Inverse association between physical activity and blood glucose is independent of sex, menopause status and first‐degree family history of diabetes

Abstract

Aims/IntroductionExercise training is a recognized strategy central to the prevention, treatment, and management of diabetes and prediabetes. The aim of the present study was to investigate the association between physical activity and blood glucose, as well as the influence of sex, menopause status and family history of diabetes.Materials and MethodsParticipants with normal weight were selected from Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal Study, and divided into inactive (moderate‐to‐vigorous‐intensity physical activity [MVPA] <30 min/week), low‐degree (MVPA ≥30 and ≤420 min/week) and high‐degree (MVPA >420 min/week) activity groups.ResultsA total of 2,601 individuals with an average age of 57.85 ± 8.39 years were enrolled. Multivariate anova uncovered that after adjustment for sex and menopause status, and family history of diabetes, respectively, fasting plasma glucose, 2‐h plasma glucose and glycated hemoglobin A1c decreased through inactive, low‐degree and high‐degree activity groups (all P for trend <0.05). The association of blood glucose indexes with physical activity was independent of this association with sex and menopause status, and first‐degree family history of diabetes, respectively. Multivariate linear regression analyses showed that MVPA was an independent factor associated negatively with fasting plasma glucose, 2‐h plasma glucose and glycated hemoglobin A1c, respectively (all P < 0.01).ConclusionsA higher degree of physical activity was associated with lower blood glucose regardless of sex, menopause status and first‐degree family history of diabetes. MVPA is a negative factor associated with blood glucose independently. Physical activity of adequate duration and intensity is strongly recommended to individuals with susceptibility to diabetes as a result of sex and family history, but without overweight/obesity.

A practical approach to the clinical challenges in initiation of basal insulin therapy in people with type 2 diabetes

“…A diabetes‐specific instrument, where patients look for patterns in their perceived stress levels and their blood glucose levels, may help patients to understand the relationship between stress and blood glucose levels 53 . A higher degree of physical activity can lower FPG, 54 and therefore, a change in exercise pattern could cause variability in FPG. Specific exercise recommendations are discussed in a later section.…”

The Impact of Glucose on Corticospinal and Intracortical Excitability

“…Participants passed a screening for TMS contraindications [18] and were identified as right-handed using a modified handedness questionnaire [19]. Inactive individuals were excluded using the International Physical Activity Questionnaire (IPAQ, <600 MET-minutes/week) to reduce the risk of influence from prediabetic impairment of glucose metabolism, which is inversely correlated with physical activity level [20]. This study was approved by the Hamilton Integrated Research Ethics Board (HiREB) and conformed to the declaration of Helsinki.…”

Factors associated with the CVD risk factors and body fat pattern of postmenopausal Hindu caste and Lodha tribal populations living in India: An exploratory study

“…Our study found physical activity to have an inverse association with the blood glucose level; this could be a reason behind the lower incidence of diabetes among the tribal participants. A recent study conducted among Chinese women reveals that a higher degree of physical activity was associated with lower blood glucose level regardless of sex, menopausal status and first-degree family history of diabetes [ 65 ]. Physical inactivity and obesity are critical and modifiable risk factors of diabetes; this could be a justification of the increased blood glucose level among the urban Hindu caste participants as most of them were found to be engaged in sedentary activities.…”