Risk factors, prevalence, and course of severe fatigue after breast cancer treatment: a meta-analysis involving 12 327 breast cancer survivors

Abrahams, H.J.G.; Gielissen, Marieke; Schmits, Iris C.; Verhagen, C.A.H.H.V.M.; Rovers, Maroeska M.; Knoop, Hans

doi:10.1093/annonc/mdw099

Cited by 290 publications

(315 citation statements)

References 49 publications

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“…The role of social support in renal fatigue was greatly accentuated throughout the narratives here, in contrast to some quantitative studies which reported negative findings on the role of social support in fatigue (Picariello et al ., 2017). Therefore, loneliness and isolation may only further exacerbate fatigue (Abrahams et al ., 2016; Wu & McSweeney, 2007). …”

Section: Discussionmentioning

confidence: 99%

‘It's when you're not doing too much you feel tired’: A qualitative exploration of fatigue in end‐stage kidney disease

Picariello

Moss‐Morris

Macdougall

et al. 2017

British J Health Psychol

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BackgroundFatigue is commonly experienced in end‐stage kidney disease (ESKD) patients. In order to develop patient‐centred psychosocial interventions to help patients manage fatigue symptoms, a more in‐depth understanding regarding the experience of fatigue is needed.ObjectiveThe objective of this study was to explore renal patients’ experiences of fatigue, across renal replacement therapy (RRT) modalities.MethodsTwenty‐five in‐depth semi‐structured interviews were conducted. Interviews were audio‐taped, transcribed, and analysed using inductive thematic analysis.ResultsMain themes included the strong role of the illness and treatment in the aetiology of fatigue. Two contrasting streams of illness–fatigue interpretations emerged: catastrophizing versus normalizing. Participants emphasized the importance of having a sense of purpose in facilitating active management of fatigue. Many participants described the consequences of fatigue on their functioning. Low mood, frustration, and anger were common emotional consequences of fatigue. Three dominant fatigue management strategies emerged: one related to accommodation of activities around fatigue, another on increasing activities to counteract fatigue, and the third one revolved around self‐compassion. Social support emerged as an important aspect of the fatigue experience, serving as a source of motivation, yet participants were wary of becoming a burden to others.ConclusionFindings identify casual attributions, behavioural and emotional reactions, management strategies, and facilitators of active management of fatigue in ESKD. Untying fatigue from the illness and treatment may help patients to develop alternative less catastrophic perceptions of fatigue, increase their perception of control over fatigue, and facilitate active fatigue management. Statement of contribution What is already known on this subject? Fatigue is persistent and debilitating in end‐stage kidney disease (ESKD), with no consistent treatment model.Promising evidence is available for psychological fatigue interventions in other chronic conditions.There is a gap in studies looking at the fatigue experiences of patients with ESKD across renal replacement therapies. What does this study add? Fatigue is not inherently negative, but shaped by patients’ beliefs and behaviours.Findings provide novel insights, for example, on the important role social support seems to play in fatigue.An in‐depth understanding of fatigue may help to inform a future patient‐centred intervention in ESKD.

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Section: Discussionmentioning

confidence: 99%

‘It's when you're not doing too much you feel tired’: A qualitative exploration of fatigue in end‐stage kidney disease

Picariello

Moss‐Morris

Macdougall

et al. 2017

British J Health Psychol

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“…Indeed, comorbid psychological symptoms are highly prevalent among adults with physical chronic disease (Abrahams et al, 2016;Cruess et al, 2003;Matte et al, 2016;McCabe, 2010). Among the most prevalent comorbid psychological symptoms, four major psychological factors, namely depression, anxiety, fatigue, and pain, are related with a more rapid disease progression.…”

Section: Introductionmentioning

confidence: 99%

Cognitive behavior therapy combined with exercise for adults with chronic diseases: Systematic review and meta-analysis.

Bernard¹,

Romain²,

Caudroit³

et al. 2018

Health Psychology

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“…In breast cancer patients, psychosocial support by a partner significantly decreased CRF, whereas advanced disease stage and more complex multimodal therapy enhances CRF [2]. This correlates with findings in Hodgkin's lymphoma, where higher tumor burdens predict more severe fatigue levels [3].…”

Section: Fatiguementioning

confidence: 73%

“…Depending on disease and risk factors, about a third of patients develop severe CRF [2,3], which lasts for about 6-12 months. However, fatigue levels are still higher than in the normal population even 5-16 years after sufficient therapy [4].…”

Section: Fatiguementioning

confidence: 99%

Rehabilitation of Cancer Survivors with Long-Term Toxicities

Schmielau¹,

Rick

Reuß‐Borst³

et al. 2017

Oncol Res Treat

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The prognosis of cancer patients is constantly improving, which increases the importance of securing long-term quality of life. While therapy of treatment-related disability mostly succeeds a cancer-specific treatment, physicians' awareness of simultaneous supportive therapy is rising. Early interventions such as physical exercise during chemotherapy are effective in reducing conditions such as fatigue. Specific sensorimotor training is able to improve or even prevent impairment of balance caused by neurotoxic agents. Although targeted therapies reduce the risk of side effects, combinations with established drugs have to be monitored with regard to cardiotoxicity, which is already a concern in children's cancer therapy and is now also focused on in long-term adult survivors. Improvement in diagnosis und surgical procedures have reduced impairments such as lymphedema. Furthermore, management and quality of life of breast cancer patients benefit from evidence showing that physical exercise and resistance training do not increase the risk of developing lymphedema.

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Risk factors, prevalence, and course of severe fatigue after breast cancer treatment: a meta-analysis involving 12 327 breast cancer survivors

Cited by 290 publications

References 49 publications

‘It's when you're not doing too much you feel tired’: A qualitative exploration of fatigue in end‐stage kidney disease

‘It's when you're not doing too much you feel tired’: A qualitative exploration of fatigue in end‐stage kidney disease

Cognitive behavior therapy combined with exercise for adults with chronic diseases: Systematic review and meta-analysis.

Rehabilitation of Cancer Survivors with Long-Term Toxicities

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