Risk of adult acute and chronic myeloid leukemia with cigarette smoking and cessation

Musselman, Jessica R.B.; Blair, Cindy K.; Cerhan, James R.; Nguyen, Phuong L.; Hirsch, Betsy A.; Ross, Julie A.

doi:10.1016/j.canep.2013.03.012

Cited by 53 publications

(56 citation statements)

References 32 publications

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“…In terms of lifestyle factors, cigarette smoking has been reported to increase the risk of myeloid leukemia, particularly AML (Musselman et al, 2013; Strom et al, 2012; Fircanis et al, 2014; Slager et al, 2014), while, in one study (Slager et al, 2014), an inverse association was found between current smoking and CLL. In the UK Million Women Study (Kroll et al, 2012), higher levels of smoking were associated with increased risk of MDS but not CLL.…”

Section: Introductionmentioning

confidence: 89%

Non-radiation risk factors for leukemia: A case-control study among chornobyl cleanup workers in Ukraine

Gudzenko

Hatch

Bazyka

et al. 2015

Environmental Research

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Background Occupational and environmental exposure to chemicals such as benzene has been linked to increased risk of leukemia. Cigarette smoking and alcohol consumption have also been found to affect leukemia risk. Previous analyses in a large cohort of Chornobyl clean-up workers in Ukraine found significant radiation-related increased risk for all leukemia types. We investigated the potential for additional effects of occupational and lifestyle factors on leukemia risk in this radiation-exposed cohort. Methods In a case-control study of chronic lymphocytic and other leukemias among Chornobyl cleanup workers, we collected data on a range of non-radiation exposures. We evaluated these other potential risk factors in analyses adjusting for estimated bone marrow radiation dose. We calculated Odds Ratios and 95% Confidence Intervals in relation to lifestyle factors and occupational hazards. Results After adjusting for radiation, we found no clear association of leukemia risk with smoking or alcohol but identified a two-fold elevated risk for non-CLL leukemia with occupational exposure to petroleum (OR=2.28; 95% Confidence Interval 1.13, 6.79). Risks were particularly high for myeloid leukemias. No associations with risk factors other than radiation were found for chronic lymphocytic leukemia. Conclusions These data – the first from a working population in Ukraine – add to evidence from several previous reports of excess leukemia morbidity in groups exposed environmentally or occupationally to petroleum or its products.

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Section: Introductionmentioning

confidence: 89%

Non-radiation risk factors for leukemia: A case-control study among chornobyl cleanup workers in Ukraine

Gudzenko

Hatch

Bazyka

et al. 2015

Environmental Research

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“…Ionising radiation is the only established risk factor, having been linked to CML in atomic bomb survivors [32]. Results from a recent population-based case-control study suggested a weak association between smoking and CML, but this has not yet been confirmed by other studies [33]. In a study based on the Swedish Cancer Registry and Multigenerational Registry, Bjorkholm et al found no significant familial aggregation of CML [13].…”

Section: Risk Factors For Developing CMLmentioning

confidence: 97%

Epidemiology of chronic myeloid leukaemia: an update

2015

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National and regional population-based registries are, provided diagnostic accuracy and full coverage of the target population, indispensible tools for epidemiological research. Chronic myeloid leukaemia (CML) registries with more comprehensive reporting may also provide complementary data on treatment outcome to those obtained from clinical trials. Reports from several European CML registries consistently show a crude annual incidence of 0.7-1.0/100,000, a median age at diagnosis of 57-60 years and a male/female ratio of 1.2-1.7. The incidence of CML has been stable over time. Worldwide, variations in the reported incidence of CML may be due to methodological issues, but a true difference between different geographical areas and/or ethnical subgroups cannot be excluded. The prevalence of CML is not well known but has been estimated to be 10-12/100,000 inhabitants with a steady increase due to the dramatic improvement in survival of these patients. In recent population-based studies, CML patients have an overall survival that is comparable to that shown in large clinical trials, though relative survival in patients >70 years is still decreased. The importance of socio-economic factors and health-care setting for outcome and the possible increased risk of secondary cancer in CML are areas of ongoing research.

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“…Only 0.11% (0.05%-0.26%) of inhaled benzene is metabolized to SPMA, which has a short half-life; mean ranges from 9 to 13 hours (39)(40)(41). Cigarette smoking is regarded as a source of benzene intake and an established risk factor for adult acute myelogenous leukemia (42)(43)(44)(45)(46)(47)(48)(49). Cigarette smokers have elevated excretion of SPMA, as much as ten times higher than non-smokers (50).…”

Section: Introductionmentioning

confidence: 99%

Benzene Uptake in Hookah Smokers and Non-smokers Attending Hookah Social Events: Regulatory Implications

Kassem

Jackson

Liles

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Benzene is a human hematotoxicant and a leukemogen that causes lymphohematopoietic cancers, especially acute myelogenous leukemia. We investigated uptake of benzene in hookah smokers and non-smokers attending hookah social events in naturalistic settings where hookah tobacco was smoked exclusively.Methods: We quantified S-phenylmercapturic acid (SPMA), a metabolite of benzene, in the urine of 105 hookah smokers and 103 non-smokers. Participants provided spot urine samples the morning of and the morning after attending an indoor hookah-only smoking social event at a hookah lounge or in a private home.Results: Urinary SPMA levels in hookah smokers increased significantly following a hookah social event (P < 0.001). This increase was 4.2 times higher after hookah lounge events (P < 0.001) and 1.9 times higher after home events (P ¼ 0.003). In non-smokers, urinary SPMA levels increased 2.6 times after hookah lounge events (P ¼ 0.055); however, similar urinary SPMA levels were detected before and after home events, possibly indicating chronic exposure to benzene (P ¼ 0.933).Conclusions: Our data provide the first evidence for uptake of benzene in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke at social events in private homes compared with their counterparts in hookah lounges. Hookah tobacco smoke is a source of benzene exposure, a risk factor for leukemia.Impact: Because there is no safe level of exposure to benzene, our results call for interventions to reduce or prevent hookah tobacco use, regulatory actions to limit hookah-related exposure to toxicants including benzene, initiate labeling of hookah-related products, and include hookah smoking in clean indoor air legislation. Cancer Epidemiol Biomarkers Prev; 23(12); 2793-809. Ó2014 AACR.

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Risk of adult acute and chronic myeloid leukemia with cigarette smoking and cessation

Cited by 53 publications

References 32 publications

Non-radiation risk factors for leukemia: A case-control study among chornobyl cleanup workers in Ukraine

Non-radiation risk factors for leukemia: A case-control study among chornobyl cleanup workers in Ukraine

Epidemiology of chronic myeloid leukaemia: an update

Benzene Uptake in Hookah Smokers and Non-smokers Attending Hookah Social Events: Regulatory Implications

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