Risk for metabolic diseases in normal weight individuals with visceral fat accumulation: a cross-sectional study in Japan

Tatsumi, Yukako; Nakao, Yoko M.; Masuda, Izuru; Higashiyama, Aya; Takegami, Misa; Nishimura, Kunihiro; Watanabe, Makoto; Okamura, Tomonori; Miyamoto, Yoshihiro

doi:10.1136/bmjopen-2016-013831

Cited by 48 publications

(50 citation statements)

References 38 publications

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“…Visceral fat, not abdominal subcutaneous fat, was associated with systolic and diastolic blood pressure, glucose and lipid levels in non-obese, non-diabetic and pre-diabetic Chinese adults [21]. The positive dose-response relationships of visceral fat and the prevalence of metabolic syndrome has been reported in non-obese, non-diabetic Japanese subjects [22]. This is possibly true in non-obese diabetic subjects.…”

Section: Visceral or Intra-abdominal Fatmentioning

confidence: 83%

Dysregulated lipid storage and its relationship with insulin resistance and cardiovascular risk factors in non-obese Asian patients with type 2 diabetes

Rattarasarn

2018

Adipocyte

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The prevalence of non-obese type 2 diabetes in Asians is up to 50%. This review aims to summarize the role of regional fat in the development of insulin resistance and cardiovascular risk in non-obese Asian type 2 diabetes as well as the role of intra-pancreatic fat and β-cell dysfunction. The body fat content of non-obese Asian type 2 diabetic patients is not different from that of non-diabetic subjects but the proportion of intra-abdominal and intra-hepatic fat are greater. Visceral fat contributes to insulin resistance and cardiovascular risk in non-obese Asian type 2 diabetes. Intra-hepatic fat and the hypertrophic abdominal subcutaneous adipocytes are associated with insulin resistance and cardiovascular risk in non-obese, non-diabetic Asian subjects. It may be true in non-obese Asian type 2 diabetic patients. The role of intra-myocellular lipid and insulin resistance is uncertain. Intra-pancreatic fat may not be involved in β-cell dysfunction in non-obese Asian type 2 diabetes.

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Section: Visceral or Intra-abdominal Fatmentioning

confidence: 83%

Dysregulated lipid storage and its relationship with insulin resistance and cardiovascular risk factors in non-obese Asian patients with type 2 diabetes

Rattarasarn

2018

Adipocyte

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“…In Korea, the prevalence of MS is increasing owing to the westernization of eating patterns and physical inactivity [ 4 , 5 ]. To date, the most convincing pathogenesis of MS is the result of increased insulin resistance due to excessive visceral fat accumulation [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Cutoff Pericardial Adipose Tissue Volume Associated with Metabolic Syndrome

Kim

Choi

et al. 2018

Korean J Fam Med

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BackgroundMetabolic syndrome (MS) is a well-known risk factor of cardiovascular diseases that is focused on central obesity. Recent studies have reported the association between pericardial adipose tissue (PAT) volume and MS. However, no studies have demonstrated the cutoff PAT volume that represents the best association with MS.MethodsThe data of 374 subjects were analyzed cross-sectionally to compare PAT, measured on coronary multidetector computed tomography, and various metabolic parameters according to MS. After PAT volumes were divided into tertiles, various metabolic parameters were compared among tertiles; furthermore, the odds ratio for developing MS was calculated. Finally, we demonstrated the cutoff PAT volume that represented the best association with MS by using the receiver-operating characteristic curve.ResultsWe found that 27.5% of the subjects had MS, and the mean PAT volume was 123.9 cm3. PAT showed a significant positive correlation with body mass index, waist circumference, and levels of glucose, triglyceride, high-sensitivity C-reactive protein, uric acid, and homocysteine, but a negative correlation with high-density lipoprotein cholesterol. Furthermore, after dividing into tertiles, PAT volume was also significantly associated with various metabolic parameters. The odds ratio for having MS was 4.19 (95% confidence interval, 2.27–7.74) in the top tertile of PAT volumes after adjusting for age, sex, and smoking. The cutoff PAT volume that represented the best association with MS was 142.2 cm3.ConclusionPAT was significantly associated with MS and various metabolic parameters. The cutoff PAT volume of 142.2 cm3 showed the best association with MS.

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“…Despite the rapid increase in incident diabetes and prediabetes, there has not been enough attention paid to prevention. Physical inactivity has been one of the major risk factors for the development of type 2 diabetes mellitus. Exercise training is a recognized strategy that is central to the prevention, treatment and management of diabetes and prediabetes.…”

Section: Introductionmentioning

confidence: 99%

Inverse association between physical activity and blood glucose is independent of sex, menopause status and first‐degree family history of diabetes

Wang

Yang

et al. 2019

J of Diabetes Invest

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Aims/IntroductionExercise training is a recognized strategy central to the prevention, treatment, and management of diabetes and prediabetes. The aim of the present study was to investigate the association between physical activity and blood glucose, as well as the influence of sex, menopause status and family history of diabetes.Materials and MethodsParticipants with normal weight were selected from Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal Study, and divided into inactive (moderate‐to‐vigorous‐intensity physical activity [MVPA] <30 min/week), low‐degree (MVPA ≥30 and ≤420 min/week) and high‐degree (MVPA >420 min/week) activity groups.ResultsA total of 2,601 individuals with an average age of 57.85 ± 8.39 years were enrolled. Multivariate anova uncovered that after adjustment for sex and menopause status, and family history of diabetes, respectively, fasting plasma glucose, 2‐h plasma glucose and glycated hemoglobin A1c decreased through inactive, low‐degree and high‐degree activity groups (all P for trend <0.05). The association of blood glucose indexes with physical activity was independent of this association with sex and menopause status, and first‐degree family history of diabetes, respectively. Multivariate linear regression analyses showed that MVPA was an independent factor associated negatively with fasting plasma glucose, 2‐h plasma glucose and glycated hemoglobin A1c, respectively (all P < 0.01).ConclusionsA higher degree of physical activity was associated with lower blood glucose regardless of sex, menopause status and first‐degree family history of diabetes. MVPA is a negative factor associated with blood glucose independently. Physical activity of adequate duration and intensity is strongly recommended to individuals with susceptibility to diabetes as a result of sex and family history, but without overweight/obesity.

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Risk for metabolic diseases in normal weight individuals with visceral fat accumulation: a cross-sectional study in Japan

Cited by 48 publications

References 38 publications

Dysregulated lipid storage and its relationship with insulin resistance and cardiovascular risk factors in non-obese Asian patients with type 2 diabetes

Dysregulated lipid storage and its relationship with insulin resistance and cardiovascular risk factors in non-obese Asian patients with type 2 diabetes

The Cutoff Pericardial Adipose Tissue Volume Associated with Metabolic Syndrome

Inverse association between physical activity and blood glucose is independent of sex, menopause status and first‐degree family history of diabetes

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