytopenia purpura (ITP). Because the measles-mumps-rubellavaricella (MMRV) vaccine compared with the separate measles-mumps-rubella (MMR) and varicella (MMR + V) vaccine increases a toddler's risk for febrile seizures, we investigated whether MMRV is riskier than MMR + V and whether either vaccine elevates the risk for additional safety outcomes.

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“…1 The great variability found among total IgE values shows its low specificity for allergic diseases, in addition to its not being recommended for screening, once the increase in serum levels may occur in several clinical situations. 5 Frequency of positivity of specifi c IgE for dust mites (D. pteronyssinus) was higher in the control group (34.8%), suggesting that atopy is not related to anaphylaxis associated with vaccine.…”

Section: Resultsmentioning

confidence: 99%

Anafilaxia associada à vacina contra sarampo, caxumba e rubéola

Novadzki

Filho

2010

Rev. Saúde Pública

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A case-control study was carried out aiming to describe the cases and causes of anaphylaxis associated with the vaccine against measles, mumps and rubella. A total of 22 reported cases in children who showed mucocutaneous manifestations, during the Campanha Nacional de Vacinação (Brazilian Vaccination Campaign), conducted in the city of Curitiba, Southern Brazil, in 2004, were studied. In addition, 66 children, who were next to these cases and did not show a symptomatology after the vaccine was applied, were selected. Serum measurements of antibodies for vaccine antigens and total IgE, specifi c IgE antibody measurements for several allergens, and skin tests were performed. Vaccine response was adequate, specifi c IgE measurement and skin tests showed that potential allergens in vaccines and atopy were not associated with anaphylactic reactions. Skin tests with the vaccine and dextran were positive in the cases exclusively, suggesting sensitization to certain residual components of the vaccine and possible cross-reaction with dextran.

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Risk of Anaphylaxis After Vaccination of Children and Adolescents

Abstract: Patients and health care providers can be reassured that vaccine-associated anaphylaxis is a rare event. Nevertheless, providers should be prepared to provide immediate medical treatment should it occur.

Cited by 298 publications

References 16 publications

Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study

Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study

Safety of Measles-Containing Vaccines in 1-Year-Old Children

Anafilaxia associada à vacina contra sarampo, caxumba e rubéola

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